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    CCT8 Chaperonin containing TCP1 subunit 8 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 35882, updated on 9-Dec-2024

    Summary

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    Official Symbol
    CCT8provided by FlyBase
    Official Full Name
    Chaperonin containing TCP1 subunit 8provided by FlyBase
    Primary source
    FLYBASE:FBgn0284436
    Locus tag
    Dmel_CG8258
    See related
    AllianceGenome:FB:FBgn0284436
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    cct8; CG8258; Dmel\CG8258; l(2)03996; Q7K3J0_DROME; TCP-1theta; Tcp1-theta; TCP1-theta
    Summary
    Predicted to enable unfolded protein binding activity. Predicted to be involved in protein folding. Located in plasma membrane. Is expressed in several structures, including Malpighian tubule primordium; adult brain cell body rind; embryonic/larval midgut primordium; gut section; and mesoderm. Orthologous to human CCT8 (chaperonin containing TCP1 subunit 8). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See CCT8 in Genome Data Viewer
    Location:
    44F5-44F5; 2-59 cM
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (8904844..8906990, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (4792349..4794495, complement)

    Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene MRG/MORF4L binding protein Neighboring gene G protein gamma subunit 1 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene Phosphoglucose isomerase

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Nucleocytoplasmic Proteomic Analysis Uncovers eRF1 and Nonsense-Mediated Decay as Modifiers of ALS/FTD C9orf72 Toxicity. Ortega JA, et al. Neuron, 2020 Apr 8. PMID 32059759, Free PMC Article
    2. Structures of the Gβ-CCT and PhLP1-Gβ-CCT complexes reveal a mechanism for G-protein β-subunit folding and Gβγ dimer assembly. Plimpton RL, et al. Proc Natl Acad Sci U S A, 2015 Feb 24. PMID 25675501, Free PMC Article
    3. Chaperonin TRiC/CCT supports mitotic exit and entry into endocycle in Drosophila. Ohhara Y, et al. PLoS Genet, 2019 Apr. PMID 31034473, Free PMC Article
    4. Misato Controls Mitotic Microtubule Generation by Stabilizing the TCP-1 Tubulin Chaperone Complex [corrected]. Palumbo V, et al. Curr Biol, 2015 Jun 29. PMID 26096973, Free PMC Article
    5. TRiC/CCT chaperonins are essential for organ growth by interacting with insulin/TOR signaling in Drosophila. Kim AR, et al. Oncogene, 2019 Jun. PMID 30792539, Free PMC Article

    See all (66) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP hydrolysis activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP-dependent protein folding chaperone IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables unfolded protein binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables unfolded protein binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in protein folding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein folding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    part_of chaperonin-containing T-complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane HDA PubMed 

    General protein information

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    Preferred Names
    chaperonin containing TCP1 subunit 8
    Names
    CCT8-PA
    CG8258-PA
    lethal (2) 03996

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033778.4 Reference assembly

      Range
      8904844..8906990 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_136574.3 → NP_610418.1  chaperonin containing TCP1 subunit 8 [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_610418.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q7K3J0
      Related
      FBpp0087764
      Conserved Domains (2) summary
      cd03341
      Location:20 → 529
      TCP1_theta; TCP-1 (CTT or eukaryotic type II) chaperonin family, theta subunit. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings. In contrast to bacterial group I chaperonins ...
      pfam00118
      Location:40 → 529
      Cpn60_TCP1; TCP-1/cpn60 chaperonin family
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q7K3J0 Q7K3J0

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