MED26 Mediator complex subunit 26 [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: MED26provided by FlyBase
Official Full Name: Mediator complex subunit 26provided by FlyBase
Primary source: FLYBASE:FBgn0039923
Locus tag: Dmel_CG1793
See related: AllianceGenome:FB:FBgn0039923
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: ARC 70; Arc70; CG1793; CG1823; dARC70; Dmel\CG1793; med26; Med26
Summary: Predicted to enable transcription coregulator activity. Involved in positive regulation of gene expression and regulation of transcription by RNA polymerase II. Located in nucleolus; pericentric heterochromatin; and polytene chromosome chromocenter. Part of core mediator complex. Is expressed in germline cell; organism; pole plasm; primordial germ cell; and spermatozoon. Orthologous to human MED26 (mediator complex subunit 26). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	4	NC_004353.4 (778516..788978, complement)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	4	NC_004353.3 (799142..809604, complement)

Chromosome 4 - NC_004353.4 Genomic Context describing neighboring genes

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Characterization of drosophila Med26 shows that it is essential for organismal survival but is dispensable for cellular proliferation and viability.
Title: The metazoan-specific mediator subunit 26 (Med26) is essential for viability and is found at both active genes and pericentric heterochromatin in Drosophila melanogaster.

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

Function	Evidence Code	Pubs
enables transcription coregulator activity	IBA Inferred from Biological aspect of Ancestor more info
enables transcription coregulator activity	ISS Inferred from Sequence or Structural Similarity more info	PubMed

Process	Evidence Code	Pubs
involved_in positive regulation of gene expression	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of gene expression	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of transcription by RNA polymerase II	IEA Inferred from Electronic Annotation more info
involved_in regulation of transcription by RNA polymerase II	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of transcription by RNA polymerase II	ISS Inferred from Sequence or Structural Similarity more info	PubMed

Component	Evidence Code	Pubs
located_in chromatin	IDA Inferred from Direct Assay more info	PubMed
part_of core mediator complex	IBA Inferred from Biological aspect of Ancestor more info
part_of core mediator complex	IPI Inferred from Physical Interaction more info	PubMed
part_of mediator complex	IBA Inferred from Biological aspect of Ancestor more info
part_of mediator complex	IEA Inferred from Electronic Annotation more info
part_of mediator complex	ISS Inferred from Sequence or Structural Similarity more info	PubMed
located_in nucleolus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	IEA Inferred from Electronic Annotation more info
located_in pericentric heterochromatin	IPI Inferred from Physical Interaction more info	PubMed
located_in polytene chromosome chromocenter	IDA Inferred from Direct Assay more info	PubMed

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