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    Klp3A Kinesin-like protein at 3A [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 31240, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Klp3Aprovided by FlyBase
    Official Full Name
    Kinesin-like protein at 3Aprovided by FlyBase
    Primary source
    FLYBASE:FBgn0011606
    Locus tag
    Dmel_CG8590
    See related
    AllianceGenome:FB:FBgn0011606
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    3A7Kin; BcDNA:LD21815; CG8590; Dmel\CG8590; DmKlp3A; DmKLP3A; EG:BACR25B3.9; fs(1)M4; KIF 4A; KIF4; KIF4A; Klp 3A; KLP-3A; klp3a; klp3A; Klp3a; KLP3A; mei-352
    Summary
    Enables microtubule binding activity. Involved in several processes, including meiosis I cytokinesis; meiotic nuclear division; and spindle organization. Located in several cellular components, including midbody; nucleus; and spindle. Part of microtubule associated complex. Is expressed in several structures, including central brain primordium; ganglia; mesoderm; spermatozoon; and ventral nerve cord primordium. Used to study epilepsy. Human ortholog(s) of this gene implicated in non-syndromic X-linked intellectual disability 100. Orthologous to several human genes including KIF4A (kinesin family member 4A). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Klp3A in Genome Data Viewer
    Location:
    3A6-3A6; 1-1 cM
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (2599158..2604052, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (2493191..2498085, complement)

    Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene will die slowly Neighboring gene egghead Neighboring gene Zeste-white 10 Neighboring gene SET and MYND domain containing, class 3 Neighboring gene eukaryotic translation initiation factor 3 subunit g1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Nuclear positioning during development: Pushing, pulling and flowing. Deshpande O, et al. Semin Cell Dev Biol, 2021 Dec. PMID 34642103
    2. The chromokinesin Klp3a and microtubules facilitate acentric chromosome segregation. Karg T, et al. J Cell Biol, 2017 Jun 5. PMID 28500183, Free PMC Article
    3. The effect of recombination-defective meiotic mutants on fourth-chromosome crossing over in Drosophila melanogaster. Sandler L, et al. Genetics, 1978 Dec. PMID 105965, Free PMC Article
    4. Chromosomes take the lead in spindle assembly. Vernos I, et al. Trends Cell Biol, 1995 Aug. PMID 14732087
    5. Astral microtubule cross-linking safeguards uniform nuclear distribution in the Drosophila syncytium. Deshpande O, et al. J Cell Biol, 2022 Jan 3. PMID 34766978, Free PMC Article

    See all (129) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Successful acentric chromosome segregation requires the chromokinesin Klp3a.
      Title: The chromokinesin Klp3a and microtubules facilitate acentric chromosome segregation.
    2. KLP3A contributes to spindle pole separation during the prometaphase-to-metaphase transition
      Title: The chromokinesin, KLP3A, dives mitotic spindle pole separation during prometaphase and anaphase and facilitates chromatid motility.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables microtubule binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables microtubule binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables microtubule motor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables microtubule motor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables plus-end-directed microtubule motor activity NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in chromosome segregation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in female meiosis chromosome segregation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in male meiotic nuclear division IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in male meiotic nuclear division TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in meiosis I cytokinesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in microtubule-based movement IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in mitotic cell cycle HMP PubMed 
    involved_in mitotic spindle organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in mitotic spindle organization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in reciprocal meiotic recombination IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of mitotic nuclear division IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in single fertilization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in spindle elongation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in spindle elongation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in aster IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of microtubule associated complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of microtubule associated complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in midbody IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in spindle IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in spindle midzone IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    Kinesin-like protein at 3A
    Names
    CG8590-PA
    CG8590-PB
    Kinesin-Like-Protein-at-3A
    Kinesin5
    Klp3A-PA
    Klp3A-PB
    female sterile(1)M4
    meiotic 352
    NP_001284830.1
    NP_525053.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_004354.4 Reference assembly

      Range
      2599158..2604052 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_080314.3 → NP_525053.1  Kinesin-like protein at 3A, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_525053.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9XZ29
      Related
      FBpp0070432
      Conserved Domains (5) summary
      COG1196
      Location:396 → 994
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      COG3352
      Location:522 → 633
      FlaC; Archaellum component FlaC [Cell motility]
      cd01372
      Location:7 → 336
      KISc_KIF4; Kinesin motor domain, KIF4-like subfamily
      pfam00225
      Location:14 → 335
      Kinesin; Kinesin motor domain
      pfam03638
      Location:1075 → 1110
      TCR; Tesmin/TSO1-like CXC domain, cysteine-rich domain

    2. NM_001297901.1 → NP_001284830.1  Kinesin-like protein at 3A, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001284830.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9XZ29
      Conserved Domains (5) summary
      COG1196
      Location:396 → 994
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      COG3352
      Location:522 → 633
      FlaC; Archaellum component FlaC [Cell motility]
      cd01372
      Location:7 → 336
      KISc_KIF4; Kinesin motor domain, KIF4-like subfamily
      pfam00225
      Location:14 → 335
      Kinesin; Kinesin motor domain
      pfam03638
      Location:1075 → 1110
      TCR; Tesmin/TSO1-like CXC domain, cysteine-rich domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9XZ29 Q9XZ29

    Gene LinkOut

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