DIR1 Bifunctional inhibitor/lipid-transfer protein/seed storage 2S albumin superfamily protein [Arabidopsis thaliana (thale cress)] - Gene

Summary

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Official Symbol: DIR1
Official Full Name: Bifunctional inhibitor/lipid-transfer protein/seed storage 2S albumin superfamily protein
Primary source: TAIR:AT5G48485
Locus tag: AT5G48485
See related: Araport:AT5G48485
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Arabidopsis thaliana (ecotype: Columbia)
Lineage: Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as: DEFECTIVE IN INDUCED RESISTANCE 1
Summary: encodes a putative apoplastic lipid transfer protein that is involved in systemic acquired resistance. Mutants in this gene exhibit wild-type local resistance to avirulent and virulent Pseudomonas syringae, but pathogenesis-related gene expression is abolished in uninoculated distant leaves and fail to develop SAR to virulent Pseudomonas or Peronospora parasitica.
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Genomic context

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See DIR1 in Genome Data Viewer

Location:: chromosome: 5

Exon count:: 1

Sequence:: Chromosome: 5; NC_003076.8 (19646028..19646840, complement)

Chromosome 5 - NC_003076.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003076.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

cell-to-cell movement of DIR1 through plasmodesmata is important during long-distance systemic acquired resistance signalling in Arabidopsis.
Title: Plasmodesmata-located protein overexpression negatively impacts the manifestation of systemic acquired resistance and the long-distance movement of Defective in Induced Resistance1 in Arabidopsis.
The lipid transfer proteins DIR1 which is required for G3P- and azelaic acid-induced Systemic acquired resistance, is essential for G3P accumulation.
Title: A feedback regulatory loop between G3P and lipid transfer proteins DIR1 and AZI1 mediates azelaic-acid-induced systemic immunity.
DIR1 together with a glycerol-3-phosphate-derived compound are sufficient for the induction of systemic acquired resistance in wild type plants.
Title: Glycerol-3-phosphate and systemic immunity.
DIR1 contains a signal sequence that directs it to the cell wall, and is upregulated during the basal resistance response to Pseudomonas syringae.
Title: Localization of DIR1 at the tissue, cellular and subcellular levels during Systemic Acquired Resistance in Arabidopsis using DIR1:GUS and DIR1:EGFP reporters.
The structure of DIR1 reveals a new type of lipid transfer protein.
Title: The structure of "defective in induced resistance" protein of Arabidopsis thaliana, DIR1, reveals a new type of lipid transfer protein.
implicated in systemic acquired resistance in planta, and crystallized
Title: Crystallization of DIR1, a LTP2-like resistance signalling protein from Arabidopsis thaliana.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

NM_124224.3

Supported by ESTs:

Gene Ontology Provided by TAIR

Function	Evidence Code	Pubs
enables fatty acid binding	IDA Inferred from Direct Assay more info	PubMed
enables lipid transporter activity	ISS Inferred from Sequence or Structural Similarity more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables zinc ion binding	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of_or_within systemic acquired resistance	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in systemic acquired resistance, salicylic acid mediated signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in endoplasmic reticulum	IDA Inferred from Direct Assay more info	PubMed
located_in extracellular region	ISM Inferred from Sequence Model more info
located_in plasmodesma	IDA Inferred from Direct Assay more info	PubMed
located_in secretory vesicle	HDA more info	PubMed

General protein information

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Preferred Names: Bifunctional inhibitor/lipid-transfer protein/seed storage 2S albumin superfamily protein

NP_568699.1

DEFECTIVE IN INDUCED RESISTANCE 1 (DIR1); FUNCTIONS IN: lipid binding, lipid transporter activity; INVOLVED IN: systemic acquired resistance, lipid transport; LOCATED IN: endomembrane system; EXPRESSED IN: 22 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: Bifunctional inhibitor/plant lipid transfer protein/seed storage (InterPro:IPR016140), Plant lipid transfer protein/seed storage/trypsin-alpha amylase inhibitor (InterPro:IPR003612); BEST Arabidopsis thaliana protein match is: Bifunctional inhibitor/lipid-transfer protein/seed storage 2S albumin superfamily protein (TAIR:AT5G48490.1); Has 30201 Blast hits to 17322 proteins in 780 species: Archae - 12; Bacteria - 1396; Metazoa - 17338; Fungi - 3422; Plants - 5037; Viruses - 0; Other Eukaryotes - 2996 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003076.8 Reference assembly

Range

19646028..19646840 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_124224.3 → NP_568699.1 Bifunctional inhibitor/lipid-transfer protein/seed storage 2S albumin superfamily protein [Arabidopsis thaliana]

See identical proteins and their annotated locations for NP_568699.1

Status: REVIEWED

UniProtKB/Swiss-Prot

Q8LEU7, Q8W453

UniProtKB/TrEMBL

A0A178UC95, A0A5S9YD94, A0A654G949

Conserved Domains (1) summary

cd04660
Location:30 → 101

nsLTP_like; Non-specific lipid-transfer protein (nsLTP)-like subfamily; composed of predominantly uncharacterized proteins with similarity to nsLTPs, including Medicago truncatula MtN5, the root-specific Phaseolus vulgaris PVR3, Antirrhinum majus FIL1, and Lilium ...