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    Zdhhc21 zinc finger, DHHC domain containing 21 [ Mus musculus (house mouse) ]

    Gene ID: 68268, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Zdhhc21provided by MGI
    Official Full Name
    zinc finger, DHHC domain containing 21provided by MGI
    Primary source
    MGI:MGI:1915518
    See related
    Ensembl:ENSMUSG00000028403 AllianceGenome:MGI:1915518
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    dep; DHHC21; 9130404H11Rik; D130004H04Rik
    Summary
    Enables protein-cysteine S-palmitoyltransferase activity. Involved in several processes, including peptidyl-L-cysteine S-palmitoylation; regulation of establishment of endothelial barrier; and regulation of vascular associated smooth muscle contraction. Acts upstream of or within hair follicle development; protein palmitoylation; and sebaceous gland development. Predicted to be located in plasma membrane. Predicted to be active in Golgi apparatus and endoplasmic reticulum. Is expressed in early conceptus; eye; inner cell mass; oocyte; and trunk somite. Orthologous to human ZDHHC21 (zinc finger DHHC-type palmitoyltransferase 21). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in placenta adult (RPKM 3.3), CNS E18 (RPKM 3.0) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Zdhhc21 in Genome Data Viewer
    Location:
    4 39.4 cM; 4 C3
    Exon count:
    16
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (82716975..82778892, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (82798738..82859897, complement)

    Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene nuclear encoded tRNA histidine 10 (anticodon GTG) Neighboring gene predicted gene 11269 Neighboring gene STARR-seq mESC enhancer starr_10625 Neighboring gene STARR-seq mESC enhancer starr_10626 Neighboring gene VISTA enhancer mm56 Neighboring gene cerberus 1, DAN family BMP antagonist Neighboring gene Fras1 related extracellular matrix protein 1 Neighboring gene predicted gene, 33260

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. DHHC21 deficiency attenuates renal dysfunction during septic injury. Yang X, et al. Sci Rep, 2021 May 27. PMID 34045489, Free PMC Article
    2. Regulation of T cell receptor signaling by protein acyltransferase DHHC21. Fan Y, et al. Mol Biol Rep, 2020 Aug. PMID 32789573, Free PMC Article
    3. Ca2+-dependent protein acyltransferase DHHC21 controls activation of CD4+ T cells. Bieerkehazhi S, et al. J Cell Sci, 2022 Mar 1. PMID 34080635, Free PMC Article
    4. Targeting palmitoyl acyltransferase ZDHHC21 improves gut epithelial barrier dysfunction resulting from burn-induced systemic inflammation. Haines RJ, et al. Am J Physiol Gastrointest Liver Physiol, 2017 Dec 1. PMID 28838985, Free PMC Article
    5. The Protein Acyl Transferase ZDHHC21 Modulates α1 Adrenergic Receptor Function and Regulates Hemodynamics. Marin EP, et al. Arterioscler Thromb Vasc Biol, 2016 Feb. PMID 26715683, Free PMC Article

    See all (36) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. DHHC21 deficiency attenuates renal dysfunction during septic injury.
      Title: DHHC21 deficiency attenuates renal dysfunction during septic injury.
    2. Ca2+-dependent protein acyltransferase DHHC21 controls activation of CD4+ T cells.
      Title: Ca2+-dependent protein acyltransferase DHHC21 controls activation of CD4+ T cells.
    3. Regulation of T cell receptor signaling by protein acyltransferase DHHC21.
      Title: Regulation of T cell receptor signaling by protein acyltransferase DHHC21.
    4. Results suggest an important role of ZDHHC21 in mediating gut hyperpermeability resulting from thermal injury.
      Title: Targeting palmitoyl acyltransferase ZDHHC21 improves gut epithelial barrier dysfunction resulting from burn-induced systemic inflammation.
    5. ZDHHC21 F233Delta diminishes the function of vascular alpha1 adrenergic receptors, leading to reduced vascular tone, which manifests in vivo as hypotension and tachycardia.
      Title: The Protein Acyl Transferase ZDHHC21 Modulates α1 Adrenergic Receptor Function and Regulates Hemodynamics.
    6. the Src-family kinase, Fyn, involved in keratinocyte differentiation, is a direct palmitoylation target of Zdhhc21 and is mislocalized in mutant follicles
      Title: Palmitoylation regulates epidermal homeostasis and hair follicle differentiation.
    Submit: New GeneRIF Correction

    Phenotypes

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    Associated conditions

    Description Tests
    depilated
    GeneReviews: Not available

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (4) 
    • Spontaneous (1) 

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables palmitoyltransferase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables palmitoyltransferase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein-cysteine S-palmitoyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein-cysteine S-palmitoyltransferase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in adrenergic receptor signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within hair follicle development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in peptidyl-L-cysteine S-palmitoylation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in peptidyl-L-cysteine S-palmitoylation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in peptidyl-L-cysteine S-palmitoylation ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    acts_upstream_of_or_within protein palmitoylation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein palmitoylation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein targeting to membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of establishment of endothelial barrier IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of leukocyte adhesion to arterial endothelial cell IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of vascular associated smooth muscle contraction IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within sebaceous gland development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in Golgi apparatus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in Golgi apparatus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in Golgi apparatus ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in Golgi membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in endoplasmic reticulum IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    palmitoyltransferase ZDHHC21
    Names
    DHHC domain-containing cysteine-rich protein 21
    DHHC-21
    GABA-A receptor-associated membrane protein 3
    probable palmitoyltransferase ZDHHC21
    zinc finger DHHC domain-containing protein 21
    NP_080923.2
    XP_006538279.1
    XP_011248395.1
    XP_011248396.1
    XP_036020274.1
    XP_036020275.1
    XP_036020276.1
    XP_036020277.1
    XP_036020278.1
    XP_036020279.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_026647.4 → NP_080923.2  palmitoyltransferase ZDHHC21

      See identical proteins and their annotated locations for NP_080923.2

      Status: VALIDATED

      Source sequence(s)
      AK020293, AL671005, BC043110, BP753906
      Consensus CDS
      CCDS18294.1
      UniProtKB/Swiss-Prot
      Q6EMK1, Q80XQ3, Q9D270
      Related
      ENSMUSP00000030110.9, ENSMUST00000030110.15
      Conserved Domains (1) summary
      pfam01529
      Location:92 → 217
      DHHC; DHHC palmitoyltransferase

    RNA

    1. NR_149737.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AL671005, BC043110, BP753906, CJ102811

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000070.7 Reference GRCm39 C57BL/6J

      Range
      82716975..82778892 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036164381.1 → XP_036020274.1  palmitoyltransferase ZDHHC21 isoform X1

      UniProtKB/Swiss-Prot
      Q6EMK1, Q80XQ3, Q9D270
      Conserved Domains (1) summary
      pfam01529
      Location:92 → 217
      DHHC; DHHC palmitoyltransferase

    2. XM_036164383.1 → XP_036020276.1  palmitoyltransferase ZDHHC21 isoform X1

      UniProtKB/Swiss-Prot
      Q6EMK1, Q80XQ3, Q9D270
      Related
      ENSMUSP00000102859.2, ENSMUST00000107239.8
      Conserved Domains (1) summary
      pfam01529
      Location:92 → 217
      DHHC; DHHC palmitoyltransferase

    3. XM_011250094.4 → XP_011248396.1  palmitoyltransferase ZDHHC21 isoform X1

      See identical proteins and their annotated locations for XP_011248396.1

      UniProtKB/Swiss-Prot
      Q6EMK1, Q80XQ3, Q9D270
      Conserved Domains (1) summary
      pfam01529
      Location:92 → 217
      DHHC; DHHC palmitoyltransferase

    4. XM_036164382.1 → XP_036020275.1  palmitoyltransferase ZDHHC21 isoform X1

      UniProtKB/Swiss-Prot
      Q6EMK1, Q80XQ3, Q9D270
      Conserved Domains (1) summary
      pfam01529
      Location:92 → 217
      DHHC; DHHC palmitoyltransferase

    5. XM_006538216.4 → XP_006538279.1  palmitoyltransferase ZDHHC21 isoform X1

      See identical proteins and their annotated locations for XP_006538279.1

      UniProtKB/Swiss-Prot
      Q6EMK1, Q80XQ3, Q9D270
      Conserved Domains (1) summary
      pfam01529
      Location:92 → 217
      DHHC; DHHC palmitoyltransferase

    6. XM_036164386.1 → XP_036020279.1  palmitoyltransferase ZDHHC21 isoform X2

      Conserved Domains (1) summary
      pfam01529
      Location:2 → 120
      DHHC; DHHC palmitoyltransferase

    7. XM_011250093.4 → XP_011248395.1  palmitoyltransferase ZDHHC21 isoform X1

      See identical proteins and their annotated locations for XP_011248395.1

      UniProtKB/Swiss-Prot
      Q6EMK1, Q80XQ3, Q9D270
      Conserved Domains (1) summary
      pfam01529
      Location:92 → 217
      DHHC; DHHC palmitoyltransferase

    8. XM_036164385.1 → XP_036020278.1  palmitoyltransferase ZDHHC21 isoform X1

      UniProtKB/Swiss-Prot
      Q6EMK1, Q80XQ3, Q9D270
      Conserved Domains (1) summary
      pfam01529
      Location:92 → 217
      DHHC; DHHC palmitoyltransferase

    9. XM_036164384.1 → XP_036020277.1  palmitoyltransferase ZDHHC21 isoform X1

      UniProtKB/Swiss-Prot
      Q6EMK1, Q80XQ3, Q9D270
      Conserved Domains (1) summary
      pfam01529
      Location:92 → 217
      DHHC; DHHC palmitoyltransferase
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9D270.2 GenPept UniProtKB/Swiss-Prot:Q9D270

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