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    FASN1 Fatty acid synthase 1 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 33524, updated on 17-Dec-2024

    Summary

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    Official Symbol
    FASN1provided by FlyBase
    Official Full Name
    Fatty acid synthase 1provided by FlyBase
    Primary source
    FLYBASE:FBgn0283427
    Locus tag
    Dmel_CG3523
    See related
    AllianceGenome:FB:FBgn0283427
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    anon-EST:Posey235; anon-EST:Posey43; anon-WO0138581.1; BcDNA:gh07626; BcDNA:GH07626; CG3523; dFAS; dFASN; dFASN1; Dmel\CG3523; DM_7295848; fas; Fas; FAS; FAS1; fasn; Fasn; FASN; Fasn1; FASN[CG3523]; FAS[CG3523]; Fatty acid synthase
    Summary
    Enables fatty acid synthase activity. Involved in cellular response to sucrose stimulus; intracellular triglyceride homeostasis; and triglyceride biosynthetic process. Acts upstream of with a positive effect on regulation of lipid storage. Is expressed in adult fat body; adult head; adult heart; and embryonic/larval fat body. Orthologous to human FASN (fatty acid synthase). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See FASN1 in Genome Data Viewer
    Location:
    23C5-23D1; 2-8 cM
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (3056598..3068177)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (3056598..3068177)

    Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene small nuclear RNA U5 at 23D Neighboring gene small nuclear RNA Like U Neighboring gene Fatty acid synthase 2 Neighboring gene toucan Neighboring gene Protein phosphatase D6 Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Jinggangmycin stimulates reproduction and increases CHCs-dependent desiccation tolerance in Drosophila melanogaster. Dong W, et al. Pestic Biochem Physiol, 2023 Aug. PMID 37532348
    2. Immuno-electron microscopy of primary cell cultures from genetically modified animals in liquid by atmospheric scanning electron microscopy. Kinoshita T, et al. Microsc Microanal, 2014 Apr. PMID 24564988
    3. The regulation of triglyceride and glycogen storage by Glucose transporter 1 ( Glut1 ) in Drosophila fat tissue. Betz LS, et al. MicroPubl Biol, 2024. PMID 38495587, Free PMC Article
    4. Cell-Autonomous Control of Neuronal Dendrite Expansion via the Fatty Acid Synthesis Regulator SREBP. Ziegler AB, et al. Cell Rep, 2017 Dec 19. PMID 29262315
    5. Elevated Levels of the Reactive Metabolite Methylglyoxal Recapitulate Progression of Type 2 Diabetes. Moraru A, et al. Cell Metab, 2018 Apr 3. PMID 29551588

    See all (186) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables 3-oxoacyl-[acyl-carrier-protein] synthase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables [acyl-carrier-protein] S-acetyltransferase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables fatty acid synthase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables fatty acid synthase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables oxidoreductase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables phosphopantetheine binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables serine hydrolase activity HDA PubMed 
    Process Evidence Code Pubs
    involved_in biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in cellular response to sucrose stimulus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in fatty acid biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in fatty acid biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in intracellular triglyceride homeostasis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in lipid biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_positive_effect regulation of lipid storage IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in response to sucrose IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in triglyceride biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytosol ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    fatty acid synthase 1
    Names
    CG3523-PA
    CG3523-PC
    FASN1-PA
    FASN1-PC
    fatty acid synthase
    fatty acid synthetase
    NP_001137778.2
    NP_608748.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033779.5 Reference assembly

      Range
      3056598..3068177
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_134904.3 → NP_608748.1  fatty acid synthase 1, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_608748.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VQL7, Q9Y129
      Related
      FBpp0077343
      Conserved Domains (11) summary
      cd05195
      Location:1493 → 1781
      enoyl_red; enoyl reductase of polyketide synthase
      cd08954
      Location:1799 → 2039
      KR_1_FAS_SDR_x; beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 1, complex (x) SDRs
      smart00823
      Location:2052 → 2104
      PKS_PP; Phosphopantetheine attachment site
      smart00829
      Location:1491 → 1781
      PKS_ER; Enoylreductase
      COG3321
      Location:35 → 1040
      PksD; Acyl transferase domain in polyketide synthase (PKS) enzymes [Secondary metabolites biosynthesis, transport and catabolism]
      cd00833
      Location:38 → 442
      PKS; polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or ...
      pfam16197
      Location:400 → 510
      KAsynt_C_assoc; Ketoacyl-synthetase C-terminal extension
      cl00509
      Location:888 → 1132
      hot_dog; The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated ...
      cl08282
      Location:531 → 848
      Acyl_transf_1; Acyl transferase domain
      cl21454
      Location:1256 → 1448
      NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins
      cl21494
      Location:2184 → 2433
      Abhydrolase; alpha/beta hydrolases

    2. NM_001144306.2 → NP_001137778.2  fatty acid synthase 1, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001137778.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      B7Z001
      Conserved Domains (11) summary
      cd05195
      Location:1595 → 1883
      enoyl_red; enoyl reductase of polyketide synthase
      cd08954
      Location:1901 → 2141
      KR_1_FAS_SDR_x; beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 1, complex (x) SDRs
      smart00823
      Location:2154 → 2206
      PKS_PP; Phosphopantetheine attachment site
      smart00829
      Location:1593 → 1883
      PKS_ER; Enoylreductase
      COG3321
      Location:137 → 1142
      PksD; Acyl transferase domain in polyketide synthase (PKS) enzymes [Secondary metabolites biosynthesis, transport and catabolism]
      cd00833
      Location:140 → 544
      PKS; polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or ...
      pfam16197
      Location:502 → 612
      KAsynt_C_assoc; Ketoacyl-synthetase C-terminal extension
      cl00509
      Location:990 → 1234
      hot_dog; The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated ...
      cl08282
      Location:633 → 950
      Acyl_transf_1; Acyl transferase domain
      cl21454
      Location:1358 → 1550
      NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins
      cl21494
      Location:2286 → 2535
      Abhydrolase; alpha/beta hydrolases
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    B7Z001 B7Z001
    Q7KML1 Q7KML1
    Q9VQL7 Q9VQL7

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