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    dUTPase Deoxyuridine triphosphatase [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 34529, updated on 9-Dec-2024

    Summary

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    Official Symbol
    dUTPaseprovided by FlyBase
    Official Full Name
    Deoxyuridine triphosphataseprovided by FlyBase
    Primary source
    FLYBASE:FBgn0250837
    Locus tag
    Dmel_CG4584
    See related
    AllianceGenome:FB:FBgn0250837
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    anon-SAGE:Wang-077; BcDNA:LD08534; CG4584; Dmel\CG4584; LD08534; UTPase
    Summary
    Enables dUTP diphosphatase activity. Involved in dUTP metabolic process. Located in cytoplasm and nucleus. Is expressed in several structures, including CNS glial cell; amnioserosa; central brain primordium; embryonic/larval midgut primordium; and ventral nerve cord. Orthologous to human DUT (deoxyuridine triphosphatase). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See dUTPase in Genome Data Viewer
    Location:
    32C1-32C1; 2-44 cM
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (11011312..11012135)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (11011312..11012135)

    Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene Ribosomal protein L9 Neighboring gene Nucleoporin 154kD Neighboring gene antisense RNA:CR45778 Neighboring gene Arginine methyltransferase 8 Neighboring gene SAM-motif ubiquitously expressed punctatedly localized protein Neighboring gene Accessory gland protein 32CD Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Control of Drosophila deoxyuridine triphosphatase. Existence of a developmentally expressed protein inhibitor. Nation MD, et al. Biochem J, 1989 Apr 15. PMID 2541693, Free PMC Article
    2. Drosophila deoxyuridine triphosphatase. Purification and characterization. Giroir LE, et al. J Biol Chem, 1987 Jan 5. PMID 3025197
    3. dUTPase expression correlates with cell division potential in Drosophila melanogaster. Horváth A, et al. FEBS J, 2015 May. PMID 25735890
    4. The Stl repressor from Staphylococcus aureus is an efficient inhibitor of the eukaryotic fruitfly dUTPase. Benedek A, et al. FEBS Open Bio, 2018 Feb. PMID 29435406, Free PMC Article
    5. Multidimensional NMR identifies the conformational shift essential for catalytic competence in the 60-kDa Drosophila melanogaster dUTPase trimer. Dubrovay Z, et al. J Biol Chem, 2004 Apr 23. PMID 14724273

    See all (63) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. revealed the importance of the PAA(10-12) tripeptide and the ID(17-18) dipeptide, as well as the role of the PAAK(10-13) segment in nuclear localization of dUTPase.
      Title: Drosophila proteins involved in metabolism of uracil-DNA possess different types of nuclear localization signals.
    2. dUTPase localization character showed strict timing to the nuclear cleavage phases and explained how its isoforms can be present within the nuclear microenvironment, although at different stages of cell cycle.
      Title: Nuclear localization signal-dependent and -independent movements of Drosophila melanogaster dUTPase isoforms during nuclear cleavage.
    3. kinetic characterization, folding, and crystallographic studies of dUTPase
      Title: Altered active site flexibility and a structural metal-binding site in eukaryotic dUTPase: kinetic characterization, folding, and crystallographic studies of the homotrimeric Drosophila enzyme.
    4. there is a conformational shift essential for catalytic competence in the 60-kDa Drosophila melanogaster dUTPase trimer
      Title: Multidimensional NMR identifies the conformational shift essential for catalytic competence in the 60-kDa Drosophila melanogaster dUTPase trimer.
    5. dUTPase is developmentally regulated in Drosophila melanogaster
      Title: Developmental regulation of dUTPase in Drosophila melanogaster.
    6. dUTPase, a recently described eukaryotic model, has a similar affinity of binding towards alpha,beta-imino-dUTP as compared to the prokaryotic E. coli enzyme
      Title: Mechanistic studies of dUTPases.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables dUTP diphosphatase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables dUTP diphosphatase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables dUTP diphosphatase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables magnesium ion binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables magnesium ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in dUMP biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in dUMP biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in dUTP catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in dUTP catabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in dUTP metabolic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus HDA PubMed 
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in plasma membrane HDA PubMed 

    General protein information

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    Preferred Names
    deoxyuridine triphosphatase
    Names
    CG4584-PA
    CG4584-PB
    CG4584-PC
    CG4584-PD
    anon-SAGE:Wang-077
    dUTPase-PA
    dUTPase-PB
    dUTPase-PC
    dUTPase-PD
    NP_001260370.1
    NP_001260371.1
    NP_609479.1
    NP_723647.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033779.5 Reference assembly

      Range
      11011312..11012135
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_135635.4 → NP_609479.1  deoxyuridine triphosphatase, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_609479.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9V3I1
      Related
      FBpp0079746
      Conserved Domains (1) summary
      cl00493
      Location:10 → 159
      trimeric_dUTPase; Trimeric dUTP diphosphatases

    2. NM_001273441.2 → NP_001260370.1  deoxyuridine triphosphatase, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001260370.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8IPB1
      Conserved Domains (1) summary
      cl00493
      Location:8 → 145
      trimeric_dUTPase; Trimeric dUTP diphosphatases

    3. NM_001273442.2 → NP_001260371.1  deoxyuridine triphosphatase, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001260371.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8IPB1
      Conserved Domains (1) summary
      cl00493
      Location:8 → 145
      trimeric_dUTPase; Trimeric dUTP diphosphatases

    4. NM_164956.3 → NP_723647.1  deoxyuridine triphosphatase, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_723647.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8IPB1
      Related
      FBpp0079745
      Conserved Domains (1) summary
      cl00493
      Location:8 → 145
      trimeric_dUTPase; Trimeric dUTP diphosphatases
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8IPB1 Q8IPB1
    Q9V3I1 Q9V3I1

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