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    Dop1a DOP1 leucine zipper like protein A [ Mus musculus (house mouse) ]

    Gene ID: 320615, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Dop1aprovided by MGI
    Official Full Name
    DOP1 leucine zipper like protein Aprovided by MGI
    Primary source
    MGI:MGI:1289294
    See related
    Ensembl:ENSMUSG00000034973 AllianceGenome:MGI:1289294
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Dopey1; C130028L17; D9Ertd809e; B130005I07Rik
    Summary
    Predicted to be involved in Golgi to endosome transport and protein transport. Predicted to be located in Golgi-associated vesicle. Predicted to be active in endosome and trans-Golgi network. Is expressed in cerebellum; neocortex; and spleen. Orthologous to human DOP1A (DOP1 leucine zipper like protein A). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in CNS E18 (RPKM 6.0), CNS E14 (RPKM 5.1) and 27 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Dop1a in Genome Data Viewer
    Location:
    9 E3.1; 9 46.58 cM
    Exon count:
    39
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (86349194..86436683)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (86467141..86555806)

    Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene VISTA enhancer mm1553 Neighboring gene ribosomal protein L5 pseudogene Neighboring gene STARR-seq mESC enhancer starr_24831 Neighboring gene STARR-seq mESC enhancer starr_24832 Neighboring gene sorting nexin 4 pseudogene Neighboring gene ubiquitin protein ligase E3D Neighboring gene STARR-positive B cell enhancer ABC_E9332 Neighboring gene STARR-positive B cell enhancer ABC_E10572 Neighboring gene phosphoglucomutase 3 Neighboring gene RWD domain containing 2A Neighboring gene malic enzyme 1, NADP(+)-dependent, cytosolic Neighboring gene STARR-seq mESC enhancer starr_24835 Neighboring gene RIKEN cDNA A330041J22 gene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Genome-wide screening and identification of novel proteolytic cleavage targets of caspase-8 and -10 in vitro. Bae S, et al. Int J Mol Med, 2008 Mar. PMID 18288386
    2. A mutation in the Srrm4 gene causes alternative splicing defects and deafness in the Bronx waltzer mouse. Nakano Y, et al. PLoS Genet, 2012. PMID 23055939, Free PMC Article
    3. Overlapping Activities of Two Neuronal Splicing Factors Switch the GABA Effect from Excitatory to Inhibitory by Regulating REST. Nakano Y, et al. Cell Rep, 2019 Apr 16. PMID 30995482, Free PMC Article
    4. Voltage-dependent conformational changes of Kv1.3 channels activate cell proliferation. Cidad P, et al. J Cell Physiol, 2021 Jun. PMID 33230847
    5. Prediction of the coding sequences of mouse homologues of KIAA gene: IV. The complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries. Okazaki N, et al. DNA Res, 2004 Jun 30. PMID 15368895

    See all (21) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • KIAA1117, MGC49390

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in Golgi to endosome transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in protein transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in Golgi membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in Golgi-associated vesicle ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in endosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in trans-Golgi network IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    protein DOP1A; protein dopey-1
    Names
    dopey family member 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001408204.1 → NP_001395133.1  protein DOP1A isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC157998

    2. NM_001408205.1 → NP_001395134.1  protein DOP1A isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC157998

    3. NM_177208.4 → NP_796182.2  protein DOP1A isoform 1

      See identical proteins and their annotated locations for NP_796182.2

      Status: VALIDATED

      Source sequence(s)
      AC157998
      Consensus CDS
      CCDS52876.1
      UniProtKB/Swiss-Prot
      Q80XM5, Q8BIX5, Q8BIY4, Q8BL99, Q8BLK8
      UniProtKB/TrEMBL
      H7BWZ9
      Conserved Domains (2) summary
      pfam04118
      Location:13 → 297
      Dopey_N; Dopey, N-terminal
      cl04407
      Location:2088 → 2324
      Dopey_N; Dopey, N-terminal

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000075.7 Reference GRCm39 C57BL/6J

      Range
      86349194..86436683
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006511239.4 → XP_006511302.1  protein dopey-1 isoform X7

      UniProtKB/Swiss-Prot
      Q80XM5, Q8BIX5, Q8BIY4, Q8BL99, Q8BLK8
      Conserved Domains (2) summary
      pfam04118
      Location:13 → 297
      Dopey_N; Dopey, N-terminal
      cl04407
      Location:2089 → 2325
      Dopey_N; Dopey, N-terminal

    2. XM_006511240.4 → XP_006511303.1  protein dopey-1 isoform X8

      See identical proteins and their annotated locations for XP_006511303.1

      UniProtKB/Swiss-Prot
      Q80XM5, Q8BIX5, Q8BIY4, Q8BL99, Q8BLK8
      UniProtKB/TrEMBL
      H7BWZ9
      Related
      ENSMUSP00000140740.2, ENSMUST00000190957.7
      Conserved Domains (2) summary
      pfam04118
      Location:13 → 297
      Dopey_N; Dopey, N-terminal
      cl04407
      Location:2088 → 2324
      Dopey_N; Dopey, N-terminal

    3. XM_036155068.1 → XP_036010961.1  protein dopey-1 isoform X12

      UniProtKB/Swiss-Prot
      Q80XM5, Q8BIX5, Q8BIY4, Q8BL99, Q8BLK8
      Conserved Domains (2) summary
      pfam04118
      Location:13 → 297
      Dopey_N; Dopey, N-terminal
      cl04407
      Location:2078 → 2314
      Dopey_N; Dopey, N-terminal

    4. XM_030244420.1 → XP_030100280.1  protein dopey-1 isoform X9

      UniProtKB/Swiss-Prot
      Q80XM5, Q8BIX5, Q8BIY4, Q8BL99, Q8BLK8
      Conserved Domains (2) summary
      pfam04118
      Location:13 → 295
      Dopey_N; Dopey, N-terminal
      cl04407
      Location:2080 → 2316
      Dopey_N; Dopey, N-terminal

    5. XM_006511241.4 → XP_006511304.1  protein dopey-1 isoform X11

      UniProtKB/Swiss-Prot
      Q80XM5, Q8BIX5, Q8BIY4, Q8BL99, Q8BLK8
      Conserved Domains (2) summary
      pfam04118
      Location:13 → 295
      Dopey_N; Dopey, N-terminal
      cl04407
      Location:2079 → 2315
      Dopey_N; Dopey, N-terminal

    6. XM_017313433.2 → XP_017168922.1  protein dopey-1 isoform X1

      UniProtKB/Swiss-Prot
      Q80XM5, Q8BIX5, Q8BIY4, Q8BL99, Q8BLK8
      Conserved Domains (2) summary
      pfam04118
      Location:13 → 297
      Dopey_N; Dopey, N-terminal
      cl04407
      Location:2089 → 2325
      Dopey_N; Dopey, N-terminal

    7. XM_006511236.4 → XP_006511299.1  protein dopey-1 isoform X2

      UniProtKB/Swiss-Prot
      Q80XM5, Q8BIX5, Q8BIY4, Q8BL99, Q8BLK8
      Conserved Domains (2) summary
      pfam04118
      Location:13 → 297
      Dopey_N; Dopey, N-terminal
      cl04407
      Location:2088 → 2324
      Dopey_N; Dopey, N-terminal

    8. XM_006511237.4 → XP_006511300.1  protein dopey-1 isoform X4

      UniProtKB/Swiss-Prot
      Q80XM5, Q8BIX5, Q8BIY4, Q8BL99, Q8BLK8
      Conserved Domains (2) summary
      pfam04118
      Location:13 → 297
      Dopey_N; Dopey, N-terminal
      cl04407
      Location:2079 → 2315
      Dopey_N; Dopey, N-terminal

    9. XM_036155066.1 → XP_036010959.1  protein dopey-1 isoform X6

      UniProtKB/Swiss-Prot
      Q80XM5, Q8BIX5, Q8BIY4, Q8BL99, Q8BLK8
      Conserved Domains (2) summary
      pfam04118
      Location:13 → 297
      Dopey_N; Dopey, N-terminal
      cl04407
      Location:2078 → 2314
      Dopey_N; Dopey, N-terminal

    10. XM_017313434.2 → XP_017168923.1  protein dopey-1 isoform X3

      UniProtKB/Swiss-Prot
      Q80XM5, Q8BIX5, Q8BIY4, Q8BL99, Q8BLK8
      Conserved Domains (2) summary
      pfam04118
      Location:13 → 295
      Dopey_N; Dopey, N-terminal
      cl04407
      Location:2080 → 2316
      Dopey_N; Dopey, N-terminal

    11. XM_006511238.4 → XP_006511301.1  protein dopey-1 isoform X5

      UniProtKB/Swiss-Prot
      Q80XM5, Q8BIX5, Q8BIY4, Q8BL99, Q8BLK8
      Conserved Domains (2) summary
      pfam04118
      Location:13 → 295
      Dopey_N; Dopey, N-terminal
      cl04407
      Location:2079 → 2315
      Dopey_N; Dopey, N-terminal

    12. XM_006511235.4 → XP_006511298.1  protein dopey-1 isoform X1

      UniProtKB/Swiss-Prot
      Q80XM5, Q8BIX5, Q8BIY4, Q8BL99, Q8BLK8
      Conserved Domains (2) summary
      pfam04118
      Location:13 → 297
      Dopey_N; Dopey, N-terminal
      cl04407
      Location:2089 → 2325
      Dopey_N; Dopey, N-terminal

    13. XM_017313435.1 → XP_017168924.1  protein dopey-1 isoform X15

      Conserved Domains (1) summary
      cl04407
      Location:1526 → 1762
      Dopey_N; Dopey, N-terminal

    14. XM_011242758.3 → XP_011241060.1  protein dopey-1 isoform X13

      Conserved Domains (1) summary
      cl04407
      Location:1526 → 1762
      Dopey_N; Dopey, N-terminal

    15. XM_011242759.3 → XP_011241061.1  protein dopey-1 isoform X14

      Conserved Domains (1) summary
      cl04407
      Location:1525 → 1761
      Dopey_N; Dopey, N-terminal

    RNA

    1. XR_004935458.1 RNA Sequence

    2. XR_379426.5 RNA Sequence

    3. XR_004935457.1 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8BL99.2 GenPept UniProtKB/Swiss-Prot:Q8BL99

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