aralar1 aralar1 [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: aralar1provided by FlyBase
Official Full Name: aralar1provided by FlyBase
Primary source: FLYBASE:FBgn0028646
Locus tag: Dmel_CG2139
See related: AllianceGenome:FB:FBgn0028646
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: aralar; Aralar; Aralar1; BcDNA:GH07418; CABP1; CG2139; DmAralar; Dmel\CG2139
Summary: Enables aspartate:glutamate, proton antiporter activity and gamma-aminobutyric acid:proton symporter activity. Involved in carboxylic acid transport and malate-aspartate shuttle. Located in mitochondrion. Is expressed in several structures, including adult head; adult heart; amnioserosa; embryonic proventriculus; and germline cell. Used to study neonatal-onset type II citrullinemia. Human ortholog(s) of this gene implicated in Asperger syndrome; adult-onset type II citrullinemia; autistic disorder; developmental and epileptic encephalopathy 39; and neonatal-onset type II citrullinemia. Orthologous to several human genes including SLC25A12 (solute carrier family 25 member 12). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Genomic context

Location:: 99F4-99F5; 3-100 cM

Exon count:: 13

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	3R	NT_033777.3 (30445635..30455867, complement)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	3R	NT_033777.2 (26271357..26281589, complement)

Chromosome 3R - NT_033777.3 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The mitochondrial aspartate/glutamate carrier (AGC or Aralar1) isoforms in D. melanogaster: biochemical characterization, gene structure, and evolutionary analysis.
Title: The mitochondrial aspartate/glutamate carrier (AGC or Aralar1) isoforms in D. melanogaster: biochemical characterization, gene structure, and evolutionary analysis.

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Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
enables L-aspartate transmembrane transporter activity	IBA Inferred from Biological aspect of Ancestor more info
enables L-glutamate transmembrane transporter activity	IBA Inferred from Biological aspect of Ancestor more info
enables aspartate:glutamate, proton antiporter activity	IDA Inferred from Direct Assay more info	PubMed
enables calcium ion binding	IEA Inferred from Electronic Annotation more info
enables calcium ion binding	ISS Inferred from Sequence or Structural Similarity more info
enables gamma-aminobutyric acid:proton symporter activity	IGI Inferred from Genetic Interaction more info	PubMed
enables identical protein binding	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
involved_in L-aspartate transmembrane transport	IDA Inferred from Direct Assay more info	PubMed
involved_in L-glutamate transmembrane transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in L-glutamate transmembrane transport	IDA Inferred from Direct Assay more info	PubMed
involved_in aspartate transmembrane transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in gamma-aminobutyric acid transport	IGI Inferred from Genetic Interaction more info	PubMed
involved_in gluconeogenesis	ISS Inferred from Sequence or Structural Similarity more info
involved_in malate-aspartate shuttle	IBA Inferred from Biological aspect of Ancestor more info
involved_in malate-aspartate shuttle	IGI Inferred from Genetic Interaction more info	PubMed
involved_in mitochondrial calcium ion transmembrane transport	IEA Inferred from Electronic Annotation more info
involved_in transmembrane transport	IEA Inferred from Electronic Annotation more info
involved_in wound healing	HMP more info	PubMed

Component	Evidence Code	Pubs
is_active_in mitochondrial inner membrane	IC Inferred by Curator more info	PubMed
located_in mitochondrion	HDA more info	PubMed

General protein information

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Preferred Names: aralar1

Names: Aralar1; CG2139-PA; CG2139-PB; CG2139-PC; CG2139-PD; CG2139-PE; CG2139-PF; aralar1-PA; aralar1-PB; aralar1-PC; aralar1-PD; aralar1-PE; aralar1-PF

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NT_033777.3 Reference assembly

Range

30445635..30455867 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_170485.2 → NP_733364.1 aralar1, isoform C [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_733364.1

Status: REVIEWED

UniProtKB/Swiss-Prot

A4V3N6, Q95TN5, Q9U5V8, Q9VA72, Q9VA73, Q9VA74

UniProtKB/TrEMBL

D0IQH2

Related

FBpp0085054

Conserved Domains (5) summary

PTZ00169
Location:346 → 619

PTZ00169; ADP/ATP transporter on adenylate translocase; Provisional

pfam00153
Location:338 → 436

Mito_carr; Mitochondrial carrier protein

pfam13499
Location:35 → 99

EF-hand_7; EF-hand domain pair

pfam13833
Location:51 → 99

EF-hand_8; EF-hand domain pair

cl08302
Location:84 → 135

EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
NM_001260439.1 → NP_001247368.1 aralar1, isoform E [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001247368.1

Status: REVIEWED

UniProtKB/TrEMBL

A0A0B4K6V1, D0IQH2

Conserved Domains (5) summary

PTZ00169
Location:358 → 631

PTZ00169; ADP/ATP transporter on adenylate translocase; Provisional

pfam00153
Location:350 → 448

Mito_carr; Mitochondrial carrier protein

pfam13499
Location:35 → 99

EF-hand_7; EF-hand domain pair

pfam13833
Location:51 → 99

EF-hand_8; EF-hand domain pair

cl08302
Location:84 → 135

EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
NM_170487.3 → NP_733366.2 aralar1, isoform B [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_733366.2

Status: REVIEWED

UniProtKB/TrEMBL

D0IQH2

Related

FBpp0085055

Conserved Domains (5) summary

PTZ00169
Location:330 → 603

PTZ00169; ADP/ATP transporter on adenylate translocase; Provisional

pfam00153
Location:322 → 420

Mito_carr; Mitochondrial carrier protein

pfam13499
Location:19 → 83

EF-hand_7; EF-hand domain pair

pfam13833
Location:35 → 83

EF-hand_8; EF-hand domain pair

cl08302
Location:68 → 119

EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
NM_143538.3 → NP_651795.2 aralar1, isoform A [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_651795.2

Status: REVIEWED

UniProtKB/TrEMBL

D0IQH2

Related

FBpp0085056

Conserved Domains (5) summary

PTZ00169
Location:333 → 606

PTZ00169; ADP/ATP transporter on adenylate translocase; Provisional

pfam00153
Location:325 → 423

Mito_carr; Mitochondrial carrier protein

pfam13499
Location:22 → 86

EF-hand_7; EF-hand domain pair

pfam13833
Location:38 → 86

EF-hand_8; EF-hand domain pair

cl08302
Location:71 → 122

EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
NM_001276178.1 → NP_001263107.1 aralar1, isoform F [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001263107.1

Status: REVIEWED

UniProtKB/TrEMBL

A0A0B4KHW3, D0IQH2

Conserved Domains (5) summary

PTZ00169
Location:333 → 606

PTZ00169; ADP/ATP transporter on adenylate translocase; Provisional

pfam00153
Location:325 → 423

Mito_carr; Mitochondrial carrier protein

pfam13499
Location:22 → 86

EF-hand_7; EF-hand domain pair

pfam13833
Location:38 → 86

EF-hand_8; EF-hand domain pair

cl08302
Location:71 → 122

EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
NM_170486.2 → NP_733365.1 aralar1, isoform D [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_733365.1

Status: REVIEWED

UniProtKB/TrEMBL

D0IQH2

Related

FBpp0085057

Conserved Domains (5) summary

PTZ00169
Location:333 → 606

PTZ00169; ADP/ATP transporter on adenylate translocase; Provisional

pfam00153
Location:325 → 423

Mito_carr; Mitochondrial carrier protein

pfam13499
Location:22 → 86

EF-hand_7; EF-hand domain pair

pfam13833
Location:38 → 86

EF-hand_8; EF-hand domain pair

cl08302
Location:71 → 122

EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...