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    CRAT Carnitine O-Acetyl-Transferase [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 40787, updated on 9-Dec-2024

    Summary

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    Official Symbol
    CRATprovided by FlyBase
    Official Full Name
    Carnitine O-Acetyl-Transferaseprovided by FlyBase
    Primary source
    FLYBASE:FBgn0037440
    Locus tag
    Dmel_CG1041
    See related
    AllianceGenome:FB:FBgn0037440
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG1041; CrAT; Dmel\CG1041
    Summary
    Predicted to enable carnitine O-acetyltransferase activity. Predicted to be involved in carnitine metabolic process, CoA-linked. Located in peroxisome. Is expressed in adult brain cell body rind; adult gnathal ganglion; adult head; adult heart; and spermatozoon. Human ortholog(s) of this gene implicated in neurodegeneration with brain iron accumulation. Orthologous to human CRAT (carnitine O-acetyltransferase). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See CRAT in Genome Data Viewer
    Location:
    83E4-83E5; 3-47.5 cM
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (6371026..6376044, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (2196748..2201662, complement)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene p21-activated kinase Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene ncRNA Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene Transcription factor IIFalpha

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Peroxisomes are required for lipid metabolism and muscle function in Drosophila melanogaster. Faust JE, et al. PLoS One, 2014. PMID 24945818, Free PMC Article
    2. L-Carnitine in Drosophila: A Review. Carillo MR, et al. Antioxidants (Basel), 2020 Dec 21. PMID 33371457, Free PMC Article
    3. Phosphatidic acid as a limiting host metabolite for the proliferation of the microsporidium Tubulinosema ratisbonensis in Drosophila flies. Franchet A, et al. Nat Microbiol, 2019 Apr. PMID 30692666
    4. Selective sweep analysis in the genomes of the 91-R and 91-C Drosophila melanogaster strains reveals few of the 'usual suspects' in dichlorodiphenyltrichloroethane (DDT) resistance. Steele LD, et al. PLoS One, 2015. PMID 25826265, Free PMC Article
    5. Wnt/Wingless signaling promotes lipid mobilization through signal-induced transcriptional repression. Liu M, et al. Proc Natl Acad Sci U S A, 2024 Jul 9. PMID 38968125, Free PMC Article

    See all (43) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables acyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables carnitine O-acetyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables carnitine O-acetyltransferase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in carnitine metabolic process, CoA-linked IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in carnitine metabolic process, CoA-linked ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in fatty acid beta-oxidation NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in fatty acid beta-oxidation using acyl-CoA oxidase ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    located_in mitochondrion ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in nucleoplasm HDA PubMed 
    is_active_in peroxisome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in peroxisome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in peroxisome ISM
    Inferred from Sequence Model
    more info
    		 PubMed 
    located_in peroxisome ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    carnitine O-Acetyl-Transferase
    Names
    CG1041-PA
    CG1041-PB
    CG1041-PD
    CG1041-PE
    CRAT-PA
    CRAT-PB
    CRAT-PD
    CRAT-PE
    carnitine O-acetyl-transferase
    carnitine acetyltransferase
    NP_001036684.1
    NP_001287195.1
    NP_001303419.1
    NP_649650.2

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      6371026..6376044 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001316490.1 → NP_001303419.1  carnitine O-Acetyl-Transferase, isoform E [Drosophila melanogaster]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A126GUQ4
      Conserved Domains (1) summary
      pfam00755
      Location:50 → 624
      Carn_acyltransf; Choline/Carnitine o-acyltransferase

    2. NM_141393.2 → NP_649650.2  carnitine O-Acetyl-Transferase, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_649650.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VI16
      Related
      FBpp0081231
      Conserved Domains (1) summary
      pfam00755
      Location:74 → 648
      Carn_acyltransf; Choline/Carnitine o-acyltransferase

    3. NM_001300266.1 → NP_001287195.1  carnitine O-Acetyl-Transferase, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001287195.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VI16
      Conserved Domains (1) summary
      pfam00755
      Location:74 → 648
      Carn_acyltransf; Choline/Carnitine o-acyltransferase

    4. NM_001043219.1 → NP_001036684.1  carnitine O-Acetyl-Transferase, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001036684.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      C9QP39, Q0KIA8
      Conserved Domains (1) summary
      pfam00755
      Location:69 → 643
      Carn_acyltransf; Choline/Carnitine o-acyltransferase
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A0A126GUQ4 A0A126GUQ4
    Q0KIA8 Q0KIA8
    Q9VI16 Q9VI16

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