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    Cyp4ac2 Cytochrome P450 4ac2 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 33755, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Cyp4ac2provided by FlyBase
    Official Full Name
    Cytochrome P450 4ac2provided by FlyBase
    Primary source
    FLYBASE:FBgn0031694
    Locus tag
    Dmel_CG17970
    See related
    AllianceGenome:FB:FBgn0031694
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    4ac2; CG17970; CYP4ac2; CYP4AC2; Dmel\CG17970
    Summary
    Predicted to enable several functions, including heme binding activity; iron ion binding activity; and monooxygenase activity. Is expressed in adult head. Human ortholog(s) of this gene implicated in Bietti crystalline corneoretinal dystrophy. Orthologous to human CYP4V2 (cytochrome P450 family 4 subfamily V member 2). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Cyp4ac2 in Genome Data Viewer
    Location:
    25D2-25D2; 2-16 cM
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (5266392..5268455)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (5266392..5268455)

    Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene thickveins Neighboring gene long non-coding RNA:CR44744 Neighboring gene Cytochrome P450 4ac1 Neighboring gene Cytochrome P450 4ac3 Neighboring gene Ninein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Genes and pathways affected by CAG-repeat RNA-based toxicity in Drosophila. Shieh SY, et al. Hum Mol Genet, 2011 Dec 15. PMID 21933837, Free PMC Article
    2. Cytochrome P450-dependent metabolism of caffeine in Drosophila melanogaster. Coelho A, et al. PLoS One, 2015. PMID 25671424, Free PMC Article
    3. Loss of Drosophila Clueless differentially affects the mitochondrial proteome compared to loss of Sod2 and Pink1. Sen A, et al. Front Physiol, 2022. PMID 36388112, Free PMC Article
    4. The molecular evolution of cytochrome P450 genes within and between drosophila species. Good RT, et al. Genome Biol Evol, 2014 Apr 20. PMID 24751979, Free PMC Article
    5. Characterization of Drosophila melanogaster cytochrome P450 genes. Chung H, et al. Proc Natl Acad Sci U S A, 2009 Apr 7. PMID 19289821, Free PMC Article

    See all (33) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables heme binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables iron ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables monooxygenase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    cytochrome P450 4ac2
    Names
    CG17970-PB
    Cyp4ac2-PB
    cytochrome P450
    NP_608917.3

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033779.5 Reference assembly

      Range
      5266392..5268455
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_135073.3 → NP_608917.3  cytochrome P450 4ac2 [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_608917.3

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q4V4C1, Q9VMS8
      Conserved Domains (1) summary
      pfam00067
      Location:57 → 505
      p450; Cytochrome P450
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9VMS8.4 Q9VMS8

    Gene LinkOut

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