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    Ceacam12 CEA cell adhesion molecule 12 [ Mus musculus (house mouse) ]

    Gene ID: 67315, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Ceacam12provided by MGI
    Official Full Name
    CEA cell adhesion molecule 12provided by MGI
    Primary source
    MGI:MGI:1914565
    See related
    Ensembl:ENSMUSG00000030366 AllianceGenome:MGI:1914565
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Ceacam12C1; Ceacam12C3; Ceacam12-C1; Ceacam12-C3; 1600031J20Rik
    Summary
    Predicted to be involved in T cell activation and immune response. Predicted to be active in external side of plasma membrane. Is expressed in head. Orthologous to human CEACAM4 (CEA cell adhesion molecule 4) and PSG5 (pregnancy specific beta-1-glycoprotein 5). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Restricted expression toward placenta adult (RPKM 52.9) See more
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    Genomic context

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    See Ceacam12 in Genome Data Viewer
    Location:
    7 A2; 7 9.15 cM
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (17799854..17811911)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (18065929..18077986)

    Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene CEA cell adhesion molecule 13 Neighboring gene eukaryotic translation initiation factor pseudogene Neighboring gene STARR-seq mESC enhancer starr_18163 Neighboring gene IGF-like family member 3 Neighboring gene eukaryotic translation elongation factor 1 alpha 1 pseudogene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. HEMOGLOBINS IN MICE. SEGREGATION OF GENETIC FACTORS AFFECTING ELECTROPHORETIC MOBILITY AND SOLUBILITY. WOLFE HG, et al. J Hered, 1963 May-Jun. PMID 14051862
    2. Identification of a novel group of evolutionarily conserved members within the rapidly diverging murine Cea family. Zebhauser R, et al. Genomics, 2005 Nov. PMID 16139472
    3. Peg3 mutational effects on reproduction and placenta-specific gene families. Kim J, et al. PLoS One, 2013. PMID 24391757, Free PMC Article
    4. Genomic evolution of the placenta using co-option and duplication and divergence. Knox K, et al. Genome Res, 2008 May. PMID 18340042, Free PMC Article
    5. Genetic determinants of micronucleus formation in vivo. Adams DJ, et al. Nature, 2024 Mar. PMID 38355793, Free PMC Article

    See all (14) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 

    General gene information

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    Homology

    Clone Names

    • MGC117634

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in T cell activation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in immune response IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cellular_component ND
    No biological Data available
    more info
    		  
    is_active_in external side of plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    carcinoembryonic antigen-related cell adhesion molecule 12
    Names
    CEA-related cell adhesion molecule 12

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001162523.1 → NP_001155995.1  carcinoembryonic antigen-related cell adhesion molecule 12 isoform 2 precursor

      See identical proteins and their annotated locations for NP_001155995.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 3' coding region and 3' UTR, compared to variant 1. The resulting isoform (2) has a distinct C-terminus and is shorter than isoform 1.
      Source sequence(s)
      AC133088, AK005400, AK131656
      Consensus CDS
      CCDS52047.1
      UniProtKB/TrEMBL
      Q3V2Q3, Q9DAZ3
      Related
      ENSMUSP00000104127.3, ENSMUST00000108487.9
      Conserved Domains (1) summary
      cd05774
      Location:36 → 140
      Ig_CEACAM_D1; First immunoglobulin (Ig)-like domain of carcinoembryonic antigen (CEA) related cell adhesion molecule (CEACAM)

    2. NM_001162524.2 → NP_001155996.1  carcinoembryonic antigen-related cell adhesion molecule 12 isoform 3 precursor

      See identical proteins and their annotated locations for NP_001155996.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in the 3' coding region and 3' UTR, compared to variant 1. The resulting isoform (3) has a distinct C-terminus and is shorter than isoform 1.
      Source sequence(s)
      BC099443, BY705606
      Consensus CDS
      CCDS52048.1
      UniProtKB/TrEMBL
      Q9DAS5, Q9DAZ3
      Related
      ENSMUSP00000104123.2, ENSMUST00000108483.2
      Conserved Domains (1) summary
      cd05774
      Location:36 → 140
      Ig_CEACAM_D1; First immunoglobulin (Ig)-like domain of carcinoembryonic antigen (CEA) related cell adhesion molecule (CEACAM)

    3. NM_026087.3 → NP_080363.2  carcinoembryonic antigen-related cell adhesion molecule 12 isoform 1 precursor

      See identical proteins and their annotated locations for NP_080363.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the shortest transcript and encodes the longest isoform (1).
      Source sequence(s)
      AC133088, AK005400, AK145926
      Consensus CDS
      CCDS20867.1
      UniProtKB/TrEMBL
      Q3UKP4, Q9DAZ3
      Related
      ENSMUSP00000032520.3, ENSMUST00000032520.9
      Conserved Domains (1) summary
      cd05774
      Location:36 → 140
      Ig_CEACAM_D1; First immunoglobulin (Ig)-like domain of carcinoembryonic antigen (CEA) related cell adhesion molecule (CEACAM)

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000073.7 Reference GRCm39 C57BL/6J

      Range
      17799854..17811911
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version

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