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    Tagln transgelin [ Mus musculus (house mouse) ]

    Gene ID: 21345, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Taglnprovided by MGI
    Official Full Name
    transgelinprovided by MGI
    Primary source
    MGI:MGI:106012
    See related
    Ensembl:ENSMUSG00000032085 AllianceGenome:MGI:106012
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Sm22; Sm22a; Ws310
    Summary
    This gene encodes a smooth muscle cell-specific cytoskeletal protein. The encoded protein is structurally similar to calponin, an actin-binding protein. In mouse models of atherosclerosis the gene product may be involved in plaque cell and atherosclerotic lesion formation during atherogenesis. [provided by RefSeq, Mar 2010]
    Expression
    Biased expression in bladder adult (RPKM 3112.1), stomach adult (RPKM 1002.7) and 5 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Tagln in Genome Data Viewer
    Location:
    9 A5.2; 9 25.36 cM
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (45840926..45847356, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (45929628..45936058, complement)

    Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene CapStarr-seq enhancer MGSCv37_chr9:45655339-45655522 Neighboring gene beta-site APP cleaving enzyme 1 Neighboring gene ring finger protein 214 Neighboring gene predicted gene, 24646 Neighboring gene STARR-seq mESC enhancer starr_24009 Neighboring gene proprotein convertase subtilisin/kexin type 7 Neighboring gene microRNA 7087 Neighboring gene SID1 transmembrane family, member 2 Neighboring gene RIKEN cDNA A830035O19 gene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. SM22α Loss Contributes to Apoptosis of Vascular Smooth Muscle Cells via Macrophage-Derived circRasGEF1B. Lv P, et al. Oxid Med Cell Longev, 2021. PMID 33859778, Free PMC Article
    2. Transcriptome profiling reveals that the SM22α-regulated molecular pathways contribute to vascular pathology. Chen R, et al. J Mol Cell Cardiol, 2014 Jul. PMID 24735829
    3. SM22α cell-specific HIF stabilization mitigates hyperoxia-induced neonatal lung injury. Ito R, et al. Am J Physiol Lung Cell Mol Physiol, 2022 Aug 1. PMID 35762602, Free PMC Article
    4. The glomerular parietal epithelial cell's responses are influenced by SM22 alpha levels. Naito S, et al. BMC Nephrol, 2014 Nov 6. PMID 25376243, Free PMC Article
    5. Sm22α transcription occurs at the early onset of the cardiovascular system and the intron 1 is dispensable for its transcription in smooth muscle cells during mouse development. Yang M, et al. Int J Physiol Pathophysiol Pharmacol, 2010. PMID 20428474, Free PMC Article

    See all (353) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Loss of prolyl hydroxylase 1 and 2 in SM22alpha-expressing cells prevents Hypoxia-Induced pulmonary hypertension.
      Title: Loss of prolyl hydroxylase 1 and 2 in SM22α-expressing cells prevents Hypoxia-Induced pulmonary hypertension.
    2. Hypoxia-Inducible Factor-1alpha in SM22alpha-Expressing Cells Modulates Alveolarization.
      Title: Hypoxia-Inducible Factor-1α in SM22α-Expressing Cells Modulates Alveolarization.
    3. SM22alpha Deletion Contributes to Neurocognitive Impairment in Mice through Modulating Vascular Smooth Muscle Cell Phenotypes.
      Title: SM22α Deletion Contributes to Neurocognitive Impairment in Mice through Modulating Vascular Smooth Muscle Cell Phenotypes.
    4. SM22alpha cell-specific HIF stabilization mitigates hyperoxia-induced neonatal lung injury.
      Title: SM22α cell-specific HIF stabilization mitigates hyperoxia-induced neonatal lung injury.
    5. Deletion of SM22alpha disrupts the structure and function of caveolae and T-tubules in cardiomyocytes, contributing to heart failure.
      Title: Deletion of SM22α disrupts the structure and function of caveolae and T-tubules in cardiomyocytes, contributing to heart failure.
    6. Smooth muscle protein 22alpha-Cre recombination in resting cardiac fibroblasts and hematopoietic precursors.
      Title: Smooth muscle protein 22α-Cre recombination in resting cardiac fibroblasts and hematopoietic precursors.
    7. Colonic healing requires Wnt produced by epithelium as well as Tagln+ and Acta2+ stromal cells.
      Title: Colonic healing requires Wnt produced by epithelium as well as Tagln+ and Acta2+ stromal cells.
    8. The canonical smooth muscle cell marker TAGLN is present in endothelial cells and is involved in angiogenesis.
      Title: The canonical smooth muscle cell marker TAGLN is present in endothelial cells and is involved in angiogenesis.
    9. SM22alpha(+) vascular mural cells are essential for vessel stability in tumors and undergo phenotype transition regulated by Notch signaling.
      Title: SM22α(+) vascular mural cells are essential for vessel stability in tumors and undergo phenotype transition regulated by Notch signaling.
    10. Smooth muscle 22alpha deficiency impairs oxytocin-induced uterine contractility in mice at full-term pregnancy.
      Title: Smooth muscle 22α deficiency impairs oxytocin-induced uterine contractility in mice at full-term pregnancy.
    Submit: New GeneRIF Correction See all GeneRIFs (42)

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (6) 
    • Targeted (6)  1 citation

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Process Evidence Code Pubs
    NOT acts_upstream_of_or_within cytoskeleton organization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in epithelial cell differentiation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in epithelial cell differentiation ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    transgelin
    Names
    SM22-alpha
    Sm22alpha
    actin-associated protein p27
    smooth muscle protein 22-alpha

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_011526.5 → NP_035656.1  transgelin

      See identical proteins and their annotated locations for NP_035656.1

      Status: REVIEWED

      Source sequence(s)
      AC122273, AK077235
      Consensus CDS
      CCDS23137.1
      UniProtKB/Swiss-Prot
      P37804, Q545W0
      Related
      ENSMUSP00000034590.3, ENSMUST00000034590.4
      Conserved Domains (3) summary
      COG5199
      Location:14 → 189
      SCP1; Calponin [Cytoskeleton]
      cd00014
      Location:25 → 137
      CH; Calponin homology domain; actin-binding domain which may be present as a single copy or in tandem repeats (which increases binding affinity). The CH domain is found in cytoskeletal and signal transduction proteins, including actin-binding proteins like ...
      pfam00402
      Location:175 → 198
      Calponin; Calponin family repeat

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000075.7 Reference GRCm39 C57BL/6J

      Range
      45840926..45847356 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P37804.3 GenPept UniProtKB/Swiss-Prot:P37804

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
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