Cbln3 cerebellin 3 precursor protein [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Cbln3provided by MGI
Official Full Name: cerebellin 3 precursor proteinprovided by MGI
Primary source: MGI:MGI:1889286
See related: Ensembl:ENSMUSG00000040380 AllianceGenome:MGI:1889286
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Summary: Predicted to be involved in maintenance of synapse structure. Located in extracellular space and synapse. Is active in parallel fiber to Purkinje cell synapse and synaptic cleft. Is expressed in several structures, including brain; genitourinary system; gut; respiratory system; and sensory organ. Orthologous to human CBLN3 (cerebellin 3 precursor). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Restricted expression toward cerebellum adult (RPKM 133.2) See more
Orthologs: human all
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Genomic context

Location:: 14 C3; 14 28.19 cM

Exon count:: 3

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	14	NC_000080.7 (56116377..56121713, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	14	NC_000080.6 (55878920..55884256, complement)

Chromosome 14 - NC_000080.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

immunohistochemical localization suggests the basis for anatomical convergence of the Cbln-GluRdelta2 signaling pathway in parallel fiber-Purkinje cell synapses
Title: Cbln1 accumulates and colocalizes with Cbln3 and GluRdelta2 at parallel fiber-Purkinje cell synapses in the mouse cerebellum.
Cbln3 is a secreted glycoprotein that participates in heteromeric complexes with Cbln1.
Title: Cbln1 is essential for interaction-dependent secretion of Cbln3.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (4) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Cbln3 (e-PCR), detects polymorphism
- UniSTS:178353

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in maintenance of synapse structure	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in Golgi apparatus	IEA Inferred from Electronic Annotation more info
located_in endoplasmic reticulum	IEA Inferred from Electronic Annotation more info
located_in extracellular space	IDA Inferred from Direct Assay more info	PubMed
located_in extracellular space	IGI Inferred from Genetic Interaction more info	PubMed
is_active_in parallel fiber to Purkinje cell synapse	IDA Inferred from Direct Assay more info	PubMed
is_active_in synapse	IBA Inferred from Biological aspect of Ancestor more info
located_in synapse	IDA Inferred from Direct Assay more info	PubMed
is_active_in synaptic cleft	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: cerebellin-3

Names: precerebellin 3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.