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    Acn Acinus [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 35173, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Acnprovided by FlyBase
    Official Full Name
    Acinusprovided by FlyBase
    Primary source
    FLYBASE:FBgn0263198
    Locus tag
    Dmel_CG10473
    See related
    AllianceGenome:FB:FBgn0263198
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    acn; Ba; CG10437; CG10473; dacn; dAcn; Dmel\CG10473; hkl; l(2)37Ba
    Summary
    Predicted to enable nucleic acid binding activity. Involved in RNA splicing and regulation of autophagy. Located in cytoplasm and nucleus. Part of catalytic step 2 spliceosome and precatalytic spliceosome. Is expressed in several structures, including CNS glial cell; adult head; central brain primordium; embryonic central brain neurons; and ganglia. Orthologous to human ACIN1 (apoptotic chromatin condensation inducer 1). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Acn in Genome Data Viewer
    Location:
    37B11-37B12; 2-54 cM
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (19045355..19048817)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (19045355..19048817)

    Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene mind bomb 2 Neighboring gene Catecholamines up Neighboring gene Tetratricopeptide repeat domain 19 Neighboring gene uncharacterized protein Neighboring gene lethal (2) 37Bb Neighboring gene Regulatory particle non-ATPase 3

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Optimized IMAC-IMAC protocol for phosphopeptide recovery from complex biological samples. Ye J, et al. J Proteome Res, 2010 Jul 2. PMID 20450229
    2. The antiapoptotic protein AAC-11 interacts with and regulates Acinus-mediated DNA fragmentation. Rigou P, et al. EMBO J, 2009 Jun 3. PMID 19387494, Free PMC Article
    3. The catecholamines up (Catsup) protein of Drosophila melanogaster functions as a negative regulator of tyrosine hydroxylase activity. Stathakis DG, et al. Genetics, 1999 Sep. PMID 10471719, Free PMC Article
    4. Stress-induced Cdk5 activity enhances cytoprotective basal autophagy in Drosophila melanogaster by phosphorylating acinus at serine(437). Nandi N, et al. Elife, 2017 Dec 11. PMID 29227247, Free PMC Article
    5. Acinus integrates AKT1 and subapoptotic caspase activities to regulate basal autophagy. Nandi N, et al. J Cell Biol, 2014 Oct 27. PMID 25332163, Free PMC Article

    See all (73) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. These data indicate that Cdk5 is required to maintain the protective role of basal autophagy in the initial responses to a subset of neurodegenerative challenges via phosphorylating Acinus at serine 437.
      Title: Stress-induced Cdk5 activity enhances cytoprotective basal autophagy in Drosophila melanogaster by phosphorylating acinus at serine(437).
    2. Study identified Drosophila acinus (dacn; hook-like), data show that dacn encodes a regulator of endosomal and autophagosomal dynamics, modulating developmental signaling and the cellular response to starvation.[Acinus]
      Title: Drosophila acinus encodes a novel regulator of endocytic and autophagic trafficking.
    3. AKT1 and caspase-dependent regulation of Acn stability adjusts basal autophagy levels.
      Title: Acinus integrates AKT1 and subapoptotic caspase activities to regulate basal autophagy.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables nucleic acid binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in RNA splicing IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in RNA splicing IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in mRNA splicing, via spliceosome IC
    Inferred by Curator
    more info
    		 PubMed 
    involved_in regulation of autophagy IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of ASAP complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of catalytic step 2 spliceosome HDA PubMed 
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of precatalytic spliceosome HDA PubMed 

    General protein information

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    Preferred Names
    acinus
    Names
    Acn-PA
    Acn-PB
    Acn-PC
    CG10473-PA
    CG10473-PB
    CG10473-PC
    drosophlia homolog of acinus
    hook-like
    lethal (2) 37Ba

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033779.5 Reference assembly

      Range
      19045355..19048817
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001273627.1 → NP_001260556.1  acinus, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001260556.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VJ12
      Conserved Domains (2) summary
      cd12432
      Location:444 → 530
      RRM_ACINU; RNA recognition motif in apoptotic chromatin condensation inducer in the nucleus (acinus) and similar proteins
      pfam16294
      Location:600 → 691
      RSB_motif; RNSP1-SAP18 binding (RSB) motif

    2. NM_136091.4 → NP_609935.1  acinus, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_609935.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VJ12
      Related
      FBpp0080689
      Conserved Domains (2) summary
      cd12432
      Location:444 → 530
      RRM_ACINU; RNA recognition motif in apoptotic chromatin condensation inducer in the nucleus (acinus) and similar proteins
      pfam16294
      Location:600 → 691
      RSB_motif; RNSP1-SAP18 binding (RSB) motif

    3. NM_165273.2 → NP_724153.1  acinus, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_724153.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VJ12
      Related
      FBpp0080688
      Conserved Domains (2) summary
      cd12432
      Location:444 → 530
      RRM_ACINU; RNA recognition motif in apoptotic chromatin condensation inducer in the nucleus (acinus) and similar proteins
      pfam16294
      Location:600 → 691
      RSB_motif; RNSP1-SAP18 binding (RSB) motif
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8MRH4 Q8MRH4
    Q9VJ12 Q9VJ12

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