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    Ama Amalgam [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 40831, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Amaprovided by FlyBase
    Official Full Name
    Amalgamprovided by FlyBase
    Primary source
    FLYBASE:FBgn0000071
    Locus tag
    Dmel_CG2198
    See related
    AllianceGenome:FB:FBgn0000071
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    ama; AMA; BG:DS00276.6; CG2198; CT7244; Dmel\CG2198; M109
    Summary
    Enables receptor ligand activity. Involved in several processes, including heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules; positive regulation of epidermal growth factor receptor signaling pathway; and positive regulation of glial cell proliferation. Located in extracellular space and plasma membrane. Is expressed in several structures, including anlage in statu nascendi; fat body; head epidermis primordium; mesoderm; and sense organ. Human ortholog(s) of this gene implicated in ovarian cancer. Orthologous to several human genes including IGLON5 (IgLON family member 5); NEGR1 (neuronal growth regulator 1); and NTM (neurotrimin). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Ama in Genome Data Viewer
    Location:
    84A5-84A5; 3-48 cM
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (6762593..6765261)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (2588315..2590983)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene zerknullt Neighboring gene bicoid Neighboring gene long non-coding RNA:CR45593 Neighboring gene long non-coding RNA:CR44930 Neighboring gene long non-coding RNA::CR42721 Neighboring gene mir-993 stem loop

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Amalgam plays a dual role in controlling the number of leg muscle progenitors and regulating their interactions with the developing Drosophila tendon. Moucaud B, et al. PLoS Biol, 2024 Oct. PMID 39374263, Free PMC Article
    2. The quaternary structure of amalgam, a Drosophila neuronal adhesion protein, explains its dual adhesion properties. Zeev-Ben-Mordehai T, et al. Biophys J, 2009 Oct 21. PMID 19843464, Free PMC Article
    3. Immunology. Insects diversify one molecule to serve two systems. Du Pasquier L. Science, 2005 Sep 16. PMID 16166509
    4. Amalgam, an axon guidance Drosophila adhesion protein belonging to the immunoglobulin superfamily: over-expression, purification and biophysical characterization. Zeev-Ben-Mordehai T, et al. Protein Expr Purif, 2009 Feb. PMID 18938249
    5. Lachesin: an immunoglobulin superfamily protein whose expression correlates with neurogenesis in grasshopper embryos. Karlstrom RO, et al. Development, 1993 Jun. PMID 8223276

    See all (88) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Amalgam plays a dual role in controlling the number of leg muscle progenitors and regulating their interactions with the developing Drosophila tendon.
      Title: Amalgam plays a dual role in controlling the number of leg muscle progenitors and regulating their interactions with the developing Drosophila tendon.
    2. Amalgam regulates the receptor tyrosine kinase pathway through Sprouty in glial cell development in the Drosophila larval brain.
      Title: Amalgam regulates the receptor tyrosine kinase pathway through Sprouty in glial cell development in the Drosophila larval brain.
    3. In conjunction with its receptor Neurotactin (Nrt) and the effector kinase Abelson tyrosine kinase (Abl), Ama is necessary in parallel to the cell-autonomous Dfd pathway for the correct specification of the maxillary identity of NB6-4
      Title: Cell-Autonomous and Non-cell-autonomous Function of Hox Genes Specify Segmental Neuroblast Identity in the Gnathal Region of the Embryonic CNS in Drosophila.
    4. In this study we performed a comprehensive biophysical characterization of the multidomain Drosophila adhesion glycoprotein Ama, and determined its 3D structure in solution to 20 A resolution
      Title: The quaternary structure of amalgam, a Drosophila neuronal adhesion protein, explains its dual adhesion properties.
    5. amalgam, neurotactin and the Abelson tyrosine kinase interact and affect axon pathfinding
      Title: Interactions between the secreted protein Amalgam, its transmembrane receptor Neurotactin and the Abelson tyrosine kinase affect axon pathfinding.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables receptor ligand activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    involved_in maintenance of blood-brain barrier IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of epidermal growth factor receptor signaling pathway IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in positive regulation of glial cell migration IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of glial cell proliferation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in extracellular space IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    amalgam
    Names
    Ama-PA
    Ama-PB
    Ama-PC
    CG2198-PA
    CG2198-PB
    CG2198-PC
    amalgam shotgun

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      6762593..6765261
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_169160.1 → NP_731114.2  amalgam, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_731114.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q7KSX2
      Related
      FBpp0081135, FBtr0081618
      Conserved Domains (4) summary
      smart00408
      Location:161 → 223
      IGc2; Immunoglobulin C-2 Type
      smart00410
      Location:154 → 234
      IG_like; Immunoglobulin like
      pfam07679
      Location:33 → 143
      I-set; Immunoglobulin I-set domain
      cl11960
      Location:37 → 127
      Ig; Immunoglobulin domain

    2. NM_057231.4 → NP_476579.1  amalgam, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_476579.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P15364, Q9V3A5
      UniProtKB/TrEMBL
      A4V2I0
      Related
      FBpp0081136
      Conserved Domains (4) summary
      smart00408
      Location:153 → 215
      IGc2; Immunoglobulin C-2 Type
      smart00410
      Location:146 → 226
      IG_like; Immunoglobulin like
      pfam07679
      Location:25 → 135
      I-set; Immunoglobulin I-set domain
      cl11960
      Location:29 → 119
      Ig; Immunoglobulin domain

    3. NM_176412.2 → NP_788589.1  amalgam, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_788589.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P15364, Q9V3A5
      UniProtKB/TrEMBL
      A4V2I0
      Related
      FBpp0081137
      Conserved Domains (4) summary
      smart00408
      Location:153 → 215
      IGc2; Immunoglobulin C-2 Type
      smart00410
      Location:146 → 226
      IG_like; Immunoglobulin like
      pfam07679
      Location:25 → 135
      I-set; Immunoglobulin I-set domain
      cl11960
      Location:29 → 119
      Ig; Immunoglobulin domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A4V2I0 A4V2I0
    P15364.2 P15364
    Q7KSX2 Q7KSX2

    Gene LinkOut

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