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    CG10237 uncharacterized protein [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 35222, updated on 9-Dec-2024

    Summary

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    Official Symbol
    CG10237provided by FlyBase
    Official Full Name
    uncharacterized proteinprovided by FlyBase
    Primary source
    FLYBASE:FBgn0032783
    Locus tag
    Dmel_CG10237
    See related
    AllianceGenome:FB:FBgn0032783
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    Dmel\CG10237
    Summary
    Predicted to enable phosphatidylinositol bisphosphate binding activity. Predicted to be involved in intermembrane lipid transfer. Predicted to be located in late endosome. Is expressed in adult head and organism. Orthologous to human TTPAL (alpha tocopherol transfer protein like). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See CG10237 in Genome Data Viewer
    Location:
    37E1-37E1; 2-54 cM
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (19435850..19442727, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (19435850..19442727, complement)

    Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene RtcB RNA ligase Neighboring gene Rab9 Neighboring gene Ran GTPase activating protein Neighboring gene Heparan sulfate 2-O-sulfotransferase Neighboring gene Topoisomerase 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Large-scale selective sweep among Segregation Distorter chromosomes in African populations of Drosophila melanogaster. Presgraves DC, et al. PLoS Genet, 2009 May. PMID 19412335, Free PMC Article
    2. A direct role for cohesin in gene regulation and ecdysone response in Drosophila salivary glands. Pauli A, et al. Curr Biol, 2010 Oct 26. PMID 20933422, Free PMC Article
    3. Genome-wide analysis in Drosophila reveals diet-by-gene interactions and uncovers diet-responsive genes. Francis D, et al. G3 (Bethesda), 2021 Sep 27. PMID 34568906, Free PMC Article
    4. Microarray analysis and organization of circadian gene expression in Drosophila. McDonald MJ, et al. Cell, 2001 Nov 30. PMID 11733057
    5. Proteomic Analysis of the Ubiquitin Landscape in the Drosophila Embryonic Nervous System and the Adult Photoreceptor Cells. Ramirez J, et al. PLoS One, 2015. PMID 26460970, Free PMC Article

    See all (27) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables phosphatidylinositol bisphosphate binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables phosphatidylinositol bisphosphate binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in intermembrane lipid transfer ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    located_in late endosome ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    uncharacterized protein
    Names
    CG10237-PA
    CG10237-PB
    CG10237-PC
    CG10237-PD
    CG10237-PE

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033779.5 Reference assembly

      Range
      19435850..19442727 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001259162.2 → NP_001246091.1  uncharacterized protein Dmel_CG10237, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001246091.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      C6TP94, Q9I7M3
      Conserved Domains (2) summary
      smart01100
      Location:45 → 92
      CRAL_TRIO_N; CRAL/TRIO, N-terminal domain
      cd00170
      Location:114 → 267
      SEC14; Sec14p-like lipid-binding domain. Found in secretory proteins, such as S. cerevisiae phosphatidylinositol transfer protein (Sec14p), and in lipid regulated proteins such as RhoGAPs, RhoGEFs and neurofibromin (NF1). SEC14 domain of Dbl is known to ...

    2. NM_165299.2 → NP_724193.1  uncharacterized protein Dmel_CG10237, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_724193.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      C6TP94, Q9I7M3
      Related
      FBpp0080748
      Conserved Domains (2) summary
      smart01100
      Location:45 → 92
      CRAL_TRIO_N; CRAL/TRIO, N-terminal domain
      cd00170
      Location:114 → 267
      SEC14; Sec14p-like lipid-binding domain. Found in secretory proteins, such as S. cerevisiae phosphatidylinositol transfer protein (Sec14p), and in lipid regulated proteins such as RhoGAPs, RhoGEFs and neurofibromin (NF1). SEC14 domain of Dbl is known to ...

    3. NM_136123.3 → NP_609967.1  uncharacterized protein Dmel_CG10237, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_609967.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      C6TP94, Q95RD3, Q9VIW5
      Related
      FBpp0080749
      Conserved Domains (2) summary
      smart01100
      Location:68 → 115
      CRAL_TRIO_N; CRAL/TRIO, N-terminal domain
      cd00170
      Location:137 → 290
      SEC14; Sec14p-like lipid-binding domain. Found in secretory proteins, such as S. cerevisiae phosphatidylinositol transfer protein (Sec14p), and in lipid regulated proteins such as RhoGAPs, RhoGEFs and neurofibromin (NF1). SEC14 domain of Dbl is known to ...

    4. NM_165298.2 → NP_724192.1  uncharacterized protein Dmel_CG10237, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_724192.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      C6TP94, Q8INW5
      Related
      FBpp0080750
      Conserved Domains (2) summary
      smart01100
      Location:50 → 97
      CRAL_TRIO_N; CRAL/TRIO, N-terminal domain
      cd00170
      Location:119 → 272
      SEC14; Sec14p-like lipid-binding domain. Found in secretory proteins, such as S. cerevisiae phosphatidylinositol transfer protein (Sec14p), and in lipid regulated proteins such as RhoGAPs, RhoGEFs and neurofibromin (NF1). SEC14 domain of Dbl is known to ...

    5. NM_001273648.1 → NP_001260577.1  uncharacterized protein Dmel_CG10237, isoform E [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001260577.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      C6TP94, Q8INW5
      Conserved Domains (2) summary
      smart01100
      Location:50 → 97
      CRAL_TRIO_N; CRAL/TRIO, N-terminal domain
      cd00170
      Location:119 → 272
      SEC14; Sec14p-like lipid-binding domain. Found in secretory proteins, such as S. cerevisiae phosphatidylinositol transfer protein (Sec14p), and in lipid regulated proteins such as RhoGAPs, RhoGEFs and neurofibromin (NF1). SEC14 domain of Dbl is known to ...
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8INW5 Q8INW5
    Q9I7M3 Q9I7M3
    Q9VIW5 Q9VIW5

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