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    Fhip1b FHF complex subunit HOOK interacting protein 1B [ Mus musculus (house mouse) ]

    Gene ID: 74349, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Fhip1bprovided by MGI
    Official Full Name
    FHF complex subunit HOOK interacting protein 1Bprovided by MGI
    Primary source
    MGI:MGI:1921599
    See related
    Ensembl:ENSMUSG00000044465 AllianceGenome:MGI:1921599
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    FHIP; Fam160a2; 4632419K20Rik; 6530415H11Rik
    Summary
    Predicted to be involved in several processes, including early endosome to late endosome transport; endosome to lysosome transport; and protein localization to perinuclear region of cytoplasm. Predicted to be part of FHF complex. Orthologous to human FHIP1B (FHF complex subunit HOOK interacting protein 1B). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in testis adult (RPKM 14.1), colon adult (RPKM 9.4) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Fhip1b in Genome Data Viewer
    Location:
    7 E3; 7 55.84 cM
    Exon count:
    16
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (105020418..105049349, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (105371211..105400142, complement)

    Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene olfactory receptor family 52 subfamily B member 2 Neighboring gene olfactory receptor family 52 subfamily W member 1 Neighboring gene predicted gene 5901 Neighboring gene STARR-positive B cell enhancer ABC_E4960 Neighboring gene STARR-positive B cell enhancer ABC_E3739 Neighboring gene cyclic nucleotide gated channel alpha 4 Neighboring gene predicted gene 4972 Neighboring gene cholecystokinin B receptor

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Interactome of vertebrate GAF/ThPOK reveals its diverse functions in gene regulation and DNA repair. Srivastava A, et al. J Biosci, 2020. PMID 32098917
    2. Prediction of the coding sequences of mouse homologues of KIAA gene: II. The complete nucleotide sequences of 400 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries. Okazaki N, et al. DNA Res, 2003 Feb 28. PMID 12693553
    3. BioID screening of biotinylation sites using the avidin-like protein Tamavidin 2-REV identifies global interactors of stimulator of interferon genes (STING). Motani K, et al. J Biol Chem, 2020 Aug 7. PMID 32554809, Free PMC Article
    4. The Vertebrate Genome Annotation browser 10 years on. Harrow JL, et al. Nucleic Acids Res, 2014 Jan. PMID 24316575, Free PMC Article
    5. EUCOMM--the European conditional mouse mutagenesis program. Friedel RH, et al. Brief Funct Genomic Proteomic, 2007 Sep. PMID 17967808

    See all (22) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in early endosome to late endosome transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in early endosome to late endosome transport ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in early endosome to late endosome transport ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in endosome organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in endosome organization ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in endosome organization ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in endosome to lysosome transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in endosome to lysosome transport ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in endosome to lysosome transport ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in lysosome organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in lysosome organization ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in lysosome organization ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in protein localization to perinuclear region of cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein localization to perinuclear region of cytoplasm ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in protein transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    part_of FHF complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of FHF complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of FHF complex ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    FHF complex subunit HOOK-interacting protein 1B
    Names
    FTS and Hook-interacting protein
    family with sequence similarity 160, member A2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001242363.2 → NP_001229292.1  FHF complex subunit HOOK-interacting protein 1B isoform a

      See identical proteins and their annotated locations for NP_001229292.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript. Variants 1 and 2 encode the same isoform (a).
      Source sequence(s)
      AC125055, AK085350, AK159716, BY309982, CJ102928
      Consensus CDS
      CCDS21649.1
      UniProtKB/Swiss-Prot
      Q3TWF5, Q3U2I3, Q6P543, Q80T93, Q811J6, Q8BI34, Q8VE55
      UniProtKB/TrEMBL
      F8WHJ1
      Related
      ENSMUSP00000112711.2, ENSMUST00000122327.7
      Conserved Domains (2) summary
      PHA03321
      Location:459 → 585
      PHA03321; tegument protein VP11/12; Provisional
      pfam10257
      Location:97 → 426
      RAI16-like; Retinoic acid induced 16-like protein

    2. NM_001242364.2 → NP_001229293.1  FHF complex subunit HOOK-interacting protein 1B isoform b

      See identical proteins and their annotated locations for NP_001229293.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR and uses an alternate in-frame splice junction at the 3' end of an exon compared to variant 1. The resulting isoform (b) is the longest isoform and contains an alternate internal segment compared to isoform a.
      Source sequence(s)
      AC125055, AK085350, AK159716, BE861154, BY309982
      Consensus CDS
      CCDS57574.1
      UniProtKB/TrEMBL
      A0A1C7CYU5, F8WHJ1
      Related
      ENSMUSP00000045084.8, ENSMUST00000048079.14
      Conserved Domains (1) summary
      pfam10257
      Location:97 → 426
      RAI16-like; Retinoic acid induced 16-like protein

    3. NM_001242365.2 → NP_001229294.1  FHF complex subunit HOOK-interacting protein 1B isoform c

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) differs in the 5' UTR and has alternate in-frame splice junctions at the 3' ends of two exons compared to variant 1. The resulting isoform (c) contains an alternate internal segment and lacks another alternate internal segment compared to isoform a.
      Source sequence(s)
      AC125055, AK159716, BY309982
      Consensus CDS
      CCDS57575.1
      UniProtKB/TrEMBL
      F8WHJ1
      Related
      ENSMUSP00000112605.2, ENSMUST00000118726.8
      Conserved Domains (1) summary
      pfam10257
      Location:97 → 426
      RAI16-like; Retinoic acid induced 16-like protein

    4. NM_199009.3 → NP_950174.1  FHF complex subunit HOOK-interacting protein 1B isoform a

      See identical proteins and their annotated locations for NP_950174.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1 and 2 encode the same isoform (a).
      Source sequence(s)
      AC125055, BC063093, BY309982
      Consensus CDS
      CCDS21649.1
      UniProtKB/Swiss-Prot
      Q3TWF5, Q3U2I3, Q6P543, Q80T93, Q811J6, Q8BI34, Q8VE55
      UniProtKB/TrEMBL
      F8WHJ1
      Related
      ENSMUSP00000137163.3, ENSMUST00000179474.9
      Conserved Domains (2) summary
      PHA03321
      Location:459 → 585
      PHA03321; tegument protein VP11/12; Provisional
      pfam10257
      Location:97 → 426
      RAI16-like; Retinoic acid induced 16-like protein

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000073.7 Reference GRCm39 C57BL/6J

      Range
      105020418..105049349 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_030243034.1 → XP_030098894.1  FHF complex subunit HOOK-interacting protein 1B isoform X1

      UniProtKB/TrEMBL
      A0A1C7CYU5, F8WHJ1
      Conserved Domains (1) summary
      pfam10257
      Location:97 → 426
      RAI16-like; Retinoic acid induced 16-like protein

    2. XM_030243035.2 → XP_030098895.1  FHF complex subunit HOOK-interacting protein 1B isoform X3

      UniProtKB/TrEMBL
      F8WHJ1
      Conserved Domains (1) summary
      pfam10257
      Location:97 → 426
      RAI16-like; Retinoic acid induced 16-like protein

    3. XM_006508251.5 → XP_006508314.1  FHF complex subunit HOOK-interacting protein 1B isoform X1

      See identical proteins and their annotated locations for XP_006508314.1

      UniProtKB/TrEMBL
      A0A1C7CYU5, F8WHJ1
      Conserved Domains (1) summary
      pfam10257
      Location:97 → 426
      RAI16-like; Retinoic acid induced 16-like protein

    4. XM_030243038.2 → XP_030098898.1  FHF complex subunit HOOK-interacting protein 1B isoform X5

    5. XM_036153501.1 → XP_036009394.1  FHF complex subunit HOOK-interacting protein 1B isoform X4

    6. XM_030243033.2 → XP_030098893.1  FHF complex subunit HOOK-interacting protein 1B isoform X1

      UniProtKB/TrEMBL
      A0A1C7CYU5, F8WHJ1
      Conserved Domains (1) summary
      pfam10257
      Location:97 → 426
      RAI16-like; Retinoic acid induced 16-like protein

    7. XM_036153500.1 → XP_036009393.1  FHF complex subunit HOOK-interacting protein 1B isoform X2

      UniProtKB/Swiss-Prot
      Q3TWF5, Q3U2I3, Q6P543, Q80T93, Q811J6, Q8BI34, Q8VE55
      UniProtKB/TrEMBL
      F8WHJ1
      Conserved Domains (2) summary
      PHA03321
      Location:459 → 585
      PHA03321; tegument protein VP11/12; Provisional
      pfam10257
      Location:97 → 426
      RAI16-like; Retinoic acid induced 16-like protein

    8. XM_030243036.2 → XP_030098896.1  FHF complex subunit HOOK-interacting protein 1B isoform X4

    9. XM_030243037.2 → XP_030098897.1  FHF complex subunit HOOK-interacting protein 1B isoform X4

    10. XM_030243032.2 → XP_030098892.1  FHF complex subunit HOOK-interacting protein 1B isoform X1

      UniProtKB/TrEMBL
      A0A1C7CYU5, F8WHJ1
      Conserved Domains (1) summary
      pfam10257
      Location:97 → 426
      RAI16-like; Retinoic acid induced 16-like protein

    11. XM_036153499.1 → XP_036009392.1  FHF complex subunit HOOK-interacting protein 1B isoform X1

      UniProtKB/TrEMBL
      A0A1C7CYU5, F8WHJ1
      Conserved Domains (1) summary
      pfam10257
      Location:97 → 426
      RAI16-like; Retinoic acid induced 16-like protein

    RNA

    1. XR_001778008.3 RNA Sequence

    2. XR_003946573.2 RNA Sequence

    3. XR_378277.4 RNA Sequence

    4. XR_004934198.1 RNA Sequence

    5. XR_004934196.1 RNA Sequence

    6. XR_004934197.1 RNA Sequence

    7. XR_004934195.1 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q3U2I3.2 GenPept UniProtKB/Swiss-Prot:Q3U2I3

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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