Cbln2 cerebellin 2 precursor protein [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Cbln2provided by MGI
Official Full Name: cerebellin 2 precursor proteinprovided by MGI
Primary source: MGI:MGI:88282
See related: Ensembl:ENSMUSG00000024647 AllianceGenome:MGI:88282
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: A730004O05; 6330593N19Rik
Summary: The protein encoded by this gene belongs to a family of secreted neuronal glycoproteins. The transcript is broadly expressed in the embryonic and adult brain with higher levels in some regions including the olfactory bulb, thalamus, and cerebral cortex. The protein can bind to presynaptic neurexins and induce synaptogenesis in cultured neurons. Null mutant mice are viable, fertile and do not display obvious neuroanatomical defects. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2014]
Expression: Biased expression in CNS E18 (RPKM 8.2), whole brain E14.5 (RPKM 7.6) and 6 other tissues See more
Orthologs: human all
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Genomic context

Location:: 18 E4; 18 58.63 cM

Exon count:: 7

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	18	NC_000084.7 (86727226..86736410)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	18	NC_000084.6 (86711061..86718283)

Chromosome 18 - NC_000084.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Cerebellin-2 regulates a serotonergic dorsal raphe circuit that controls compulsive behaviors.
Title: Cerebellin-2 regulates a serotonergic dorsal raphe circuit that controls compulsive behaviors.
Cbln2 and Cbln4 are expressed in distinct MHb neurons that contribute to different behaviors.
Title: Cbln2 and Cbln4 are expressed in distinct medial habenula-interpeduncular projections and contribute to different behavioral outputs.
Findings demonstrate that hippocampal synapse assembly and maintenance require a tripartite molecular complex in which the ligand Cbln2 binds with presynaptic neurexin 1beta (+S4) and postsynaptic GluD1.
Title: Postsynaptic δ1 glutamate receptor assembles and maintains hippocampal synapses via Cbln2 and neurexin.
Results show that Cbln1, Cbln2, and Cbln4 are abundantly expressed in nearly all brain regions, but exhibit strikingly different expression patterns and developmental dynamics. Using newly generated knockin reporter mice for Cbln2 and Cbln4, we find that Cbln2 and Cbln4 are not universally expressed in all neurons, but only in specific subsets of neurons.
Title: Cerebellins are differentially expressed in selective subsets of neurons throughout the brain.
that neurons expressing Cblns 1, 2, and 4 tend to occupy different laminar positions within the dorsal spinal cord
Title: Parcellation of cerebellins 1, 2, and 4 among different subpopulations of dorsal horn neurons in mouse spinal cord.
GluRdelta1 stimulated inhibitory synapse formation in the presence of Cbln1 or Cbln2
Title: Glutamate receptor δ1 induces preferentially inhibitory presynaptic differentiation of cortical neurons by interacting with neurexins through cerebellin precursor protein subtypes.
These results suggest that Cbln1 and Cbln2 play a role in synapse formation of cortical neurons by interacting with NRXNs containing S4.
Title: Differential interactions of cerebellin precursor protein (Cbln) subtypes and neurexin variants for synapse formation of cortical neurons.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (5) 1 citation
Targeted (2) 1 citation

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in maintenance of synapse structure	IBA Inferred from Biological aspect of Ancestor more info
involved_in maintenance of synapse structure	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within positive regulation of synapse assembly	IDA Inferred from Direct Assay more info	PubMed
involved_in spontaneous synaptic transmission	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of synapse assembly	IDA Inferred from Direct Assay more info	PubMed
involved_in synapse organization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in trans-synaptic signaling, modulating synaptic transmission	IDA Inferred from Direct Assay more info	PubMed
involved_in trans-synaptic signaling, modulating synaptic transmission	IEP Inferred from Expression Pattern more info	PubMed
involved_in trans-synaptic signaling, modulating synaptic transmission	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in extracellular space	IDA Inferred from Direct Assay more info	PubMed
is_active_in glutamatergic synapse	IDA Inferred from Direct Assay more info	PubMed
is_active_in glutamatergic synapse	IEP Inferred from Expression Pattern more info	PubMed
is_active_in glutamatergic synapse	IMP Inferred from Mutant Phenotype more info	PubMed
is_active_in glutamatergic synapse	NAS Non-traceable Author Statement more info	PubMed
is_active_in synapse	IBA Inferred from Biological aspect of Ancestor more info
is_active_in synaptic cleft	IDA Inferred from Direct Assay more info	PubMed
located_in synaptic cleft	IDA Inferred from Direct Assay more info	PubMed
is_active_in synaptic cleft	IMP Inferred from Mutant Phenotype more info	PubMed
is_active_in synaptic cleft	NAS Non-traceable Author Statement more info	PubMed
part_of trans-synaptic protein complex	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: cerebellin-2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001302356.2 → NP_001289285.1 cerebellin-2 precursor

See identical proteins and their annotated locations for NP_001289285.1

Status: REVIEWED

Description

Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 3. Variants 1, 2, 3, 4, 5 and 6 encode the same protein.

Source sequence(s)

AC115783

Consensus CDS

CCDS29388.1

UniProtKB/Swiss-Prot

Q8BGU2

Related

ENSMUSP00000068863.4, ENSMUST00000068423.10

Conserved Domains (1) summary

cl23878
Location:86 → 224

C1q; C1q domain
NM_001361142.1 → NP_001348071.1 cerebellin-2 precursor

Status: REVIEWED

Description

Transcript Variant: This variant (3) represents the longest transcript. Variants 1, 2, 3, 4, 5 and 6 encode the same protein.

Source sequence(s)

AC115783

Consensus CDS

CCDS29388.1

UniProtKB/Swiss-Prot

Q8BGU2

Conserved Domains (1) summary

cl23878
Location:86 → 224

C1q; C1q domain
NM_001361143.1 → NP_001348072.1 cerebellin-2 precursor

Status: REVIEWED

Description

Transcript Variant: This variant (4) differs in the 5' UTR compared to variant 3. Variants 1, 2, 3, 4, 5 and 6 encode the same protein.

Source sequence(s)

AC115783

Consensus CDS

CCDS29388.1

UniProtKB/Swiss-Prot

Q8BGU2

Conserved Domains (1) summary

cl23878
Location:86 → 224

C1q; C1q domain
NM_001361144.1 → NP_001348073.1 cerebellin-2 precursor

Status: REVIEWED

Description

Transcript Variant: This variant (5) differs in the 5' UTR compared to variant 3. Variants 1, 2, 3, 4, 5 and 6 encode the same protein.

Source sequence(s)

AC115783

Consensus CDS

CCDS29388.1

UniProtKB/Swiss-Prot

Q8BGU2

Related

ENSMUSP00000126810.2, ENSMUST00000169470.2

Conserved Domains (1) summary

cl23878
Location:86 → 224

C1q; C1q domain
NM_001361145.1 → NP_001348074.1 cerebellin-2 precursor

Status: REVIEWED

Description

Transcript Variant: This variant (6) differs in the 5' UTR compared to variant 3. Variants 1, 2, 3, 4, 5 and 6 encode the same protein.

Source sequence(s)

AC115783

Consensus CDS

CCDS29388.1

UniProtKB/Swiss-Prot

Q8BGU2

Conserved Domains (1) summary

cl23878
Location:86 → 224

C1q; C1q domain
NM_172633.4 → NP_766221.1 cerebellin-2 precursor

See identical proteins and their annotated locations for NP_766221.1

Status: REVIEWED

Description

Transcript Variant: This variant (1) differs in the 5' UTR compared to variant 3. Variants 1, 2, 3, 4, 5 and 6 encode the same protein.

Source sequence(s)

AC115783, AK032112, AK076174, BM948793, BX523565

Consensus CDS

CCDS29388.1

UniProtKB/Swiss-Prot

Q8BGU2

Related

ENSMUSP00000113695.2, ENSMUST00000122079.8

Conserved Domains (1) summary

cl23878
Location:86 → 224

C1q; C1q domain