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    DCTN4-p62 Dynactin 4, p62 subunit [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 35709, updated on 9-Dec-2024

    Summary

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    Official Symbol
    DCTN4-p62provided by FlyBase
    Official Full Name
    Dynactin 4, p62 subunitprovided by FlyBase
    Primary source
    FLYBASE:FBgn0033206
    Locus tag
    Dmel_CG12042
    See related
    AllianceGenome:FB:FBgn0033206
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG12042; DCTN4; Dmel\CG12042; p62; P62
    Summary
    Predicted to be part of dynactin complex. Is expressed in adult head and organism. Orthologous to human DCTN4 (dynactin subunit 4). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See DCTN4-p62 in Genome Data Viewer
    Location:
    43E9-43E9; 2-57 cM
    Exon count:
    1
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (7667248..7669029, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (3554753..3556534, complement)

    Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene Retinol dehydrogenase 1 Neighboring gene uncharacterized protein Neighboring gene mitochondrial ribosomal protein L52

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Diamond controls epithelial polarity through the dynactin-dynein complex. Zhao H, et al. Traffic, 2023 Dec. PMID 37642208
    2. Traumatic injury induces stress granule formation and enhances motor dysfunctions in ALS/FTD models. Anderson EN, et al. Hum Mol Genet, 2018 Apr 15. PMID 29432563, Free PMC Article
    3. p62 plays a protective role in the autophagic degradation of polyglutamine protein oligomers in polyglutamine disease model flies. Saitoh Y, et al. J Biol Chem, 2015 Jan 16. PMID 25480790, Free PMC Article
    4. Coordinate control of terminal dendrite patterning and dynamics by the membrane protein Raw. Lee J, et al. Development, 2015 Jan 1. PMID 25480915, Free PMC Article
    5. Evolution of the eukaryotic dynactin complex, the activator of cytoplasmic dynein. Hammesfahr B, et al. BMC Evol Biol, 2012 Jun 22. PMID 22726940, Free PMC Article

    See all (35) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Traumatic brain injury leads to ubiquitinated p62 stress granules in frontotemporal dementia-amyotrophic lateral sclerosis Drosophila model.
      Title: Traumatic injury induces stress granule formation and enhances motor dysfunctions in ALS/FTD models.
    2. p62 plays a protective role against polyQ-induced neurodegeneration, by the autophagic degradation of polyQ protein oligomers in vivo
      Title: p62 plays a protective role in the autophagic degradation of polyglutamine protein oligomers in polyglutamine disease model flies.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Component Evidence Code Pubs
    part_of dynactin complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of dynactin complex IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    dynactin 4, p62 subunit
    Names
    CG12042-PA
    DCTN4-p62-PA
    Dynactin4 p62
    P62 DYNACTIN
    p62 subunit of dynactin

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033778.4 Reference assembly

      Range
      7667248..7669029 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_136467.3 → NP_610311.1  dynactin 4, p62 subunit [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_610311.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q7K130
      Related
      FBpp0088018
      Conserved Domains (1) summary
      pfam05502
      Location:20 → 363
      Dynactin_p62; Dynactin p62 family
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q7K130 Q7K130

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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