Adra2b adrenergic receptor, alpha 2b [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Adra2bprovided by MGI
Official Full Name: adrenergic receptor, alpha 2bprovided by MGI
Primary source: MGI:MGI:87935
See related: Ensembl:ENSMUSG00000058620 AllianceGenome:MGI:87935
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: [a]2B; a2b-AR; Adra-2b; alpha2B; alpha2-C2
Summary: Enables alpha2-adrenergic receptor activity. Acts upstream of or within G protein-coupled receptor signaling pathway; MAPK cascade; and angiogenesis. Predicted to be located in cell surface; cytosol; and intracellular membrane-bounded organelle. Predicted to be active in plasma membrane. Is expressed in several structures, including adrenal gland; central nervous system; liver; and retina. Human ortholog(s) of this gene implicated in diabetic neuropathy; hypertension; myocardial infarction; obesity; and type 2 diabetes mellitus. Orthologous to human ADRA2B (adrenoceptor alpha 2B). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs: human all
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Genomic context

Location:: 2 F1; 2 61.95 cM

Exon count:: 1

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	2	NC_000068.8 (127205099..127209141)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	2	NC_000068.7 (127363179..127367221)

Chromosome 2 - NC_000068.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

alpha2B KO mice exhibit altered locomotor behaviors and compulsive burying behavior, are acutely sensitive to the stereotypy effects of the psychostimulant amphetamine; an identical tendency in alpha2C KO mice administered the alpha2B-receptor-selective antagonist AGN-209419 with amphetamine. Findings suggest a compulsive phenotype for alpha2B KO mice, and a broader role for the alpha2B receptor.
Title: Function of brain α(2B)-adrenergic receptor characterized with subtype-selective α(2B) antagonist and KO mice.
Data indicate that In arrestin 3 deficient mice, where the alpha2B adrenergic receptor has a stronger binding to spinophilin, the hypertensive response is enhanced.
Title: Spinophilin Is Indispensable for the α2B Adrenergic Receptor-Elicited Hypertensive Response.
Activation of the adenosine A(2B) receptor protects against vascular injury, while it also enhances plaque stability as indicated by increased collagen content.
Title: Adenosine A₂B receptor agonism inhibits neointimal lesion development after arterial injury in apolipoprotein E-deficient mice.
Demonstrate that both A(2A)ARs and A(2B)ARs induce coronary flow changes through K(ATP) channels.
Title: Contributions of A2A and A2B adenosine receptors in coronary flow responses in relation to the KATP channel using A2B and A2A/2B double-knockout mice.
alpha(2B)-adrenoceptors in lung epithelia play an important role in suppressing sonic hedgehog-mediated proliferation of mesenchymal cells and thus prevent respiratory failure
Title: {Alpha}2B-adrenoceptor deficiency leads to postnatal respiratory failure in mice.
Overexpression of the alpha(2B)-AR gene leads to increased production of alpha(2B)-AR protein in brain regions known to regulate central sympathetic outflow, thus resulting in sustained BP elevation.
Title: Hypertension in transgenic mice with brain-selective overexpression of the alpha(2B)-adrenoceptor.
alpha2B adrenoceptor deficient mice develop a defect in fetal and maternal vessel formation in the placenta.
Title: Upregulation of soluble vascular endothelial growth factor receptor 1 contributes to angiogenesis defects in the placenta of alpha 2B-adrenoceptor deficient mice.
Loss of Adra2b increases magnitude of hypertension following nitric oxide synthase inhibition.
Title: Loss of alpha2B-adrenoceptors increases magnitude of hypertension following nitric oxide synthase inhibition.
by blocking G protein receptor kinase 2 association with receptor-Gbetagamma complexes, spinophilin reduces arrestin- stabilized receptor phosphorylation, receptor endocytosis & acceleration of mitogen-activated protein kinase activity after endocytosis
Title: Spinophilin blocks arrestin actions in vitro and in vivo at G protein-coupled receptors.
alpha2B adrenoceptor regulated expression is examined in mouse brain development
Title: Regulated expression of alpha2B adrenoceptor during development.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (5)
Targeted (1) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables adrenergic receptor activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables alpha2-adrenergic receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables alpha2-adrenergic receptor activity	IDA Inferred from Direct Assay more info	PubMed
enables alpha2-adrenergic receptor activity	ISO Inferred from Sequence Orthology more info
enables epinephrine binding	IBA Inferred from Biological aspect of Ancestor more info
enables epinephrine binding	IEA Inferred from Electronic Annotation more info
enables epinephrine binding	ISO Inferred from Sequence Orthology more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of_or_within G protein-coupled receptor signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in G protein-coupled receptor signaling pathway	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within MAPK cascade	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in activation of protein kinase B activity	ISO Inferred from Sequence Orthology more info
involved_in adrenergic receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in adrenergic receptor signaling pathway	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within angiogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in female pregnancy	IEA Inferred from Electronic Annotation more info
involved_in female pregnancy	ISO Inferred from Sequence Orthology more info
involved_in platelet activation	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of MAPK cascade	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of MAPK cascade	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of blood pressure	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of blood pressure	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of neuron differentiation	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of neuron differentiation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of uterine smooth muscle contraction	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of uterine smooth muscle contraction	ISO Inferred from Sequence Orthology more info
involved_in receptor transactivation	ISO Inferred from Sequence Orthology more info
involved_in regulation of vascular associated smooth muscle contraction	IEA Inferred from Electronic Annotation more info
involved_in regulation of vascular associated smooth muscle contraction	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in cell surface	ISO Inferred from Sequence Orthology more info
located_in cell surface	ISS Inferred from Sequence or Structural Similarity more info
located_in cytosol	IEA Inferred from Electronic Annotation more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in intracellular membrane-bounded organelle	IEA Inferred from Electronic Annotation more info
located_in intracellular membrane-bounded organelle	ISO Inferred from Sequence Orthology more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: alpha-2B adrenergic receptor

Names: alpha-2B adrenoceptor; alpha-2B adrenoreceptor; alpha-2BAR; subtype alpha2-C2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_009633.4 → NP_033763.3 alpha-2B adrenergic receptor

Status: VALIDATED

Source sequence(s)

AL731836

Consensus CDS

CCDS16701.2

UniProtKB/TrEMBL

Q925K6, Q925K7

Related

ENSMUSP00000100539.2, ENSMUST00000104934.2

Conserved Domains (2) summary

PRK12323
Location:209 → 354

PRK12323; DNA polymerase III subunits gamma and tau; Provisional

cd15321
Location:7 → 435

7tmA_alpha2B_AR; alpha-2 adrenergic receptors subtype B, member of the class A family of seven-transmembrane G protein-coupled receptors