Strn4 striatin, calmodulin binding protein 4 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Strn4provided by MGI
Official Full Name: striatin, calmodulin binding protein 4provided by MGI
Primary source: MGI:MGI:2142346
See related: Ensembl:ENSMUSG00000030374 AllianceGenome:MGI:2142346
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: ZIN; zinedin
Summary: Predicted to enable several functions, including armadillo repeat domain binding activity; calmodulin binding activity; and protein phosphatase 2A binding activity. Predicted to be involved in negative regulation of hippo signaling. Predicted to be located in dendritic spine. Predicted to be part of FAR/SIN/STRIPAK complex. Predicted to be active in dendrite. Is expressed in several structures, including alimentary system; brain; genitourinary system; hemolymphoid system; and musculoskeletal system. Orthologous to human STRN4 (striatin 4). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Ubiquitous expression in whole brain E14.5 (RPKM 50.8), CNS E18 (RPKM 43.7) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 7 A2; 7 9.15 cM

Exon count:: 19

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	7	NC_000073.7 (16549814..16574856)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	7	NC_000073.6 (16815889..16840931)

Chromosome 7 - NC_000073.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (3)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

09.MMHAP70FLC3.seq (e-PCR)
- UniSTS:122992

RH126951 (e-PCR)
- UniSTS:208072

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables armadillo repeat domain binding	IEA Inferred from Electronic Annotation more info
enables armadillo repeat domain binding	ISO Inferred from Sequence Orthology more info
enables calmodulin binding	IBA Inferred from Biological aspect of Ancestor more info
enables calmodulin binding	IEA Inferred from Electronic Annotation more info
enables molecular_function	ND No biological Data available more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein domain specific binding	ISO Inferred from Sequence Orthology more info
enables protein phosphatase 2A binding	IBA Inferred from Biological aspect of Ancestor more info
enables protein phosphatase 2A binding	IEA Inferred from Electronic Annotation more info
enables protein phosphatase 2A binding	ISO Inferred from Sequence Orthology more info
enables protein-containing complex binding	IBA Inferred from Biological aspect of Ancestor more info
enables protein-containing complex binding	IEA Inferred from Electronic Annotation more info
enables protein-containing complex binding	ISO Inferred from Sequence Orthology more info
enables protein-macromolecule adaptor activity	ISO Inferred from Sequence Orthology more info
enables protein-macromolecule adaptor activity	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
involved_in biological_process	ND No biological Data available more info
involved_in negative regulation of hippo signaling	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of hippo signaling	ISO Inferred from Sequence Orthology more info
involved_in regulation of modification of postsynaptic structure	IEA Inferred from Electronic Annotation more info
involved_in regulation of signal transduction	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
part_of FAR/SIN/STRIPAK complex	IBA Inferred from Biological aspect of Ancestor more info
part_of FAR/SIN/STRIPAK complex	ISO Inferred from Sequence Orthology more info
part_of FAR/SIN/STRIPAK complex	ISS Inferred from Sequence or Structural Similarity more info
located_in GABA-ergic synapse	IEA Inferred from Electronic Annotation more info
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
is_active_in dendrite	IBA Inferred from Biological aspect of Ancestor more info
located_in dendritic spine	IEA Inferred from Electronic Annotation more info
located_in dendritic spine	ISO Inferred from Sequence Orthology more info
located_in glutamatergic synapse	IEA Inferred from Electronic Annotation more info
located_in membrane	IEA Inferred from Electronic Annotation more info
part_of protein-containing complex	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: striatin-4

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001039878.2 → NP_001034967.1 striatin-4 isoform 2

Status: VALIDATED

Description

Transcript Variant: This variant (2) uses an alternate splice site in the central coding region, compared to variant 1. The resulting isoform (2) lacks an internal 7-aa segment, compared to isoform 1.

Source sequence(s)

AC148981, AK136155, BC066805

Consensus CDS

CCDS39787.1

UniProtKB/TrEMBL

Q3U3S0

Related

ENSMUSP00000104135.2, ENSMUST00000108495.9

Conserved Domains (4) summary

COG2319
Location:416 → 746

WD40; WD40 repeat [General function prediction only]

cd00200
Location:430 → 752

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

pfam08232
Location:64 → 189

Striatin; Striatin family

sd00039
Location:443 → 489

7WD40; WD40 repeat [structural motif]
NM_133789.3 → NP_598550.2 striatin-4 isoform 1

See identical proteins and their annotated locations for NP_598550.2

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).

Source sequence(s)

AC148981, BC066805, BC080283

Consensus CDS

CCDS39786.1

UniProtKB/Swiss-Prot

E9QKX6, P58404, Q68EF5

UniProtKB/TrEMBL

Q3U3S0

Related

ENSMUSP00000019220.9, ENSMUST00000019220.16

Conserved Domains (4) summary

COG2319
Location:423 → 753

WD40; WD40 repeat [General function prediction only]

cd00200
Location:437 → 759

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

pfam08232
Location:64 → 189

Striatin; Striatin family

sd00039
Location:450 → 496

7WD40; WD40 repeat [structural motif]

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000073.7 Reference GRCm39 C57BL/6J

Range

16549814..16574856

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_017312409.2 → XP_017167898.1 striatin-4 isoform X3

Conserved Domains (1) summary

pfam08232
Location:64 → 189

Striatin; Striatin family
XM_036153606.1 → XP_036009499.1 striatin-4 isoform X4

Conserved Domains (1) summary

pfam08232
Location:65 → 189

Striatin; Striatin family
XM_006540446.3 → XP_006540509.1 striatin-4 isoform X1

UniProtKB/TrEMBL

Q3U3S0

Conserved Domains (3) summary

cd00200
Location:318 → 640

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

sd00039
Location:331 → 377

7WD40; WD40 repeat [structural motif]

pfam08232
Location:1 → 70

Striatin; Striatin family
XM_017312408.2 → XP_017167897.1 striatin-4 isoform X2

UniProtKB/TrEMBL

Q3U3S0

Conserved Domains (3) summary

cd00200
Location:311 → 633

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

sd00039
Location:324 → 370

7WD40; WD40 repeat [structural motif]

pfam08232
Location:1 → 70

Striatin; Striatin family