U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    Hgsnat Heparan-alpha-glucosaminide N-acetyltransferase [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 31423, updated on 9-Dec-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    Hgsnatprovided by FlyBase
    Official Full Name
    Heparan-alpha-glucosaminide N-acetyltransferaseprovided by FlyBase
    Primary source
    FLYBASE:FBgn0029737
    Locus tag
    Dmel_CG6903
    See related
    AllianceGenome:FB:FBgn0029737
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG6903; Dmel\CG6903
    Summary
    Predicted to enable heparan-alpha-glucosaminide N-acetyltransferase activity. Predicted to be involved in lysosomal transport. Predicted to be located in lysosomal membrane. Is expressed in adult head and organism. Used to study mucopolysaccharidosis type IIIC. Human ortholog(s) of this gene implicated in mucopolysaccharidosis type IIIC and retinitis pigmentosa 73. Orthologous to human HGSNAT (heparan-alpha-glucosaminide N-acetyltransferase). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See Hgsnat in Genome Data Viewer
    Location:
    4D6-4D6; 1-9 cM
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (4918730..4921648)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (4812763..4815681)

    Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene hairpin RNA:CR46342 Neighboring gene uncharacterized protein Neighboring gene Protein tyrosine phosphatase 4E

    Genomic regions, transcripts, and products

    Go to the top of the page Help

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. Drosophila melanogaster models of MPS IIIC (Hgsnat-deficiency) highlight the role of glia in disease presentation. Hewson L, et al. J Inherit Metab Dis, 2024 Mar. PMID 38238109
    2. An endogenous small interfering RNA pathway in Drosophila. Czech B, et al. Nature, 2008 Jun 5. PMID 18463631, Free PMC Article
    3. Unanchored ubiquitin chains do not lead to marked alterations in gene expression in Drosophila melanogaster. Blount JR, et al. Biol Open, 2019 May 30. PMID 31097444, Free PMC Article
    4. Loss of the endoplasmic reticulum protein Tmem208 affects cell polarity, development, and viability. Dutta D, et al. Proc Natl Acad Sci U S A, 2024 Feb 27. PMID 38381787, Free PMC Article
    5. Drosophila melanogaster: A Valuable Genetic Model Organism to Elucidate the Biology of Retinitis Pigmentosa. Lehmann M, et al. Methods Mol Biol, 2019. PMID 30324448

    See all (26) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

    Go to the top of the page Help

    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables heparan-alpha-glucosaminide N-acetyltransferase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in heparan sulfate proteoglycan catabolic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in lysosomal transport ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    located_in lysosomal membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

    Go to the top of the page Help
    Preferred Names
    Heparan-alpha-glucosaminide N-acetyltransferase
    Names
    CG6903-PA
    CG6903-PB
    Hgsnat-PA
    Hgsnat-PB
    NP_001284872.1
    NP_572198.1

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_004354.4 Reference assembly

      Range
      4918730..4921648
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_131970.1 → NP_572198.1  Heparan-alpha-glucosaminide N-acetyltransferase, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_572198.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9W4F7
      Related
      FBpp0070691, FBtr0070723
      Conserved Domains (1) summary
      cl21495
      Location:185 → 542
      DUF418; Protein of unknown function (DUF418)

    2. NM_001297943.1 → NP_001284872.1  Heparan-alpha-glucosaminide N-acetyltransferase, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001284872.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9W4F7
      Conserved Domains (1) summary
      cl21495
      Location:185 → 542
      DUF418; Protein of unknown function (DUF418)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9W4F7 Q9W4F7

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Other Literature Sources
    Molecular Biology Databases
    Research Materials
    Tools
    Miscellaneous