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    Cpsf6 Cleavage and polyadenylation specific factor 6 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 38937, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Cpsf6provided by FlyBase
    Official Full Name
    Cleavage and polyadenylation specific factor 6provided by FlyBase
    Primary source
    FLYBASE:FBgn0035872
    Locus tag
    Dmel_CG7185
    See related
    AllianceGenome:FB:FBgn0035872
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CF I[[m]]68; CFI68; CFIm68; CFlm-68k; cg7185; CG7185; CPSF6; dCPSF6; Dmel\CG7185
    Summary
    Enables mRNA binding activity. Involved in regulation of alternative mRNA splicing, via spliceosome. Located in nucleus. Is expressed in several structures, including adult head; central brain primordium; embryonic/larval midgut primordium; ganglia; and larval nervous system. Orthologous to human CPSF6 (cleavage and polyadenylation specific factor 6). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Cpsf6 in Genome Data Viewer
    Location:
    66C5-66C6; 3-24 cM
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (8310493..8315502, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (8303593..8308602, complement)

    Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene Gustatory receptor 66a Neighboring gene long non-coding RNA:CR45409 Neighboring gene Bax Inhibitor-1 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. SWI/SNF interacts with cleavage and polyadenylation factors and facilitates pre-mRNA 3' end processing. Yu S, et al. Nucleic Acids Res, 2018 Sep 19. PMID 29860334, Free PMC Article
    2. A developmental mechanism to regulate alternative polyadenylation in an adult stem cell lineage. Gallicchio L, et al. Genes Dev, 2024 Aug 20. PMID 39111825,
    3. Positive selection in nucleoporins challenges constraints on early expressed genes in Drosophila development. Mensch J, et al. Genome Biol Evol, 2013. PMID 24171912, Free PMC Article
    4. Use of circular RNAs as markers of readthrough transcription to identify factors regulating cleavage/polyadenylation events. Liang D, et al. Methods, 2021 Dec. PMID 33882363, Free PMC Article
    5. Molecular Regulation of Alternative Polyadenylation (APA) within the Drosophila Nervous System. Vallejos Baier R, et al. J Mol Biol, 2017 Oct 27. PMID 28366829, Free PMC Article

    See all (58) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. TORC1 signaling inhibits CDK8 and DOA kinases, which directly phosphorylate CPSF6, a component of the cleavage and polyadenylation (CPA) complex.
      Title: The TORC1-Regulated CPA Complex Rewires an RNA Processing Network to Drive Autophagy and Metabolic Reprogramming.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables RNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables mRNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables mRNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables mRNA binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in mRNA alternative polyadenylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of alternative mRNA splicing, via spliceosome HMP PubMed 
    Component Evidence Code Pubs
    part_of mRNA cleavage and polyadenylation specificity factor complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus HDA PubMed 
    located_in nucleus IC
    Inferred by Curator
    more info
    		 PubMed 
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    cleavage and polyadenylation specific factor 6
    Names
    CG7185-PA
    CG7185-PB
    Cpsf6-PA
    Cpsf6-PB

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_037436.4 Reference assembly

      Range
      8310493..8315502 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001259736.1 → NP_001246665.1  cleavage and polyadenylation specific factor 6, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001246665.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      M9NF33
      Conserved Domains (1) summary
      cd12643
      Location:94 → 170
      RRM_CFIm68; RNA recognition motif of pre-mRNA cleavage factor Im 68 kDa subunit (CFIm68 or CPSF6) and similar proteins

    2. NM_139949.3 → NP_648206.1  cleavage and polyadenylation specific factor 6, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_648206.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q95TS9, Q9VSH4
      Related
      FBpp0076433
      Conserved Domains (1) summary
      cd12643
      Location:94 → 170
      RRM_CFIm68; RNA recognition motif of pre-mRNA cleavage factor Im 68 kDa subunit (CFIm68 or CPSF6) and similar proteins
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    M9NF33 M9NF33
    Q9VSH4.2 Q9VSH4

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
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