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    Ho Heme oxygenase [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 41407, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Hoprovided by FlyBase
    Official Full Name
    Heme oxygenaseprovided by FlyBase
    Primary source
    FLYBASE:FBgn0037933
    Locus tag
    Dmel_CG14716
    See related
    AllianceGenome:FB:FBgn0037933
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG14716; CT34507; dHO; Dmel\CG14716; DmHO; ho; HO; Ho-1; HO-1; HOX
    Summary
    Enables heme oxygenase (decyclizing) activity. Involved in heme metabolic process. Located in endomembrane system. Is expressed in adult head and organism. Human ortholog(s) of this gene implicated in several diseases, including artery disease (multiple); cerebrovascular disease (multiple); factor VIII deficiency; lung disease (multiple); and sickle cell anemia. Orthologous to several human genes including HMOX1 (heme oxygenase 1). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    Location:
    86E15-86E15; 3-51 cM
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (11679743..11680976)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (7505465..7506698)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene TBP-associated factor 12 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Daily Regulation of Phototransduction, Circadian Clock, DNA Repair, and Immune Gene Expression by Heme Oxygenase in the Retina of Drosophila. Damulewicz M, et al. Genes (Basel), 2018 Dec 21. PMID 30583479, Free PMC Article
    2. Haeme oxygenase protects against UV light DNA damages in the retina in clock-dependent manner. Damulewicz M, et al. Sci Rep, 2017 Jul 12. PMID 28701782, Free PMC Article
    3. Lignin-carbohydrate complexes suppress SCA3 neurodegeneration via upregulating proteasomal activities. Chen ZS, et al. Int J Biol Macromol, 2022 Oct 1. PMID 35872311
    4. Interactions Between the Circadian Clock and Heme Oxygenase in the Retina of Drosophila melanogaster. Damulewicz M, et al. Mol Neurobiol, 2017 Sep. PMID 27520276, Free PMC Article
    5. Reciprocal regulation of carbon monoxide metabolism and the circadian clock. Klemz R, et al. Nat Struct Mol Biol, 2017 Jan. PMID 27892932

    See all (60) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. HO can be tightly regulated at developmental stages and the relevant expression is necessary for the normal development of tissues in Drosophila.
      Title: Relevant expression of Drosophila heme oxygenase is necessary for the normal development of insect tissues.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables heme oxygenase (decyclizing) activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables heme oxygenase (decyclizing) activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in heme metabolic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in heme oxidation IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in endomembrane system HDA PubMed 

    General protein information

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    Preferred Names
    heme oxygenase
    Names
    CG14716-PA
    Ho-PA
    haem oxygenase
    NP_524321.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      11679743..11680976
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_079597.3 → NP_524321.1  heme oxygenase [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_524321.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VGJ9
      Related
      FBpp0081900
      Conserved Domains (1) summary
      pfam01126
      Location:25 → 265
      Heme_oxygenase; Heme oxygenase
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9VGJ9 Q9VGJ9

    Gene LinkOut

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