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    RhoGAP93B Rho GTPase activating protein at 93B [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 42496, updated on 9-Dec-2024

    Summary

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    Official Symbol
    RhoGAP93Bprovided by FlyBase
    Official Full Name
    Rho GTPase activating protein at 93Bprovided by FlyBase
    Primary source
    FLYBASE:FBgn0038853
    Locus tag
    Dmel_CG3421
    See related
    AllianceGenome:FB:FBgn0038853
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG3421; CrGAP; Dmel\CG3421; RhoGAP; rhoGAP93B; vilse; Vilse
    Summary
    Enables GTPase activator activity. Involved in axon midline choice point recognition. Located in cytoplasm. Is expressed in adult fat body; adult head; and leg. Orthologous to human ARHGAP39 (Rho GTPase activating protein 39). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See RhoGAP93B in Genome Data Viewer
    Location:
    93B10-93B11; 3-70 cM
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (21083043..21097827, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (16908765..16923549, complement)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene doublesex-Mab related 93B Neighboring gene Hematopoietically expressed homeobox Neighboring gene long non-coding RNA:CR44178 Neighboring gene uncharacterized protein Neighboring gene antisense RNA:CR46045 Neighboring gene TBC1 domain family member 22

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Son of sevenless directly links the Robo receptor to rac activation to control axon repulsion at the midline. Yang L, et al. Neuron, 2006 Nov 22. PMID 17114045
    2. Vilse, a conserved Rac/Cdc42 GAP mediating Robo repulsion in tracheal cells and axons. Lundström A, et al. Genes Dev, 2004 Sep 1. PMID 15342493, Free PMC Article
    3. Vascular control of the Drosophila haematopoietic microenvironment by Slit/Robo signalling. Morin-Poulard I, et al. Nat Commun, 2016 May 19. PMID 27193394, Free PMC Article
    4. Glial-secreted Netrins regulate Robo1/Rac1-Cdc42 signaling threshold levels during Drosophila asymmetric neural stem/progenitor cell division. de Torres-Jurado A, et al. Curr Biol, 2022 May 23. PMID 35472309
    5. Inference of RhoGAP/GTPase regulation using single-cell morphological data from a combinatorial RNAi screen. Nir O, et al. Genome Res, 2010 Mar. PMID 20144944, Free PMC Article

    See all (48) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables GTPase activator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables GTPase activator activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables GTPase activator activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in axon guidance IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in axon guidance IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in axon midline choice point recognition IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Rho GTPase activating protein at 93B
    Names
    CG3421-PA
    RhoGAP93B-PA

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      21083043..21097827 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_142682.2 → NP_650939.2  Rho GTPase activating protein at 93B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_650939.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q86P77, Q9VDE9
      Related
      FBpp0083438
      Conserved Domains (3) summary
      cd04389
      Location:1133 → 1320
      RhoGAP_KIAA1688; RhoGAP_KIAA1688: GTPase-activator protein (GAP) domain for Rho-like GTPases found in KIAA1688-like proteins; KIAA1688 is a protein of unknown function that contains a RhoGAP domain and a myosin tail homology 4 (MyTH4) domain. Small GTPases cluster into ...
      pfam00397
      Location:50 → 75
      WW; WW domain
      cl02480
      Location:956 → 1122
      MyTH4; MyTH4 domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q7YU00 Q7YU00
    Q86P77 Q86P77
    Q9VDE9 Q9VDE9

    Gene LinkOut

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