Zir Zizimin-related [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: Zirprovided by FlyBase
Official Full Name: Zizimin-relatedprovided by FlyBase
Primary source: FLYBASE:FBgn0031216
Locus tag: Dmel_CG11376
See related: AllianceGenome:FB:FBgn0031216
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: anon-EST:Posey54; CG11376; Dm zir; Dmel\CG11376; FBgn 31216
Summary: Enables guanyl-nucleotide exchange factor activity. Involved in melanotic encapsulation of foreign target; phagocytosis; and regulation of Rho protein signal transduction. Is expressed in adult head; organism; and spermatozoon. Human ortholog(s) of this gene implicated in several diseases, including Adams-Oliver syndrome; developmental and epileptic encephalopathy 23; hyper IgE recurrent infection syndrome 2; immune dysregulation-polyendocrinopathy-enteropathy-X-linked syndrome; and viral infectious disease (multiple). Orthologous to several human genes including DOCK8 (dedicator of cytokinesis 8). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	2L	NT_033779.5 (94739..102086)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	2L	NT_033779.4 (94739..102086)

Chromosome 2L - NT_033779.5 Genomic Context describing neighboring genes

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Zir is necessary to activate the Rho-family GTPases Rac2 and Cdc42 during the Drosophila cellular immune response.
Title: The RhoGEF Zizimin-related acts in the Drosophila cellular immune response via the Rho GTPases Rac2 and Cdc42.

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

Function	Evidence Code	Pubs
enables guanyl-nucleotide exchange factor activity	IBA Inferred from Biological aspect of Ancestor more info
enables guanyl-nucleotide exchange factor activity	IEA Inferred from Electronic Annotation more info
enables guanyl-nucleotide exchange factor activity	IGI Inferred from Genetic Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in encapsulation of foreign target	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in melanotic encapsulation of foreign target	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in phagocytosis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of Rho protein signal transduction	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of Rho protein signal transduction	IGI Inferred from Genetic Interaction more info	PubMed
involved_in small GTPase-mediated signal transduction	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in cellular_component	ND No biological Data available more info

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The following sections contain reference sequences that belong to a specific genome build. Explain