Sox102F Sox102F [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: Sox102Fprovided by FlyBase
Official Full Name: Sox102Fprovided by FlyBase
Primary source: FLYBASE:FBgn0039938
Locus tag: Dmel_CG11153
See related: AllianceGenome:FB:FBgn0039938
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: CG11153; Dmel\CG11153; Sox D; Sox102D; SOX102D; SOX102F; SoxD; SOXD
Summary: Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in positive regulation of heart contraction. Predicted to be active in nucleus. Is expressed in T neuron; ganglia; and mushroom body primordium. Used to study Alzheimer's disease and heart disease. Human ortholog(s) of this gene implicated in high grade glioma. Orthologous to human SOX13 (SRY-box transcription factor 13); SOX5 (SRY-box transcription factor 5); and SOX6 (SRY-box transcription factor 6). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Genomic context

Location:: 102E1-102E3; 4-0 cM

Exon count:: 8

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	4	NC_004353.4 (800436..834393, complement)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	4	NC_004353.3 (821062..855019, complement)

Chromosome 4 - NC_004353.4 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

findings suggest that SoxD regulates neurite guidance, without affecting neuronal fate.
Title: The transcription factor SoxD controls neuronal guidance in the Drosophila visual system.
To characterize the neuronal role of SOX5, we silenced the Drosophila ortholog of SOX5, Sox102F, by RNAi in various neuronal subtypes in Drosophila. Silencing of Sox102F led to misorientated and disorganized michrochaetes, neurons with shorter dendritic arborization (DA) and reduced complexity, diminished larval peristaltic contractions, loss of neuromuscular junction bouton structures, impaired olfactory perception
Title: Silencing of the Drosophila ortholog of SOX5 leads to abnormal neuronal development and behavioral impairment.
results show silencing of Sox102F, the Drosophila ortholog of SOX5, resulted in severe cardiac dysfunction and structural defects with disrupted Wnt signaling transduction; this implicates an important functional role for SOX5 in heart and suggests that alterations in SOX5 levels may contribute to the pathogenesis of multiple cardiac diseases or traits
Title: Silencing of the Drosophila ortholog of SOX5 in heart leads to cardiac dysfunction as detected by optical coherence tomography.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

NCBI Orthologs

Orthologs from OrthoDB

mobile_element

Loc: c809377-809217 mobile_element_type = transposon:INE-1{}2081
Loc: c811340-811032 mobile_element_type = transposon:INE-1{}2082
Loc: c820196-820014 mobile_element_type = transposon:INE-1{}2680
Loc: c820305-820242 mobile_element_type = transposon:INE-1{}2681
Loc: c823177-822711 mobile_element_type = transposon:INE-1{}2682

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IBA Inferred from Biological aspect of Ancestor more info
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in cell fate commitment	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of heart contraction	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: Sox102F

Names: CG11153-PA; CG11153-PB; CG11153-PC; CG11153-PD; Sox102F-PA; Sox102F-PB; Sox102F-PC; Sox102F-PD

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_004353.4 Reference assembly

Range

800436..834393 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001014695.2 → NP_001014695.1 Sox102F, isoform B [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001014695.1

Status: REVIEWED

UniProtKB/TrEMBL

Q59DN5

Conserved Domains (1) summary

cd01388
Location:422 → 493

SOX-TCF_HMG-box; SOX-TCF_HMG-box, class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and ...
NM_166792.2 → NP_726612.1 Sox102F, isoform A [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_726612.1

Status: REVIEWED

UniProtKB/TrEMBL

Q9V480

Related

FBpp0088312

Conserved Domains (1) summary

cd01388
Location:384 → 455

SOX-TCF_HMG-box; SOX-TCF_HMG-box, class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and ...
NM_001272145.1 → NP_001259074.1 Sox102F, isoform D [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001259074.1

Status: REVIEWED

UniProtKB/TrEMBL

Q9V480

Conserved Domains (1) summary

cd01388
Location:384 → 455

SOX-TCF_HMG-box; SOX-TCF_HMG-box, class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and ...
NM_001272144.1 → NP_001259073.1 Sox102F, isoform C [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001259073.1

Status: REVIEWED

UniProtKB/TrEMBL

Q9V480

Conserved Domains (1) summary

cd01388
Location:384 → 455

SOX-TCF_HMG-box; SOX-TCF_HMG-box, class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and ...