Ada3 transcriptional Adaptor 3 [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: Ada3provided by FlyBase
Official Full Name: transcriptional Adaptor 3provided by FlyBase
Primary source: FLYBASE:FBgn0030891
Locus tag: Dmel_CG7098
See related: AllianceGenome:FB:FBgn0030891
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: ada3; ADA3; CG7098; dAda3; dADA3; DADA3; dik; Dmel\CG7098; HL-XIV
Summary: Enables chromatin binding activity. Involved in transcription initiation-coupled chromatin remodeling. Located in nucleus and polytene chromosome puff. Part of ATAC complex; H3 histone acetyltransferase complex; and SAGA complex. Colocalizes with euchromatin. Is expressed in several structures, including central brain primordium; embryonic central brain neurons; embryonic/larval midgut primordium; ganglia; and germline cell. Orthologous to human TADA3 (transcriptional adaptor 3). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	X	NC_004354.4 (18085761..18088418)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	X	NC_004354.3 (17979794..17982451)

Chromosome X - NC_004354.4 Genomic Context describing neighboring genes

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

This study reports the transcriptome analysis of Drosophila melanogaster dAda2a and dAda3 mutants, in which subunits of the ATAC acetyltransferase complex are affected.
Title: Genes of the ecdysone biosynthesis pathway are regulated by the dATAC histone acetyltransferase complex in Drosophila.
dADA3 plays a role in histone acetyltransferase complexes which acetylate H3 and H4 at specific residues
Title: Transcriptional adaptor ADA3 of Drosophila melanogaster is required for histone modification, position effect variegation, and transcription.

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

Function	Evidence Code	Pubs
enables chromatin binding	IDA Inferred from Direct Assay more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables transcription coactivator activity	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in chromatin remodeling	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
involved_in transcription initiation-coupled chromatin remodeling	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
part_of ATAC complex	IDA Inferred from Direct Assay more info	PubMed
part_of H3 histone acetyltransferase complex	IDA Inferred from Direct Assay more info	PubMed
part_of SAGA complex	IBA Inferred from Biological aspect of Ancestor more info
part_of SAGA complex	IDA Inferred from Direct Assay more info	PubMed
part_of SAGA complex	IPI Inferred from Physical Interaction more info	PubMed
colocalizes_with euchromatin	IDA Inferred from Direct Assay more info	PubMed
part_of histone acetyltransferase complex	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in polytene chromosome	IDA Inferred from Direct Assay more info	PubMed
located_in polytene chromosome puff	IDA Inferred from Direct Assay more info	PubMed

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