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    mrn marionette [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 39688, updated on 9-Dec-2024

    Summary

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    Official Symbol
    mrnprovided by FlyBase
    Official Full Name
    marionetteprovided by FlyBase
    Primary source
    FLYBASE:FBgn0261109
    Locus tag
    Dmel_CG7764
    See related
    AllianceGenome:FB:FBgn0261109
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    154538_at; anon-WO0118547.648; CG7764; Dmel\CG7764; Dmp52; l(3)E35; ms(3)nc16; nc16; p52; Tfb2; TFB2
    Summary
    Enables ATPase activator activity. Involved in nucleotide-excision repair; response to UV-B; and transcription by RNA polymerase II. Located in nucleus. Part of transcription factor TFIIH core complex and transcription factor TFIIH holo complex. Is expressed in several structures, including embryonic/larval midgut; epithelium; larval brain; and larval nervous system. Orthologous to human GTF2H4 (general transcription factor IIH subunit 4). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See mrn in Genome Data Viewer
    Location:
    71E1-71E1; 3-43 cM
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (15578769..15580537, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (15571869..15573637, complement)

    Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene drop out Neighboring gene UFM1 specific peptidase 2 Neighboring gene uncharacterized protein Neighboring gene aaRS-interacting multifunctional protein 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Activation of recombinant trp by thapsigargin in Sf9 insect cells. Vaca L, et al. Am J Physiol, 1994 Nov. PMID 7977711
    2. DNA repair and transcriptional deficiencies caused by mutations in the Drosophila p52 subunit of TFIIH generate developmental defects and chromosome fragility. Fregoso M, et al. Mol Cell Biol, 2007 May. PMID 17339330, Free PMC Article
    3. Telomere capping in Drosophila: dealing with chromosome ends that most resemble DNA breaks. Rong YS. Chromosoma, 2008 Jun. PMID 18193446
    4. The genetic depletion or the triptolide inhibition of TFIIH in p53-deficient cells induces a JNK-dependent cell death in Drosophila. Villicaña C, et al. J Cell Sci, 2013 Jun 1. PMID 23549790
    5. Physical and functional interactions between Drosophila homologue of Swc6/p18Hamlet subunit of the SWR1/SRCAP chromatin-remodeling complex with the DNA repair/transcription factor TFIIH. Herrera-Cruz M, et al. J Biol Chem, 2012 Sep 28. PMID 22865882, Free PMC Article

    See all (50) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. the enhanced apoptosis caused by the simultaneous depletion of Dp53 and Dmp52 is absolutely JNK-dependent.
      Title: The genetic depletion or the triptolide inhibition of TFIIH in p53-deficient cells induces a JNK-dependent cell death in Drosophila.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables ATPase activator activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables ATPase activator activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables double-stranded DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in RNA polymerase II promoter clearance ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    involved_in nucleotide-excision repair IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in nucleotide-excision repair IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in nucleotide-excision repair IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in nucleotide-excision repair IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in response to UV-B IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in transcription by RNA polymerase II IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in transcription initiation at RNA polymerase II promoter ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    involved_in transcription open complex formation at RNA polymerase II promoter ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of transcription factor TFIIH core complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of transcription factor TFIIH core complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of transcription factor TFIIH core complex IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    part_of transcription factor TFIIH core complex ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    part_of transcription factor TFIIH holo complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of transcription factor TFIIH holo complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of transcription factor TFIIH holo complex IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    part_of transcription factor TFIIH holo complex ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    marionette
    Names
    CG7764-PA
    Tfb2
    marionnette
    mrn-PA

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_037436.4 Reference assembly

      Range
      15578769..15580537 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_140523.4 → NP_648780.1  marionette [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_648780.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VUR1
      Related
      FBpp0075348
      Conserved Domains (1) summary
      pfam03849
      Location:39 → 403
      Tfb2; Transcription factor Tfb2
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q95TQ5 Q95TQ5
    Q9VUR1 Q9VUR1

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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