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    Atac2 Ada2a-containing complex component 2 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 35113, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Atac2provided by FlyBase
    Official Full Name
    Ada2a-containing complex component 2provided by FlyBase
    Primary source
    FLYBASE:FBgn0032691
    Locus tag
    Dmel_CG10414
    See related
    AllianceGenome:FB:FBgn0032691
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG10414; dAtac2; dATAC2; Dmel\CG10414; KAT14
    Summary
    Enables histone H2A acetyltransferase activity and histone H4 acetyltransferase activity. Involved in chromatin remodeling and intestinal stem cell homeostasis. Part of ATAC complex. Is expressed in several structures, including anterior endoderm; embryonic/larval midgut primordium; mesoderm; and posterior endoderm. Orthologous to human KAT14 (lysine acetyltransferase 14). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Atac2 in Genome Data Viewer
    Location:
    36F7-36F7; 2-53 cM
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (18609576..18612249, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (18609576..18612249, complement)

    Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene Intraflagellar transport 46 Neighboring gene Misexpression suppressor of ras 3 Neighboring gene Cytochrome P450 310a1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Identification of a histone acetyltransferase as a novel regulator of Drosophila intestinal stem cells. Ma Y, et al. FEBS Lett, 2013 May 21. PMID 23535028
    2. Moco biosynthesis and the ATAC acetyltransferase engage translation initiation by inhibiting latent PKR activity. Suganuma T, et al. J Mol Cell Biol, 2016 Feb. PMID 26705305
    3. ATAC is a double histone acetyltransferase complex that stimulates nucleosome sliding. Suganuma T, et al. Nat Struct Mol Biol, 2008 Apr. PMID 18327268
    4. A metazoan ATAC acetyltransferase subunit that regulates mitogen-activated protein kinase signaling is related to an ancient molybdopterin synthase component. Suganuma T, et al. Mol Cell Proteomics, 2012 May. PMID 22345504, Free PMC Article
    5. The ATAC acetyltransferase complex coordinates MAP kinases to regulate JNK target genes. Suganuma T, et al. Cell, 2010 Sep 3. PMID 20813260

    See all (43) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables acyltransferase activity, transferring groups other than amino-acyl groups IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H2A acetyltransferase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables histone H4 acetyltransferase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables histone acetyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in chromatin remodeling IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in intestinal stem cell homeostasis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of ATAC complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of ATAC complex IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    Ada2a-containing complex component 2
    Names
    ATAC complex component 2
    Atac2-PA
    CG10414-PA
    lysine acetyltransferase 14
    NP_609889.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033779.5 Reference assembly

      Range
      18609576..18612249 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_136045.3 → NP_609889.1  Ada2a-containing complex component 2 [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_609889.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VJ73
      Related
      FBpp0080629
      Conserved Domains (3) summary
      smart00249
      Location:14 → 63
      PHD; PHD zinc finger
      TIGR01575
      Location:639 → 753
      rimI; ribosomal-protein-alanine acetyltransferase
      pfam00583
      Location:676 → 744
      Acetyltransf_1; Acetyltransferase (GNAT) family
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9VJ73 Q9VJ73

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