U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    Cdk1 Cyclin-dependent kinase 1 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 34411, updated on 9-Dec-2024

    Summary

    Official Symbol
    Cdk1provided by FlyBase
    Official Full Name
    Cyclin-dependent kinase 1provided by FlyBase
    Primary source
    FLYBASE:FBgn0004106
    Locus tag
    Dmel_CG5363
    See related
    AllianceGenome:FB:FBgn0004106
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    5363; cdc; cdc2; Cdc2; CDC2; cdc2Dm; CDCDm; Cdk-1; cdk1; CDK1; CDK1/CDC2; CG5363; Dcdc2; dCdk1; Dm cdc2; Dmcdc2; DmCdc2; DmCdk1; Dmel\CG5363; group 4; l(2)31Eh
    Summary
    Enables cyclin-dependent protein serine/threonine kinase activity. Involved in several processes, including mitotic G2 DNA damage checkpoint signaling; mitotic cell cycle phase transition; and oogenesis. Located in fusome. Is expressed in several structures, including embryonic/larval midgut primordium; ganglia; head epidermis primordium; imaginal disc; and mesoderm. Human ortholog(s) of this gene implicated in breast cancer; cervical cancer; and urinary bladder cancer. Orthologous to human CDK1 (cyclin dependent kinase 1). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See Cdk1 in Genome Data Viewer
    Location:
    31D11-31D11; 2-41 cM
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (10384739..10386262, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (10384739..10386262, complement)

    Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene defective proboscis extension response 19 Neighboring gene garnysstan Neighboring gene uncharacterized protein Neighboring gene mitochondrial ribosomal protein S7 Neighboring gene daughterless Neighboring gene antisense RNA:CR45789

    Genomic regions, transcripts, and products

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables cyclin-dependent protein serine/threonine kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables cyclin-dependent protein serine/threonine kinase activity IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    enables cyclin-dependent protein serine/threonine kinase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein kinase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein serine/threonine kinase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in G1/S transition of mitotic cell cycle IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in G2/M transition of mitotic cell cycle IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in G2/M transition of mitotic cell cycle IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in G2/M transition of mitotic cell cycle IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in asymmetric neuroblast division IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in embryonic development via the syncytial blastoderm IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in follicle cell of egg chamber development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in germarium-derived cystoblast division IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in male meiotic nuclear division IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in mitotic G2 DNA damage checkpoint signaling IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in mitotic G2 DNA damage checkpoint signaling IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in mitotic G2/M transition checkpoint IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in protein phosphorylation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in regulation of DNA-templated DNA replication initiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in regulation of mitotic cell cycle phase transition IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in regulation of protein localization IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in spermatogonial cell division IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in fusome IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
     

    General protein information

    Preferred Names
    Cyclin-dependent kinase 1
    Names
    CG5363-PA
    Cdk1-PA
    cdc2
    cdc2 kinase
    cell division control
    cyclin dependent kinase
    cyclin-dependent kinase
    protein 2
    NP_476797.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033779.5 Reference assembly

      Range
      10384739..10386262 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_057449.4NP_476797.1  Cyclin-dependent kinase 1 [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_476797.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A0ANT1, P23572, Q86FT5, Q86FT6, Q86FT7, Q86FT8, Q86FT9, Q9TX68, Q9TX69, Q9TX70, Q9TX71, Q9TX72, Q9TX73, Q9TX74, Q9VKX5
      UniProtKB/TrEMBL
      C0MJ66
      Related
      FBpp0079641
      Conserved Domains (1) summary
      cd07861
      Location:3287
      STKc_CDK1_euk; Catalytic domain of the Serine/Threonine Kinase, Cyclin-Dependent protein Kinase 1 from higher eukaryotes