Car7 carbonic anhydrase 7 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Car7provided by MGI
Official Full Name: carbonic anhydrase 7provided by MGI
Primary source: MGI:MGI:103100
See related: Ensembl:ENSMUSG00000031883 AllianceGenome:MGI:103100
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Ca7
Summary: Enables carbonate dehydratase activity. Acts upstream of or within several processes, including positive regulation of GABAergic synaptic transmission; positive regulation of cellular pH reduction; and regulation of chloride transport. Located in cytosol. Is expressed in several structures, including brain; genitourinary system; inner ear; liver; and trunk. Orthologous to human CA7 (carbonic anhydrase 7). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Broad expression in cerebellum adult (RPKM 10.1), cortex adult (RPKM 7.5) and 19 other tissues See more
Orthologs: human all
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Genomic context

Location:: 8 D3; 8 53.04 cM

Exon count:: 14

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	8	NC_000074.7 (105261326..105276979)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	8	NC_000074.6 (104534694..104550347)

Chromosome 8 - NC_000074.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Neuronal carbonic anhydrase VII provides GABAergic excitatory drive to exacerbate febrile seizures.
Title: Neuronal carbonic anhydrase VII provides GABAergic excitatory drive to exacerbate febrile seizures.
Car2, Car3, Car7, and Car15 mRNAs were barely within the detection limits in the mouse harderian gland.
Title: Carbonic anhydrases in the mouse harderian gland.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (2)
Targeted (3) 1 citation

General gene information

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Markers

AV343731 (e-PCR)
- UniSTS:179797

Car7 (e-PCR), detects polymorphism
- UniSTS:506777

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables carbonate dehydratase activity	IBA Inferred from Biological aspect of Ancestor more info
enables carbonate dehydratase activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables zinc ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within neuron cellular homeostasis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within positive regulation of cellular pH reduction	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within positive regulation of synaptic transmission, GABAergic	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within regulation of chloride transport	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of intracellular pH	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytosol	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: carbonic anhydrase 7

Names: CA-VII; carbonate dehydratase VII; carbonic anhydrase VII

NP_001288093.1

EC 4.2.1.1

NP_001288094.1

EC 4.2.1.1

NP_001403595.1

EC 4.2.1.1

NP_444300.1

EC 4.2.1.1

XP_006530680.1

EC 4.2.1.1

XP_006530681.1

EC 4.2.1.1

XP_030099123.1

EC 4.2.1.1

XP_036009627.1

EC 4.2.1.1

XP_036009628.1

EC 4.2.1.1

XP_036009629.1

EC 4.2.1.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001301164.1 → NP_001288093.1 carbonic anhydrase 7 isoform b

See identical proteins and their annotated locations for NP_001288093.1

Status: VALIDATED

Description

Transcript Variant: This variant (2) has an alternate first exon and uses a downstream translation start site compared to variant 1. The resulting isoform (b) is shorter at the N-terminus compared to isoform a. Variants 2 and 3 both encode the same isoform (b).

Source sequence(s)

AC130543, BC094913, BY741075

Consensus CDS

CCDS80920.1

UniProtKB/TrEMBL

G3XA26, Q3UND9

Related

ENSMUSP00000125112.2, ENSMUST00000159416.8

Conserved Domains (1) summary

cl00012
Location:1 → 206

alpha_CA; Carbonic anhydrase alpha (vertebrate-like) group. Carbonic anhydrases (CAs) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism: a nucleophilic attack of a zinc-bound hydroxide ion on carbon ...
NM_001301165.1 → NP_001288094.1 carbonic anhydrase 7 isoform b

See identical proteins and their annotated locations for NP_001288094.1

Status: VALIDATED

Description

Transcript Variant: This variant (3) has an alternate first exon and uses a downstream translation start site compared to variant 1. The resulting isoform (b) is shorter at the N-terminus compared to isoform a. Variants 2 and 3 both encode the same isoform (b).

Source sequence(s)

AC130543, AK144275, BC094913

Consensus CDS

CCDS80920.1

UniProtKB/TrEMBL

G3XA26, Q3UND9

Related

ENSMUSP00000125404.2, ENSMUST00000162761.2

Conserved Domains (1) summary

cl00012
Location:1 → 206

alpha_CA; Carbonic anhydrase alpha (vertebrate-like) group. Carbonic anhydrases (CAs) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism: a nucleophilic attack of a zinc-bound hydroxide ion on carbon ...
NM_001416666.1 → NP_001403595.1 carbonic anhydrase 7 isoform b

Status: VALIDATED

Source sequence(s)

AC130543

UniProtKB/TrEMBL

G3XA26
NM_053070.3 → NP_444300.1 carbonic anhydrase 7 isoform a

See identical proteins and their annotated locations for NP_444300.1

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longer isoform (a).

Source sequence(s)

AC130543

Consensus CDS

CCDS22581.1

UniProtKB/Swiss-Prot

Q811X4, Q9ERQ8

Related

ENSMUSP00000052136.5, ENSMUST00000056051.11

Conserved Domains (1) summary

cd03149
Location:27 → 262

alpha_CA_VII; Carbonic anhydrase alpha, CA isozyme VII_like subgroup. Carbonic anhydrases (CAs) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism: a nucleophilic attack of a zinc-bound hydroxide ion on carbon ...

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000074.7 Reference GRCm39 C57BL/6J

Range

105261326..105276979

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_036153734.1 → XP_036009627.1 carbonic anhydrase 7 isoform X2

UniProtKB/TrEMBL

Q3UND9

Conserved Domains (1) summary

cl00012
Location:50 → 232

alpha_CA; Carbonic anhydrase alpha (vertebrate-like) group. Carbonic anhydrases (CAs) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism: a nucleophilic attack of a zinc-bound hydroxide ion on carbon ...
XM_030243263.2 → XP_030099123.1 carbonic anhydrase 7 isoform X1

Conserved Domains (1) summary

cl00012
Location:70 → 252

alpha_CA; Carbonic anhydrase alpha (vertebrate-like) group. Carbonic anhydrases (CAs) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism: a nucleophilic attack of a zinc-bound hydroxide ion on carbon ...
XM_036153735.1 → XP_036009628.1 carbonic anhydrase 7 isoform X4

Conserved Domains (1) summary

cl00012
Location:2 → 158

alpha_CA; Carbonic anhydrase alpha (vertebrate-like) group. Carbonic anhydrases (CAs) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism: a nucleophilic attack of a zinc-bound hydroxide ion on carbon ...
XM_036153736.1 → XP_036009629.1 carbonic anhydrase 7 isoform X4

Conserved Domains (1) summary

cl00012
Location:2 → 158

alpha_CA; Carbonic anhydrase alpha (vertebrate-like) group. Carbonic anhydrases (CAs) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism: a nucleophilic attack of a zinc-bound hydroxide ion on carbon ...
XM_006530617.4 → XP_006530680.1 carbonic anhydrase 7 isoform X3

See identical proteins and their annotated locations for XP_006530680.1

UniProtKB/TrEMBL

G3XA26, Q3UND9

Conserved Domains (1) summary

cl00012
Location:1 → 206

alpha_CA; Carbonic anhydrase alpha (vertebrate-like) group. Carbonic anhydrases (CAs) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism: a nucleophilic attack of a zinc-bound hydroxide ion on carbon ...
XM_006530618.4 → XP_006530681.1 carbonic anhydrase 7 isoform X3

See identical proteins and their annotated locations for XP_006530681.1

UniProtKB/TrEMBL

G3XA26, Q3UND9

Conserved Domains (1) summary

cl00012
Location:1 → 206

alpha_CA; Carbonic anhydrase alpha (vertebrate-like) group. Carbonic anhydrases (CAs) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism: a nucleophilic attack of a zinc-bound hydroxide ion on carbon ...