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    Mnat1 MNAT1 component of CDK activating kinase [ Rattus norvegicus (Norway rat) ]

    Gene ID: 266713, updated on 14-Nov-2024

    Summary

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    Official Symbol
    Mnat1provided by RGD
    Official Full Name
    MNAT1 component of CDK activating kinaseprovided by RGD
    Primary source
    RGD:628874
    See related
    EnsemblRapid:ENSRNOG00000007267 AllianceGenome:RGD:628874
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable cyclin-dependent protein serine/threonine kinase activator activity and metal ion binding activity. Involved in G1/S transition of mitotic cell cycle; negative regulation of apoptotic process; and positive regulation of smooth muscle cell proliferation. Predicted to be located in chromosome; cytoplasm; and nucleus. Predicted to be part of CAK-ERCC2 complex; RNA polymerase II transcription regulator complex; and cyclin-dependent protein kinase holoenzyme complex. Orthologous to human MNAT1 (MNAT1 component of CDK activating kinase). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Muscle (RPKM 166.7), Thymus (RPKM 116.8) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Mnat1 in Genome Data Viewer
    Location:
    6q24
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 6 NC_086024.1 (97550566..97706598)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 6 NC_051341.1 (91814703..91971945)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 6 NC_005105.4 (95995341..96153331)

    Chromosome 6 - NC_086024.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC108351257 Neighboring gene SIX homeobox 1 Neighboring gene SIX homeobox 4 Neighboring gene small nucleolar RNA SNORA17 Neighboring gene Rab geranylgeranyltransferase subunit beta, pseudogene 1 Neighboring gene tRNA methyltransferase 5 Neighboring gene solute carrier family 38, member 6 Neighboring gene ribosomal protein L26, pseudogene 13 Neighboring gene ribosomal protein L26, pseudogene 4

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. RNA antisense abrogation of MAT1 induces G1 phase arrest and triggers apoptosis in aortic smooth muscle cells. Wu L, et al. J Biol Chem, 1999 Feb 26. PMID 10026172
    2. CDK7 and CCNH are components of CDK-activating kinase and are required for meiotic progression of pig oocytes. Fujii W, et al. Biol Reprod, 2011 Dec. PMID 21778139
    3. Distinct regions of MAT1 regulate cdk7 kinase and TFIIH transcription activities. Busso D, et al. J Biol Chem, 2000 Jul 28. PMID 10801852
    4. A history of TFIIH: two decades of molecular biology on a pivotal transcription/repair factor. Egly JM, et al. DNA Repair (Amst), 2011 Jul 15. PMID 21592869
    5. A yeast four-hybrid system identifies Cdk-activating kinase as a regulator of the XPD helicase, a subunit of transcription factor IIH. Sandrock B, et al. J Biol Chem, 2001 Sep 21. PMID 11445587

    See all (11) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables cyclin-dependent protein serine/threonine kinase activator activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in DNA repair IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in G1/S transition of mitotic cell cycle IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within adult heart development ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of apoptotic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in nucleotide-excision repair IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of smooth muscle cell proliferation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within regulation of DNA-templated transcription ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of G1/S transition of mitotic cell cycle ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within response to calcium ion ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in transcription initiation at RNA polymerase II promoter ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within ventricular system development ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    part_of CAK-ERCC2 complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in chromosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of cyclin-dependent protein kinase holoenzyme complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in germinal vesicle ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of transcription factor TFIIH core complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of transcription factor TFIIH holo complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of transcription factor TFIIH holo complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of transcription factor TFIIK complex ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    CDK-activating kinase assembly factor MAT1
    Names
    MNAT CDK-activating kinase assembly factor 1
    MNAT1, CDK activating kinase assembly factor
    menage a trois 1
    menage a trois homolog 1, cyclin H assembly factor

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_153472.2 → NP_703202.1  CDK-activating kinase assembly factor MAT1

      See identical proteins and their annotated locations for NP_703202.1

      Status: PROVISIONAL

      Source sequence(s)
      BC078712
      UniProtKB/TrEMBL
      A0A8I5ZYY1, A6HC54, Q6AZ68, Q8CIR5
      Conserved Domains (1) summary
      TIGR00570
      Location:1 → 308
      cdk7; CDK-activating kinase assembly factor MAT1

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086024.1 Reference GRCr8

      Range
      97550566..97706598
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063261569.1 → XP_063117639.1  CDK-activating kinase assembly factor MAT1 isoform X1

      UniProtKB/TrEMBL
      A0A8I5ZV40

    2. XM_063261570.1 → XP_063117640.1  CDK-activating kinase assembly factor MAT1 isoform X2

      UniProtKB/TrEMBL
      F7EX11
      Related
      ENSRNOP00000010163.4, ENSRNOT00000010163.7
    Nucleotide Protein Strain
    Heading Accession and Version

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