Tank TRAF family member-associated Nf-kappa B activator [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Tankprovided by MGI
Official Full Name: TRAF family member-associated Nf-kappa B activatorprovided by MGI
Primary source: MGI:MGI:107676
See related: Ensembl:ENSMUSG00000064289 AllianceGenome:MGI:107676
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: I-TRAF; E430026L09Rik
Summary: Enables molecular function inhibitor activity. Involved in negative regulation of tumor necrosis factor-mediated signaling pathway. Predicted to be located in cytosol. Predicted to be part of protein-containing complex. Predicted to be active in cytoplasm. Is expressed in several structures, including alimentary system; brain; genitourinary system; hemolymphoid system gland; and liver and biliary system. Orthologous to human TANK (TRAF family member associated NFKB activator). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Ubiquitous expression in bladder adult (RPKM 6.0), frontal lobe adult (RPKM 5.6) and 26 other tissues See more
Orthologs: human all
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Genomic context

Location:: 2 C1.3; 2 35.56 cM

Exon count:: 14

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	2	NC_000068.8 (61408901..61484515)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	2	NC_000068.7 (61578557..61654171)

Chromosome 2 - NC_000068.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Findings suggest that the cortical neuroimmune regulator TANK is involved in cortical aversive emotion processing and related control of alcohol drinking behavior. A tank knock out mouse model suggests a role of TANK in alcohol drinking, anxiety-related behavior, as well as alcohol exposure induced activation of insular cortex NF-kappaB.
Title: The Cortical Neuroimmune Regulator TANK Affects Emotional Processing and Enhances Alcohol Drinking: A Translational Study.
TANK is expressed in DRG neurons. TANK is increased by peripheral nerve injury. the regulation of TANK expression is, at least in part, controlled by the injury-associated transcription factor Sox11.
Title: TRAF family member-associated NF-kappa B activator (TANK) expression increases in injured sensory neurons and is transcriptionally regulated by Sox11.
Tank, whose expression is increased during osteoclastogenesis, inhibits osteoclast formation, activity and survival, by regulating NF-kappaB activity and c-FLIP expression.
Title: TRAF family member-associated NF-κB activator (TANK) induced by RANKL negatively regulates osteoclasts survival and function.
TANK is critical for osteoclastogenesis by regulating NF-kappaB, and is also important for proper bone remodeling.
Title: TRAF family member-associated NF-κB activator (TANK) is a negative regulator of osteoclastogenesis and bone formation.
role for TANK in enabling the canonical IKKs and the IKK-related kinases to regulate each other, which is required to limit the strength of TLR signaling and ultimately, prevent autoimmunity
Title: The TRAF-associated protein TANK facilitates cross-talk within the IkappaB kinase family during Toll-like receptor signaling.
MARCH5 is an authentic E3 ubiquitin ligase and catalyzes K63-linked polyubiquitination of TANK. MARCH5 modulates TLR7 signaling via releasing the inhibitory action of TANK toward TRAF6.
Title: Mitochondrial ubiquitin ligase MARCH5 promotes TLR7 signaling by attenuating TANK action.
constitutive TLR signaling by intestinal commensal microflora is suppressed by TANK.
Title: TANK is a negative regulator of Toll-like receptor signaling and is critical for the prevention of autoimmune nephritis.
TANK may be a critical adaptor that regulates the assembly of the TANK-binding kinase 1-inducible IkappaB kinase complex with upstream signaling molecules in multiple antiviral pathways
Title: Modulation of the interferon antiviral response by the TBK1/IKKi adaptor protein TANK.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (2) 1 citation
Targeted (1) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Tank (e-PCR), detects polymorphism
- UniSTS:144544

NoName (e-PCR)
- UniSTS:234407

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
contributes_to cysteine-type deubiquitinase activity	ISO Inferred from Sequence Orthology more info
contributes_to cysteine-type deubiquitinase activity	ISS Inferred from Sequence or Structural Similarity more info
enables deubiquitinase activator activity	ISO Inferred from Sequence Orthology more info
enables deubiquitinase activator activity	ISS Inferred from Sequence or Structural Similarity more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables molecular adaptor activity	IEA Inferred from Electronic Annotation more info
enables molecular adaptor activity	ISO Inferred from Sequence Orthology more info
enables molecular function inhibitor activity	IDA Inferred from Direct Assay more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables ubiquitin protein ligase binding	IEA Inferred from Electronic Annotation more info
enables ubiquitin protein ligase binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in DNA damage response	ISO Inferred from Sequence Orthology more info
involved_in DNA damage response	ISS Inferred from Sequence or Structural Similarity more info
involved_in cellular response to interleukin-1	ISO Inferred from Sequence Orthology more info
involved_in cellular response to interleukin-1	ISS Inferred from Sequence or Structural Similarity more info
involved_in cellular response to ionizing radiation	ISO Inferred from Sequence Orthology more info
involved_in cellular response to ionizing radiation	ISS Inferred from Sequence or Structural Similarity more info
involved_in cellular response to tumor necrosis factor	ISO Inferred from Sequence Orthology more info
involved_in cellular response to tumor necrosis factor	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of canonical NF-kappaB signal transduction	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of canonical NF-kappaB signal transduction	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of tumor necrosis factor-mediated signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of protein deubiquitination	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of protein deubiquitination	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of type I interferon production	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of type I interferon production	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of ubiquitin-specific protease activity	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of ubiquitin-specific protease activity	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytosol	IEA Inferred from Electronic Annotation more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
part_of protein-containing complex	ISO Inferred from Sequence Orthology more info
part_of protein-containing complex	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: TRAF family member-associated NF-kappa-B activator

Names: TRAF-interacting protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001164071.1 → NP_001157543.1 TRAF family member-associated NF-kappa-B activator isoform 1

See identical proteins and their annotated locations for NP_001157543.1

Status: VALIDATED

Description

Transcript Variant: This variant (1) encodes isoform 1. Variants 1 and 4 both encode the same isoform (1).

Source sequence(s)

AK147727, AL845291, BB660164

Consensus CDS

CCDS50592.1

UniProtKB/TrEMBL

Q3UGW0

Related

ENSMUSP00000108120.3, ENSMUST00000112501.9

Conserved Domains (1) summary

pfam12845
Location:134 → 185

TBD; TBD domain
NM_001164072.1 → NP_001157544.1 TRAF family member-associated NF-kappa-B activator isoform 2

See identical proteins and their annotated locations for NP_001157544.1

Status: VALIDATED

Description

Transcript Variant: This variant (2) lacks an alternate exon in the 5' UTR and uses an alternate in-frame splice site in the central coding region, compared to variant 1. The resulting isoform (2) lacks one internal residue, compared to isoform 1.

Source sequence(s)

AK147727, AK165420, AL845291, BB660164

Consensus CDS

CCDS50593.1

UniProtKB/TrEMBL

Q3TNB4, Q8C2D3

Related

ENSMUSP00000108114.2, ENSMUST00000112495.8

Conserved Domains (2) summary

pfam05557
Location:25 → 83

MAD; Mitotic checkpoint protein

pfam12845
Location:131 → 184

TBD; TBD domain
NM_001355267.1 → NP_001342196.1 TRAF family member-associated NF-kappa-B activator isoform 1

Status: VALIDATED

Description

Transcript Variant: This variant (4) differs in the 5' UTR compared to variant 1. Variants 1 and 4 both encode the same isoform (1).

Source sequence(s)

AL845291, AL928859

Consensus CDS

CCDS50592.1

UniProtKB/TrEMBL

Q3UGW0

Conserved Domains (1) summary

pfam12845
Location:134 → 185

TBD; TBD domain
NM_001355268.1 → NP_001342197.1 TRAF family member-associated NF-kappa-B activator isoform 4

Status: VALIDATED

Source sequence(s)

AL845291, AL928859

Related

ENSMUST00000141544.8

Conserved Domains (1) summary

pfam12845
Location:2 → 52

TBD; TBD domain
NM_001374667.1 → NP_001361596.1 TRAF family member-associated NF-kappa-B activator isoform 5

Status: VALIDATED

Source sequence(s)

AL845291, AL928859

Consensus CDS

CCDS89491.1

UniProtKB/TrEMBL

A2AR76, Q3TNB4

Related

ENSMUSP00000108121.2, ENSMUST00000112502.8

Conserved Domains (2) summary

pfam05557
Location:59 → 117

MAD; Mitotic checkpoint protein

pfam12845
Location:165 → 218

TBD; TBD domain
NM_001378922.1 → NP_001365851.1 TRAF family member-associated NF-kappa-B activator isoform 6

Status: VALIDATED

Source sequence(s)

AL845291, AL928859

Conserved Domains (1) summary

pfam12845
Location:2 → 51

TBD; TBD domain
NM_011529.2 → NP_035659.1 TRAF family member-associated NF-kappa-B activator isoform 3

See identical proteins and their annotated locations for NP_035659.1

Status: VALIDATED

Description

Transcript Variant: This variant (3) represents use of an alternate promoter and 5' UTR and uses an upstream start codon, compared to variant 1. The resulting isoform (3) has a longer N-terminus, compared to isoform 1.

Source sequence(s)

AL845291, U59864

Consensus CDS

CCDS16061.1

UniProtKB/Swiss-Prot

P70347, Q61178

UniProtKB/TrEMBL

Q3UGW0

Related

ENSMUSP00000077219.3, ENSMUST00000078074.9

Conserved Domains (1) summary

pfam12845
Location:166 → 218

TBD; TBD domain

RNA

NR_149323.1 RNA Sequence

Status: VALIDATED

Source sequence(s)

AL845291, AL928859
NR_149324.1 RNA Sequence

Status: VALIDATED

Source sequence(s)

AL845291, AL928859

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000068.8 Reference GRCm39 C57BL/6J

Range

61408901..61484515

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_036160230.1 → XP_036016123.1 TRAF family member-associated NF-kappa-B activator isoform X1

UniProtKB/TrEMBL

A2AR78

Conserved Domains (1) summary

pfam12845
Location:166 → 218

TBD; TBD domain
XM_036160231.1 → XP_036016124.1 TRAF family member-associated NF-kappa-B activator isoform X3

UniProtKB/TrEMBL

A2AR78

Conserved Domains (1) summary

pfam12845
Location:132 → 184

TBD; TBD domain
XM_036160232.1 → XP_036016125.1 TRAF family member-associated NF-kappa-B activator isoform X4

UniProtKB/TrEMBL

A2AR78

Conserved Domains (1) summary

pfam12845
Location:131 → 183

TBD; TBD domain
XM_017316913.3 → XP_017172402.1 TRAF family member-associated NF-kappa-B activator isoform X2

UniProtKB/TrEMBL

Q3TNB4, Q8C2D3

Conserved Domains (2) summary

pfam05557
Location:25 → 83

MAD; Mitotic checkpoint protein

pfam12845
Location:131 → 184

TBD; TBD domain
XM_036160236.1 → XP_036016129.1 TRAF family member-associated NF-kappa-B activator isoform X5

Conserved Domains (1) summary

pfam12845
Location:2 → 51

TBD; TBD domain
XM_036160233.1 → XP_036016126.1 TRAF family member-associated NF-kappa-B activator isoform X5

Conserved Domains (1) summary

pfam12845
Location:2 → 51

TBD; TBD domain
XM_036160237.1 → XP_036016130.1 TRAF family member-associated NF-kappa-B activator isoform X5

Conserved Domains (1) summary

pfam12845
Location:2 → 51

TBD; TBD domain
XM_036160235.1 → XP_036016128.1 TRAF family member-associated NF-kappa-B activator isoform X5

Conserved Domains (1) summary

pfam12845
Location:2 → 51

TBD; TBD domain
XM_036160234.1 → XP_036016127.1 TRAF family member-associated NF-kappa-B activator isoform X5

Conserved Domains (1) summary

pfam12845
Location:2 → 51

TBD; TBD domain