Lrrn3 leucine rich repeat neuronal 3 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Lrrn3provided by RGD
Official Full Name: leucine rich repeat neuronal 3provided by RGD
Primary source: RGD:71066
See related: EnsemblRapid:ENSRNOG00000006368 AllianceGenome:RGD:71066
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Nlrr3
Summary: Involved in positive regulation of protein phosphorylation. Part of clathrin adaptor complex. Orthologous to human LRRN3 (leucine rich repeat neuronal 3). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Brain (RPKM 201.3), Lung (RPKM 113.2) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 6q21

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	6	NC_086024.1 (64216164..64247293, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	6	NC_051341.1 (58489060..58520322, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	6	NC_005105.4 (61374328..61405195, complement)

Chromosome 6 - NC_086024.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

LRRN3 plays an important role in postnatal cerebellum development.
Title: [Role of LRRN3 in the cerebellum postnatal development in rats].
NLRR-3 potentiates Ras-MAPK signaling by facilitating internalization of EGF in clathrin-coated vesicles
Title: Neuronal leucine-rich repeat protein-3 amplifies MAPK activation by epidermal growth factor through a carboxyl-terminal region containing endocytosis motifs.
rNLRR-3 gene expression is regulated mainly through the Ras-MAPK signaling pathway in fibroblasts
Title: Rat neuronal leucine-rich repeat protein-3: cloning and regulation of the gene expression.

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General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables protein-containing complex binding	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in positive regulation of protein phosphorylation	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of synapse assembly	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within positive regulation of synapse assembly	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
part_of clathrin adaptor complex	IDA Inferred from Direct Assay more info	PubMed
is_active_in extracellular matrix	IBA Inferred from Biological aspect of Ancestor more info
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info
located_in membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: leucine-rich repeat neuronal protein 3

Names: NLRR-3; leucine rich repeat protein 3, neuronal; neuronal leucine-rich repeat protein 3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_030856.2 → NP_110483.2 leucine-rich repeat neuronal protein 3 precursor

Status: PROVISIONAL

Source sequence(s)

JAXUCZ010000006

UniProtKB/Swiss-Prot

Q642E4, Q9ESY6

UniProtKB/TrEMBL

A0A0G2JSI7, A6HBE1

Conserved Domains (8) summary

TIGR00864
Location:341 → 405

PCC; polycystin cation channel protein

smart00013
Location:28 → 72

LRRNT; Leucine rich repeat N-terminal domain

COG4886
Location:72 → 355

LRR; Leucine-rich repeat (LRR) protein [Transcription]

sd00031
Location:336 → 359

LRR_1; leucine-rich repeat [structural motif]

sd00033
Location:94 → 117

LRR_RI; leucine-rich repeat [structural motif]

pfam00041
Location:526 → 593

fn3; Fibronectin type III domain

cd00096
Location:440 → 447

Ig; Ig strand B [structural motif]

cl11960
Location:440 → 513

Ig; Immunoglobulin domain