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    Hip14 Huntingtin-interacting protein 14 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 39747, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Hip14provided by FlyBase
    Official Full Name
    Huntingtin-interacting protein 14provided by FlyBase
    Primary source
    FLYBASE:FBgn0259824
    Locus tag
    Dmel_CG6017
    See related
    AllianceGenome:FB:FBgn0259824
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    3L1; CG 6017; CG6017; dHip14; dHIP14; Dmel\CG6017; hip14; HIP14; l(3)72Ad
    Summary
    Predicted to enable protein-cysteine S-palmitoyltransferase activity. Involved in positive regulation of protein secretion; spermatogenesis; and synaptic vesicle exocytosis. Located in Golgi apparatus and synaptic vesicle. Is expressed in several structures, including adult head; brain; central nervous system; embryonic central brain neurons; and larval muscle cell. Orthologous to several human genes including ZDHHC17 (zinc finger DHHC-type palmitoyltransferase 17). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
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    Genomic context

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    See Hip14 in Genome Data Viewer
    Location:
    72C1-72C1; 3-43 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (15988236..15992464)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (15981336..15985564)

    Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene ADP ribosylation factor-like 1 Neighboring gene long non-coding RNA:CR45446 Neighboring gene DNA polymerase delta subunit 1 Neighboring gene herzog Neighboring gene mitochondrial ribosomal protein S31 Neighboring gene mind bomb 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Presynaptic dysfunction in Huntington's disease. Rozas JL, et al. Biochem Soc Trans, 2010 Apr. PMID 20298208
    2. Cysteine string proteins. Gundersen CB. Prog Neurobiol, 2020 May. PMID 32044380
    3. dHIP14-dependent palmitoylation promotes secretion of the BMP antagonist Sog. Kang KH, et al. Dev Biol, 2010 Oct 1. PMID 20599894, Free PMC Article
    4. Membrane targeting of inhibitory Smads through palmitoylation controls TGF-β/BMP signaling. Li W, et al. Proc Natl Acad Sci U S A, 2017 Dec 12. PMID 29180412, Free PMC Article
    5. The S-palmitoylome and DHHC-PAT interactome of Drosophila melanogaster S2R+ cells indicate a high degree of conservation to mammalian palmitoylomes. Porcellato E, et al. PLoS One, 2022. PMID 35960718, Free PMC Article

    See all (39) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Gain of function screen of PATs reveals an essential role of Hip14 in Drosophila host defense.
      Title: Gain of function screen of PATs reveals an essential role of Hip14 in Drosophila host defense.
    2. Our data indicate that Huntingtin-interacting protein 14 (hip14) controls neurotransmitter release by regulating the trafficking of CSP to synapses.
      Title: Huntingtin-interacting protein 14, a palmitoyl transferase required for exocytosis and targeting of CSP to synaptic vesicles.
    3. Drosophila Huntingtin-interacting protein 14 (HIP14) is an essential maternal effect gene required for photoreceptor synaptic transmission and for proper in vivo expression of the palmitoylated presynaptic proteins SNAP-25 and cysteine string protein.
      Title: Drosophila huntingtin-interacting protein 14 is a presynaptic protein required for photoreceptor synaptic transmission and expression of the palmitoylated proteins synaptosome-associated protein 25 and cysteine string protein.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables palmitoyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein-cysteine S-palmitoyltransferase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in chemical synaptic transmission IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of protein secretion IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in spermatogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in synaptic vesicle exocytosis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in Golgi apparatus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in synapse IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in synaptic vesicle IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    Huntingtin-interacting protein 14
    Names
    CG6017-PA
    CG6017-PB
    CG6017-PC
    Hip14-PA
    Hip14-PB
    Hip14-PC
    ankyrin domain
    htt-interacting protein 14
    lethal (3) 72Ad
    NP_001261910.1
    NP_001261911.1
    NP_648824.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_037436.4 Reference assembly

      Range
      15988236..15992464
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001274982.1 → NP_001261911.1  Huntingtin-interacting protein 14, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001261911.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9VUW9
      Conserved Domains (5) summary
      cd00204
      Location:114 → 233
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      pfam01529
      Location:426 → 559
      zf-DHHC; DHHC palmitoyltransferase
      pfam12796
      Location:52 → 142
      Ank_2; Ankyrin repeats (3 copies)
      pfam13857
      Location:198 → 251
      Ank_5; Ankyrin repeats (many copies)
      sd00045
      Location:77 → 108
      ANK; ANK repeat [structural motif]

    2. NM_140567.3 → NP_648824.1  Huntingtin-interacting protein 14, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_648824.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9VUW9
      Related
      FBpp0075273
      Conserved Domains (5) summary
      cd00204
      Location:114 → 233
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      pfam01529
      Location:426 → 559
      zf-DHHC; DHHC palmitoyltransferase
      pfam12796
      Location:52 → 142
      Ank_2; Ankyrin repeats (3 copies)
      pfam13857
      Location:198 → 251
      Ank_5; Ankyrin repeats (many copies)
      sd00045
      Location:77 → 108
      ANK; ANK repeat [structural motif]

    3. NM_001274981.1 → NP_001261910.1  Huntingtin-interacting protein 14, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001261910.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      M9PFE4
      Conserved Domains (5) summary
      cd00204
      Location:114 → 233
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      pfam01529
      Location:426 → 559
      zf-DHHC; DHHC palmitoyltransferase
      pfam12796
      Location:52 → 142
      Ank_2; Ankyrin repeats (3 copies)
      pfam13857
      Location:198 → 251
      Ank_5; Ankyrin repeats (many copies)
      sd00045
      Location:77 → 108
      ANK; ANK repeat [structural motif]
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    M9PFE4 M9PFE4
    Q9VUW9.1 Q9VUW9

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