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    Noc3 Nucleolar complex protein 3 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 40870, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Noc3provided by FlyBase
    Official Full Name
    Nucleolar complex protein 3provided by FlyBase
    Primary source
    FLYBASE:FBgn0037489
    Locus tag
    Dmel_CG1234
    See related
    AllianceGenome:FB:FBgn0037489
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG1234; Dmel\CG1234; NOC3
    Summary
    Predicted to enable chromatin binding activity. Predicted to be involved in DNA replication initiation. Predicted to be located in nucleus. Predicted to be part of Noc2p-Noc3p complex. Predicted to be active in nucleolus. Is expressed in several structures, including Malpighian tubule primordium; anterior endoderm; embryonic/larval midgut primordium; gut section; and hindgut proper primordium. Orthologous to human NOC3L (NOC3 like DNA replication regulator). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Noc3 in Genome Data Viewer
    Location:
    84D3-84D3; 3-48 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (7244232..7246969, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (3069954..3072691, complement)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene thawb Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Reduction of nucleolar NOC1 leads to the accumulation of pre-rRNAs and induces Xrp1, affecting growth and resulting in cell competition. Destefanis F, et al. J Cell Sci, 2022 Dec 1. PMID 36314272, Free PMC Article
    2. Drosophila Myc interacts with host cell factor (dHCF) to activate transcription and control growth. Furrer M, et al. J Biol Chem, 2010 Dec 17. PMID 20937797, Free PMC Article
    3. Interactions of drosophila cryptochrome. Ozcelik G, et al. Photochem Photobiol, 2024 Sep-Oct. PMID 38314442
    4. Identification of Drosophila mitotic genes by combining co-expression analysis and RNA interference. Somma MP, et al. PLoS Genet, 2008 Jul 18. PMID 18797514, Free PMC Article
    5. An Integrative Analysis of the InR/PI3K/Akt Network Identifies the Dynamic Response to Insulin Signaling. Vinayagam A, et al. Cell Rep, 2016 Sep 13. PMID 27626673, Free PMC Article

    See all (34) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables chromatin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in DNA replication initiation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    part_of Noc2p-Noc3p complex ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    is_active_in nucleolus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    nucleolar complex protein 3
    Names
    CG1234-PA
    Noc3-PA
    nucleolar complex protein-3

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      7244232..7246969 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_141453.5 → NP_649710.1  nucleolar complex protein 3 [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_649710.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9VI82
      Related
      FBpp0081117
      Conserved Domains (3) summary
      COG5117
      Location:228 → 727
      NOC3; Protein involved in the nuclear export of pre-ribosomes [Translation, ribosomal structure and biogenesis / Intracellular trafficking and secretion]
      pfam03914
      Location:574 → 727
      CBF; CBF/Mak21 family
      pfam07540
      Location:235 → 330
      NOC3p; Nucleolar complex-associated protein
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9VI82.1 Q9VI82

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