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    fl(2)d female lethal d [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 36527, updated on 9-Dec-2024

    Summary

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    Official Symbol
    fl(2)dprovided by FlyBase
    Official Full Name
    female lethal dprovided by FlyBase
    Primary source
    FLYBASE:FBgn0000662
    Locus tag
    Dmel_CG6315
    See related
    AllianceGenome:FB:FBgn0000662
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG6315; Dmel\CG6315; Fl(2)d; Fl(2d); v(2)k16105
    Summary
    Involved in several processes, including RNA processing; compound eye development; and regulation of alternative mRNA splicing, via spliceosome. Located in nucleus. Part of RNA N6-methyladenosine methyltransferase complex. Is expressed in several structures, including adult brain cell body rind; adult head; germarium; imaginal disc; and larval central nervous system. Orthologous to human WTAP (WT1 associated protein). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See fl(2)d in Genome Data Viewer
    Location:
    50C6-50C6; 2-68 cM
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (13819624..13824553, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (9707129..9712058, complement)

    Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene Cuticular protein 50Cb Neighboring gene straightjacket Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Localization of the Drosophila protein FL(2)D in somatic cells and female gonads. Ortega A. Cell Tissue Res, 2005 May. PMID 15778853
    2. The germline: familiar and newly uncovered properties. Wei G, et al. Annu Rev Genet, 1994. PMID 7893129
    3. The Drosophila fl(2)d gene, required for female-specific splicing of Sxl and tra pre-mRNAs, encodes a novel nuclear protein with a HQ-rich domain. Penalva LO, et al. Genetics, 2000 May. PMID 10790389, Free PMC Article
    4. Molecular identification of virilizer, a gene required for the expression of the sex-determining gene Sex-lethal in Drosophila melanogaster. Niessen M, et al. Genetics, 2001 Feb. PMID 11156988, Free PMC Article
    5. The Drosophila melanogaster fl(2)d gene is needed for the female-specific splicing of Sex-lethal RNA. Granadino B, et al. EMBO J, 1990 Aug. PMID 1695150, Free PMC Article

    See all (91) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The Drosophila Wilms Tumor 1-Associating Protein (WTAP) homolog (Fl(2)d) is required for eye development.
      Title: The Drosophila Wilms׳ Tumor 1-Associating Protein (WTAP) homolog is required for eye development.
    2. Sxl and fl(2)d genes function to alter splice-site selection at an early step in spliceosome assembly.
      Title: Functioning of the Drosophila Wilms'-tumor-1-associated protein homolog, Fl(2)d, in Sex-lethal-dependent alternative splicing.
    3. fl(2)d was localized in somatic cells and the ovary.
      Title: Localization of the Drosophila protein FL(2)D in somatic cells and female gonads.
    4. biochemical function of of this protein in alternative pre-mRNA splicing
      Title: Biochemical function of female-lethal (2)D/Wilms' tumor suppressor-1-associated proteins in alternative pre-mRNA splicing.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in RNA splicing, via transesterification reactions IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in compound eye development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in female germ-line sex determination NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in mRNA modification IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in mRNA modification IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in mRNA processing IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in primary sex determination, soma NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in regulation of alternative mRNA splicing, via spliceosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of alternative mRNA splicing, via spliceosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of alternative mRNA splicing, via spliceosome IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of alternative mRNA splicing, via spliceosome IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    involved_in sex determination IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of RNA N6-methyladenosine methyltransferase complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus HDA PubMed 
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleus TAS
    Traceable Author Statement
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    female lethal d
    Names
    CG6315-PA
    CG6315-PB
    CG6315-PC
    CG6315-PD
    Female-lethal (2)d
    female-lethal(2)d
    fl(2)d-PA
    fl(2)d-PB
    fl(2)d-PC
    fl(2)d-PD

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033778.4 Reference assembly

      Range
      13819624..13824553 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_166010.3 → NP_725327.1  female lethal d, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_725327.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0B4K713
      Related
      FBpp0086774
      Conserved Domains (2) summary
      pfam07106
      Location:103 → 194
      TBPIP; Tat binding protein 1(TBP-1)-interacting protein (TBPIP)
      pfam17098
      Location:1 → 181
      Wtap; Pre-mRNA-splicing regulator WTAP

    2. NM_001259376.2 → NP_001246305.1  female lethal d, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001246305.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0B4K713
      Conserved Domains (2) summary
      pfam07106
      Location:103 → 194
      TBPIP; Tat binding protein 1(TBP-1)-interacting protein (TBPIP)
      pfam17098
      Location:1 → 181
      Wtap; Pre-mRNA-splicing regulator WTAP

    3. NM_001259377.2 → NP_001246306.1  female lethal d, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001246306.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0B4K713
      Conserved Domains (2) summary
      pfam07106
      Location:103 → 194
      TBPIP; Tat binding protein 1(TBP-1)-interacting protein (TBPIP)
      pfam17098
      Location:1 → 181
      Wtap; Pre-mRNA-splicing regulator WTAP

    4. NM_079008.4 → NP_523732.2  female lethal d, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_523732.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A1Z9H6, Q7K100, Q7KA73, Q9U974, Q9Y091
      Related
      FBpp0086773
      Conserved Domains (2) summary
      pfam07106
      Location:227 → 318
      TBPIP; Tat binding protein 1(TBP-1)-interacting protein (TBPIP)
      pfam17098
      Location:110 → 305
      Wtap; Pre-mRNA-splicing regulator WTAP
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A0A0B4K713 A0A0B4K713
    Q9Y091.2 Q9Y091

    Gene LinkOut

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