Cth Cystathionine gamma-lyase [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: Cthprovided by FlyBase
Official Full Name: Cystathionine gamma-lyaseprovided by FlyBase
Primary source: FLYBASE:FBgn0000566
Locus tag: Dmel_CG5345
See related: AllianceGenome:FB:FBgn0000566
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: CG5345; cse; CSE; Dmel\CG5345; Eip40; EIP40; Eip55BD; Eip55E; LD22255
Summary: Predicted to enable cystathionine gamma-lyase activity and pyridoxal phosphate binding activity. Involved in glutathione biosynthetic process. Predicted to be active in cytoplasm. Is expressed in several structures, including embryonic/larval midgut primordium; gut section; larval muscle cell; mesoderm; and visceral mesoderm derivative. Human ortholog(s) of this gene implicated in amino acid metabolic disorder and cystathioninuria. Orthologous to human CTH (cystathionine gamma-lyase). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	2R	NT_033778.4 (18627918..18629395)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	2R	NT_033778.3 (14515423..14516900)

Chromosome 2R - NT_033778.4 Genomic Context describing neighboring genes

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Deletions of the cystathionine-beta-synthase (CBS) and cystathionine-gamma-lyase (CSE) genes, involved in the control of hydrogen sulfide biosynthesis, significantly affect lifespan and fitness components of Drosophila melanogaster.
Title: Deletions of the cystathionine-β-synthase (CBS) and cystathionine-γ-lyase (CSE) genes, involved in the control of hydrogen sulfide biosynthesis, significantly affect lifespan and fitness components of Drosophila melanogaster.

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

Function	Evidence Code	Pubs
enables cystathionine gamma-lyase activity	IBA Inferred from Biological aspect of Ancestor more info
enables cystathionine gamma-lyase activity	ISS Inferred from Sequence or Structural Similarity more info
enables cystathionine gamma-lyase activity	TAS Traceable Author Statement more info	PubMed
enables pyridoxal phosphate binding	IBA Inferred from Biological aspect of Ancestor more info
enables pyridoxal phosphate binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in cysteine biosynthetic process via cystathionine	IBA Inferred from Biological aspect of Ancestor more info
involved_in glutathione biosynthetic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in sulfur amino acid metabolic process	NAS Non-traceable Author Statement more info	PubMed
involved_in transsulfuration	IBA Inferred from Biological aspect of Ancestor more info
involved_in transsulfuration	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info

Names: CG5345-PA; CG5345-PB; Cth-PA; Cth-PB; Ecdysone-induced polypeptide 40kD; Ecdysone-induced protein 40kD; Ecdysone-induced protein 55E; Eip55E; cystathionine-gamma-lyase; ecdysone induced protein 55E

NP_001286578.1

NP_611352.1

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The following sections contain reference sequences that belong to a specific genome build. Explain