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    CG18135 uncharacterized protein [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 40073, updated on 9-Dec-2024

    Summary

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    Official Symbol
    CG18135provided by FlyBase
    Official Full Name
    uncharacterized proteinprovided by FlyBase
    Primary source
    FLYBASE:FBgn0036837
    Locus tag
    Dmel_CG18135
    See related
    AllianceGenome:FB:FBgn0036837
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    Dmel\CG18135
    Summary
    Enables myosin binding activity. Involved in sexual reproduction. Located in extracellular space. Is expressed in several structures, including adult head; amnioserosa; embryonic anal pad; embryonic/larval midgut; and sense organ. Orthologous to human GPCPD1 (glycerophosphocholine phosphodiesterase 1). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See CG18135 in Genome Data Viewer
    Location:
    75F2-75F2; 3-45 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (18990026..18998283, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (18983126..18991383, complement)

    Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene SET and MYND domain containing, arthropod-specific, member 2 Neighboring gene naked cuticle Neighboring gene long non-coding RNA:CR45940

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. A novel insertional allele of the CG18135 gene is associated with severe mutant phenotypes in Drosophila melanogaster. Ratiu AC, et al. Front Genet, 2024. PMID 38957808, Free PMC Article
    2. The chromatin remodelers ISWI and ACF1 directly repress Wingless transcriptional targets. Liu YI, et al. Dev Biol, 2008 Nov 1. PMID 18786525, Free PMC Article
    3. An RDH-Plin2 axis modulates lipid droplet size by antagonizing Bmm lipase. Zhao X, et al. EMBO Rep, 2022 Feb 3. PMID 35132760, Free PMC Article
    4. CLOCKWORK ORANGE promotes CLOCK-CYCLE activation via the putative Drosophila ortholog of CLOCK INTERACTING PROTEIN CIRCADIAN. Rivas GBS, et al. Curr Biol, 2021 Oct 11. PMID 34331859, Free PMC Article
    5. Clockwork Orange is a transcriptional repressor and a new Drosophila circadian pacemaker component. Kadener S, et al. Genes Dev, 2007 Jul 1. PMID 17578907, Free PMC Article

    See all (36) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables glycerophosphocholine phosphodiesterase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables myosin binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables phosphoric diester hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables starch binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in glycerophospholipid catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in lipid metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in sexual reproduction HEP PubMed 
    Component Evidence Code Pubs
    located_in extracellular space HDA PubMed 

    General protein information

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    Preferred Names
    uncharacterized protein
    Names
    CG18135-PA
    CG18135-PB
    CG18135-PC
    CG18135-PD
    CG18135-PE
    NP_001262028.1
    NP_649082.2
    NP_788524.1
    NP_788525.1
    NP_788526.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_037436.4 Reference assembly

      Range
      18990026..18998283 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_176346.2 → NP_788524.1  uncharacterized protein Dmel_CG18135, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_788524.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      C8VV56, Q9VVV6
      Related
      FBpp0074810
      Conserved Domains (3) summary
      cd05814
      Location:32 → 154
      CBM20_Prei4; Prei4, N-terminal CBM20 (carbohydrate-binding module, family 20) domain. Preimplantation protein 4 (Prei4) is a protein of unknown function that is expressed during mouse preimplantation embryogenesis. In addition to the N-terminal CBM20 domain, Prei4 ...
      cd08607
      Location:320 → 607
      GDPD_GDE5; Glycerophosphodiester phosphodiesterase domain of putative mammalian glycerophosphodiester phosphodiesterase GDE5 and similar proteins
      pfam03009
      Location:324 → 610
      GDPD; Glycerophosphoryl diester phosphodiesterase family

    2. NM_140825.3 → NP_649082.2  uncharacterized protein Dmel_CG18135, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_649082.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      C7LAE6, Q9VVV5
      Related
      FBpp0074809
      Conserved Domains (3) summary
      cd05814
      Location:49 → 171
      CBM20_Prei4; Prei4, N-terminal CBM20 (carbohydrate-binding module, family 20) domain. Preimplantation protein 4 (Prei4) is a protein of unknown function that is expressed during mouse preimplantation embryogenesis. In addition to the N-terminal CBM20 domain, Prei4 ...
      cd08607
      Location:337 → 624
      GDPD_GDE5; Glycerophosphodiester phosphodiesterase domain of putative mammalian glycerophosphodiester phosphodiesterase GDE5 and similar proteins
      pfam03009
      Location:341 → 627
      GDPD; Glycerophosphoryl diester phosphodiesterase family

    3. NM_176347.2 → NP_788525.1  uncharacterized protein Dmel_CG18135, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_788525.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      C8VV38, Q86BJ0
      Related
      FBpp0074811
      Conserved Domains (3) summary
      cd05814
      Location:107 → 229
      CBM20_Prei4; Prei4, N-terminal CBM20 (carbohydrate-binding module, family 20) domain. Preimplantation protein 4 (Prei4) is a protein of unknown function that is expressed during mouse preimplantation embryogenesis. In addition to the N-terminal CBM20 domain, Prei4 ...
      cd08607
      Location:395 → 682
      GDPD_GDE5; Glycerophosphodiester phosphodiesterase domain of putative mammalian glycerophosphodiester phosphodiesterase GDE5 and similar proteins
      pfam03009
      Location:399 → 685
      GDPD; Glycerophosphoryl diester phosphodiesterase family

    4. NM_176348.2 → NP_788526.1  uncharacterized protein Dmel_CG18135, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_788526.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      C8VV56, Q86BI9
      Related
      FBpp0074812
      Conserved Domains (3) summary
      cd05814
      Location:166 → 288
      CBM20_Prei4; Prei4, N-terminal CBM20 (carbohydrate-binding module, family 20) domain. Preimplantation protein 4 (Prei4) is a protein of unknown function that is expressed during mouse preimplantation embryogenesis. In addition to the N-terminal CBM20 domain, Prei4 ...
      cd08607
      Location:454 → 741
      GDPD_GDE5; Glycerophosphodiester phosphodiesterase domain of putative mammalian glycerophosphodiester phosphodiesterase GDE5 and similar proteins
      pfam03009
      Location:458 → 744
      GDPD; Glycerophosphoryl diester phosphodiesterase family

    5. NM_001275099.1 → NP_001262028.1  uncharacterized protein Dmel_CG18135, isoform E [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001262028.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      C8VV56, M9PI96
      Conserved Domains (3) summary
      cd05814
      Location:45 → 167
      CBM20_Prei4; Prei4, N-terminal CBM20 (carbohydrate-binding module, family 20) domain. Preimplantation protein 4 (Prei4) is a protein of unknown function that is expressed during mouse preimplantation embryogenesis. In addition to the N-terminal CBM20 domain, Prei4 ...
      cd08607
      Location:333 → 620
      GDPD_GDE5; Glycerophosphodiester phosphodiesterase domain of putative mammalian glycerophosphodiester phosphodiesterase GDE5 and similar proteins
      pfam03009
      Location:337 → 623
      GDPD; Glycerophosphoryl diester phosphodiesterase family
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    M9PI96 M9PI96
    Q86BI9 Q86BI9
    Q86BJ0 Q86BJ0
    Q9VVV5 Q9VVV5
    Q9VVV6 Q9VVV6

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