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    AGBE 1,4-Alpha-Glucan Branching Enzyme [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 326264, updated on 9-Dec-2024

    Summary

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    Official Symbol
    AGBEprovided by FlyBase
    Official Full Name
    1,4-Alpha-Glucan Branching Enzymeprovided by FlyBase
    Primary source
    FLYBASE:FBgn0053138
    Locus tag
    Dmel_CG33138
    See related
    AllianceGenome:FB:FBgn0053138
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG33138; CG4023; Dmel\CG33138
    Summary
    Predicted to enable 1,4-alpha-glucan branching enzyme activity. Involved in determination of adult lifespan and intracellular iron ion homeostasis. Predicted to be active in cytosol. Is expressed in several structures, including adult head; adult heart; germline cell; larval muscle system; and larval somatic muscle cell. Used to study porphyria. Human ortholog(s) of this gene implicated in glycogen storage disease IV and pulmonary tuberculosis. Orthologous to human GBE1 (1,4-alpha-glucan branching enzyme 1). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
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    Genomic context

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    See AGBE in Genome Data Viewer
    Location:
    49F4-49F4; 2-68 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (13171401..13174796)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (9058906..9062301)

    Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene Glial Lazarillo Neighboring gene antisense RNA:CR45142 Neighboring gene Serine palmitoyltransferase subunit I Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene Lysine demethylase 4B Neighboring gene sequoia

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Improved statistical methods enable greater sensitivity in rhythm detection for genome-wide data. Hutchison AL, et al. PLoS Comput Biol, 2015 Mar. PMID 25793520, Free PMC Article
    2. The role of glycogen in development and adult fitness in Drosophila. Yamada T, et al. Development, 2019 Apr 15. PMID 30918052
    3. Cellular iron sensing and regulation: Nuclear IRP1 extends a classic paradigm. Hernández-Gallardo AK, et al. Biochim Biophys Acta Mol Cell Res, 2020 Jul. PMID 32199885
    4. Fat body glycogen serves as a metabolic safeguard for the maintenance of sugar levels in Drosophila. Yamada T, et al. Development, 2018 Mar 14. PMID 29467247
    5. Glycogen branching enzyme controls cellular iron homeostasis via Iron Regulatory Protein 1 and mitoNEET. Huynh N, et al. Nat Commun, 2019 Nov 29. PMID 31784520, Free PMC Article

    See all (49) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables 1,4-alpha-glucan branching enzyme activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables 1,4-alpha-glucan branching enzyme activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables 1,4-alpha-glucan branching enzyme activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables 1,4-alpha-glucan branching enzyme activity NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    enables catalytic activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables cation binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables hydrolase activity, hydrolyzing O-glycosyl compounds IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in carbohydrate metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in determination of adult lifespan IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in glycogen biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in glycogen biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in glycogen biosynthetic process NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in intracellular iron ion homeostasis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in cytosol ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    1,4-Alpha-Glucan branching enzyme
    Names
    AGBE-PA
    CG33138-PA
    NP_788342.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033778.4 Reference assembly

      Range
      13171401..13174796
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_176162.3 → NP_788342.1  1,4-Alpha-Glucan branching enzyme [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_788342.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A1Z992, U3NIM6
      Related
      FBpp0086845
      Conserved Domains (4) summary
      cd02854
      Location:62 → 161
      E_set_GBE_euk_N; N-terminal Early set domain associated with the catalytic domain of eukaryotic glycogen branching enzyme (also called 1,4 alpha glucan branching enzyme)
      cd11321
      Location:167 → 570
      AmyAc_bac_euk_BE; Alpha amylase catalytic domain found in bacterial and eukaryotic branching enzymes
      COG0296
      Location:52 → 682
      GlgB; 1,4-alpha-glucan branching enzyme [Carbohydrate transport and metabolism]
      pfam02806
      Location:588 → 683
      Alpha-amylase_C; Alpha amylase, C-terminal all-beta domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A1Z992 A1Z992
    Q8T0H4 Q8T0H4

    Gene LinkOut

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