Cd164 CD164 antigen [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Cd164provided by MGI
Official Full Name: CD164 antigenprovided by MGI
Primary source: MGI:MGI:1859568
See related: Ensembl:ENSMUSG00000019818 AllianceGenome:MGI:1859568
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: A24; A115; MSSP; MGC-24
Summary: Predicted to be involved in muscle organ development. Predicted to act upstream of or within heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules. Predicted to be located in plasma membrane. Predicted to be active in endosome and lysosome. Is expressed in several structures, including alimentary system; central nervous system; gonad; musculoskeletal system; and sensory organ. Human ortholog(s) of this gene implicated in autosomal dominant nonsyndromic deafness 66. Orthologous to human CD164 (CD164 molecule). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Ubiquitous expression in mammary gland adult (RPKM 103.9), placenta adult (RPKM 76.1) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 10 B2; 10 22.46 cM

Exon count:: 6

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	10	NC_000076.7 (41395496..41407038)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	10	NC_000076.6 (41519500..41531042)

Chromosome 10 - NC_000076.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

CD164 is a regulator of myoblast motility
Title: Regulation of myoblast motility and fusion by the CXCR4-associated sialomucin, CD164.
the deletion of the mssp gene results in both the growth defect in the embryo and the hormonal defect in adult female mouse.
Title: Disruption of MSSP, c-myc single-strand binding protein, leads to embryonic lethality in some homozygous mice.
MSSP is an important mediator for Fas-induced apoptosis in vivo and in vitro.
Title: Positive regulation of Fas gene expression by MSSP and abrogation of Fas-mediated apoptosis induction in MSSP-deficient mice.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (5)

General gene information

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Markers

RH125029 (e-PCR)
- UniSTS:161851

AW540279 (e-PCR)
- UniSTS:185828

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of_or_within cell adhesion	ISO Inferred from Sequence Orthology more info	PubMed
acts_upstream_of_or_within heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules	ISO Inferred from Sequence Orthology more info	PubMed
involved_in muscle organ development	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in endosome	IBA Inferred from Biological aspect of Ancestor more info
located_in endosome	ISO Inferred from Sequence Orthology more info
located_in endosome	ISS Inferred from Sequence or Structural Similarity more info
located_in endosome membrane	IEA Inferred from Electronic Annotation more info
located_in lysosomal membrane	IEA Inferred from Electronic Annotation more info
is_active_in lysosome	IBA Inferred from Biological aspect of Ancestor more info
located_in lysosome	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info	PubMed
located_in plasma membrane	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: sialomucin core protein 24

Names: MGC-24v; MUC-24; c-Myc binding protein; endolyn; multi-glycosylated core protein 24

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.