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    pck pickel [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 31101, updated on 9-Dec-2024

    Summary

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    Official Symbol
    pckprovided by FlyBase
    Official Full Name
    pickelprovided by FlyBase
    Primary source
    FLYBASE:FBgn0013720
    Locus tag
    Dmel_CG14779
    See related
    AllianceGenome:FB:FBgn0013720
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG14779; Dmel\CG14779; EG:80H7.2; l(1)G0044; mega; Mega; Pck; PCK
    Summary
    Involved in establishment of glial blood-brain barrier; open tracheal system development; and septate junction assembly. Located in septate junction. Is expressed in organism. [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See pck in Genome Data Viewer
    Location:
    2A4-2A4; 1-0.2 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (1470666..1472325)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (1364699..1366358)

    Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene Rab27

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. TEV protease-mediated cleavage in Drosophila as a tool to analyze protein functions in living organisms. Harder B, et al. Biotechniques, 2008 May. PMID 18476830
    2. The claudin Megatrachea protein complex. Jaspers MH, et al. J Biol Chem, 2012 Oct 26. PMID 22930751, Free PMC Article
    3. Fluorescent fusion protein knockout mediated by anti-GFP nanobody. Caussinus E, et al. Nat Struct Mol Biol, 2011 Dec 11. PMID 22157958
    4. The fatty acyl-CoA reductase Waterproof mediates airway clearance in Drosophila. Jaspers MH, et al. Dev Biol, 2014 Jan 1. PMID 24183938
    5. The Drosophila stubarista phenotype is associated with a dosage effect of the putative ribosome-associated protein D-p40 on spineless. Melnick MB, et al. Genetics, 1993 Oct. PMID 7916731, Free PMC Article

    See all (78) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Process Evidence Code Pubs
    involved_in establishment of glial blood-brain barrier IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in liquid clearance, open tracheal system IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in open tracheal system development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of tube size, open tracheal system IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of tube size, open tracheal system IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in septate junction assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in septate junction assembly IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in membrane ISM
    Inferred from Sequence Model
    more info
    		 PubMed 
    is_active_in septate junction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in septate junction IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in septate junction ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    pickel
    Names
    CG14779-PA
    CG14779-PC
    CG14779-PD
    megatrachea
    pck-PA
    pck-PC
    pck-PD

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_004354.4 Reference assembly

      Range
      1470666..1472325
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_166887.3 → NP_726742.1  pickel, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_726742.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      E4NKM0, O76899
      Related
      FBpp0070245
      Conserved Domains (1) summary
      cl21598
      Location:39 → 211
      PMP22_Claudin; PMP-22/EMP/MP20/Claudin family

    2. NM_001038731.1 → NP_001033820.1  pickel, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001033820.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q2PE37
      Conserved Domains (1) summary
      cl21598
      Location:39 → 92
      PMP22_Claudin; PMP-22/EMP/MP20/Claudin family

    3. NM_130563.4 → NP_569919.2  pickel, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_569919.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      E4NKM0, O76899
      Related
      FBpp0070246
      Conserved Domains (1) summary
      cl21598
      Location:39 → 211
      PMP22_Claudin; PMP-22/EMP/MP20/Claudin family
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O76899 O76899
    Q2PE37 Q2PE37
    Q8T098 Q8T098

    Gene LinkOut

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