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    Fas1 Fasciclin 1 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 42025, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Fas1provided by FlyBase
    Official Full Name
    Fasciclin 1provided by FlyBase
    Primary source
    FLYBASE:FBgn0285925
    Locus tag
    Dmel_CG6588
    See related
    AllianceGenome:FB:FBgn0285925
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG6588; Dmel\CG6588; DROFAS; DROFAS1; DROFASI; fas I; Fas I; fas-I; fas1; fasI; FasI; FGM222E05; gasI; MRE24
    Summary
    Enables cell adhesion molecule binding activity. Involved in calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules; homophilic cell adhesion via plasma membrane adhesion molecules; and neuron development. Located in plasma membrane. Is expressed in several structures, including cuboidal/columnar epithelium; ganglia; larval CNS neuron; neuron projection bundle; and sense organ. [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
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    Genomic context

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    See Fas1 in Genome Data Viewer
    Location:
    89D5-89D6; 3-59 cM
    Exon count:
    18
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (16625238..16639771)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (12450960..12465493)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene Coiled-coil domain containing protein 114 Neighboring gene nonA-like Neighboring gene ADP-ribosylation factor-like 6 interacting protein 1 Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Alternative splicing of micro-exons creates multiple forms of the insect cell adhesion molecule fasciclin I. McAllister L, et al. J Neurosci, 1992 Mar. PMID 1545245, Free PMC Article
    2. Expression and structural studies of fasciclin I, an insect cell adhesion molecule. Wang WC, et al. J Biol Chem, 1993 Jan 15. PMID 8419345
    3. Altered nerve terminal arborization and synaptic transmission in Drosophila mutants of cell adhesion molecule fasciclin I. Zhong Y, et al. J Neurosci, 1995 Oct. PMID 7472428, Free PMC Article
    4. Derivation-dependent distribution of insertion sites for a Drosophila transposon. Ising G, et al. Cold Spring Harb Symp Quant Biol, 1981. PMID 6266746
    5. Drosophila fasciclin I, a neural cell adhesion molecule, has a phosphatidylinositol lipid membrane anchor that is developmentally regulated. Hortsch M, et al. J Biol Chem, 1990 Sep 5. PMID 2394715

    See all (130) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables cell adhesion molecule binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables cell adhesion molecule binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in axon guidance IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in cell adhesion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in extracellular matrix organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in homophilic cell adhesion via plasma membrane adhesion molecules IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in neuron recognition IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in extracellular matrix IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane HDA PubMed 
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    fasciclin 1
    Names
    CG6588-PA
    CG6588-PB
    CG6588-PC
    CG6588-PD
    CG6588-PE
    CG6588-PF
    CG6588-PG
    Fas1-PA
    Fas1-PB
    Fas1-PC
    Fas1-PD
    Fas1-PE
    Fas1-PF
    Fas1-PG
    Fasciclin-1
    fasciclin I
    mRNA-like ncRNA in embryogenesis 24

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      16625238..16639771
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001275716.1 → NP_001262645.1  fasciclin 1, isoform G [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001262645.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0B4KH94
      Conserved Domains (2) summary
      smart00554
      Location:355 → 463
      FAS1; Four repeated domains in the Fasciclin I family of proteins, present in many other contexts
      pfam02469
      Location:31 → 146
      Fasciclin; Fasciclin domain

    2. NM_001144594.2 → NP_001138066.1  fasciclin 1, isoform F [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001138066.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      B7Z0L0
      Conserved Domains (2) summary
      smart00554
      Location:355 → 463
      FAS1; Four repeated domains in the Fasciclin I family of proteins, present in many other contexts
      pfam02469
      Location:31 → 146
      Fasciclin; Fasciclin domain

    3. NM_001104344.2 → NP_001097814.1  fasciclin 1, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001097814.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A8JR25
      Conserved Domains (2) summary
      smart00554
      Location:368 → 476
      FAS1; Four repeated domains in the Fasciclin I family of proteins, present in many other contexts
      pfam02469
      Location:488 → 627
      Fasciclin; Fasciclin domain

    4. NM_169724.2 → NP_732164.1  fasciclin 1, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_732164.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8INA9
      Related
      FBpp0082784
      Conserved Domains (2) summary
      smart00554
      Location:361 → 469
      FAS1; Four repeated domains in the Fasciclin I family of proteins, present in many other contexts
      pfam02469
      Location:481 → 620
      Fasciclin; Fasciclin domain

    5. NM_001144593.2 → NP_001138065.1  fasciclin 1, isoform E [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001138065.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      B7Z0L1
      Conserved Domains (2) summary
      smart00554
      Location:355 → 463
      FAS1; Four repeated domains in the Fasciclin I family of proteins, present in many other contexts
      pfam02469
      Location:475 → 614
      Fasciclin; Fasciclin domain

    6. NM_169725.2 → NP_732165.1  fasciclin 1, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_732165.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P10674
      Related
      FBpp0082783
      Conserved Domains (2) summary
      smart00554
      Location:358 → 466
      FAS1; Four repeated domains in the Fasciclin I family of proteins, present in many other contexts
      pfam02469
      Location:478 → 617
      Fasciclin; Fasciclin domain

    7. NM_169726.2 → NP_732166.1  fasciclin 1, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_732166.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VES3
      Related
      FBpp0082782
      Conserved Domains (2) summary
      smart00554
      Location:355 → 463
      FAS1; Four repeated domains in the Fasciclin I family of proteins, present in many other contexts
      pfam02469
      Location:475 → 614
      Fasciclin; Fasciclin domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A0A0B4KH94 A0A0B4KH94
    A8JR25 A8JR25
    B7Z0L0 B7Z0L0
    B7Z0L1 B7Z0L1
    P10674.1 P10674
    Q8INA9 Q8INA9
    Q8MSW3 Q8MSW3
    Q9VES3 Q9VES3

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