verm vermiform [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: vermprovided by FlyBase
Official Full Name: vermiformprovided by FlyBase
Primary source: FLYBASE:FBgn0261341
Locus tag: Dmel_CG8756
See related: AllianceGenome:FB:FBgn0261341
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: CG8756; DmCDA2; Dmel\CG8756; hlm; l(3)76BDx; LCBP1; N63; Verm
Summary: Predicted to enable chitin binding activity. Involved in chitin-based cuticle development; respiratory system development; and visual behavior. Located in cell surface; chitin-based extracellular matrix; and extracellular region. Is expressed in several structures, including adult head; lamina; presumptive embryonic/larval tracheal system; retina; and tracheal lumen. [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Genomic context

Location:: 76C1-76C1; 3-46 cM

Exon count:: 8

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	3L	NT_037436.4 (19690033..19695260, complement)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	3L	NT_037436.3 (19683133..19688360, complement)

Chromosome 3L - NT_037436.4 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

DmCDA1 (Serpentine, Serp) and DmCDA2 (Vermiform, Verm) have distinct functions during Drosophila adult wing cuticle differentiation. Chitosan staining revealed that Serp is the major enzyme responsible for chitin deacetylation during wing cuticle formation, while Verm does not seem to be needed for this process. Indeed, it is questionable whether Verm is a chitin deacetylase at all.
Title: The putative chitin deacetylases Serpentine and Vermiform have non-redundant functions during Drosophila wing development.
Serpentine (serp) and Vermiform (verm) encode similar proteins with an LDL-receptor ligand binding motif and chitin binding and deacetylation domains and are required for the normal fibrillar structure of chitin.
Title: serpentine and vermiform encode matrix proteins with chitin binding and deacetylation domains that limit tracheal tube length in Drosophila.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
enables chitin binding	IEA Inferred from Electronic Annotation more info
NOT enables chitin deacetylase activity	IKR Inferred from Key Residues more info	PubMed

Process	Evidence Code	Pubs
involved_in adult chitin-based cuticle development	IBA Inferred from Biological aspect of Ancestor more info
involved_in adult chitin-based cuticle development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in carbohydrate metabolic process	IEA Inferred from Electronic Annotation more info
involved_in chitin-based cuticle development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in dorsal trunk growth, open tracheal system	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in larval chitin-based cuticle development	IBA Inferred from Biological aspect of Ancestor more info
involved_in larval chitin-based cuticle development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in open tracheal system development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of tube length, open tracheal system	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of tube length, open tracheal system	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in trachea morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in visual behavior	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in cell surface	IDA Inferred from Direct Assay more info	PubMed
located_in chitin-based extracellular matrix	IDA Inferred from Direct Assay more info	PubMed
located_in extracellular region	IDA Inferred from Direct Assay more info	PubMed
located_in extracellular region	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: vermiform

Names: CG8756-PG; CG8756-PH; CG8756-PI; LDLa domain containing chitin binding protein 1; LDLa domain containing chitin binding protein-1; helmsman; verm-PG; verm-PH; verm-PI

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NT_037436.4 Reference assembly

Range

19690033..19695260 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_168809.4 → NP_730442.2 vermiform, isoform G [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_730442.2

Status: REVIEWED

UniProtKB/TrEMBL

Q06RG9, Q8IQU1, Q9VW32

Conserved Domains (3) summary

cd10974
Location:183 → 458

CE4_CDA_like_1; Putative catalytic domain of chitin deacetylase-like proteins with additional chitin-binding peritrophin-A domain (ChBD) and/or a low-density lipoprotein receptor class A domain (LDLa)

cd00112
Location:108 → 142

LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...

pfam01607
Location:33 → 88

CBM_14; Chitin binding Peritrophin-A domain
NM_168808.4 → NP_730441.1 vermiform, isoform H [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_730441.1

Status: REVIEWED

UniProtKB/TrEMBL

Q06RG9, Q9VW31

Related

FBpp0311365

Conserved Domains (3) summary

cd10974
Location:189 → 464

CE4_CDA_like_1; Putative catalytic domain of chitin deacetylase-like proteins with additional chitin-binding peritrophin-A domain (ChBD) and/or a low-density lipoprotein receptor class A domain (LDLa)

cd00112
Location:114 → 148

LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...

pfam01607
Location:33 → 94

CBM_14; Chitin binding Peritrophin-A domain
NM_001169998.3 → NP_001163469.1 vermiform, isoform I [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001163469.1

Status: REVIEWED

UniProtKB/TrEMBL

E1JI40, F0JAQ2

Conserved Domains (3) summary

cd10974
Location:213 → 488

CE4_CDA_like_1; Putative catalytic domain of chitin deacetylase-like proteins with additional chitin-binding peritrophin-A domain (ChBD) and/or a low-density lipoprotein receptor class A domain (LDLa)

cd00112
Location:138 → 172

LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...

pfam01607
Location:57 → 118

CBM_14; Chitin binding Peritrophin-A domain