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    Ugt49C1 UDP-glycosyltransferase family 49 member C1 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 37421, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Ugt49C1provided by FlyBase
    Official Full Name
    UDP-glycosyltransferase family 49 member C1provided by FlyBase
    Primary source
    FLYBASE:FBgn0034605
    Locus tag
    Dmel_CG15661
    See related
    AllianceGenome:FB:FBgn0034605
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG15661; Dmel\CG15661; UGT49C1
    Summary
    Predicted to enable UDP-glycosyltransferase activity. Predicted to be involved in glycosylation. Predicted to be active in endoplasmic reticulum membrane. Is expressed in adult head. Orthologous to several human genes including UGT2B11 (UDP glucuronosyltransferase family 2 member B11) and UGT2B4 (UDP glucuronosyltransferase family 2 member B4). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Ugt49C1 in Genome Data Viewer
    Location:
    57D2-57D2; 2-94 cM
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (21215435..21217779, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (17102940..17105284, complement)

    Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene Glycogenin Neighboring gene UDP-glycosyltransferase family 49 member B1 Neighboring gene Ankyrin-repeat, SH3-domain, and Proline-rich-region containing Protein Neighboring gene Rad, Gem/Kir family member 3 Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Lamin Dysfunction Mediates Neurodegeneration in Tauopathies. Frost B, et al. Curr Biol, 2016 Jan 11. PMID 26725200, Free PMC Article
    2. Tau promotes neurodegeneration through global chromatin relaxation. Frost B, et al. Nat Neurosci, 2014 Mar. PMID 24464041, Free PMC Article
    3. The UDP-Glycosyltransferase Family in Drosophila melanogaster: Nomenclature Update, Gene Expression and Phylogenetic Analysis. Ahn SJ, et al. Front Physiol, 2021. PMID 33815151, Free PMC Article
    4. Functional and phylogenetic analyses of a putative Drosophila melanogaster UDP-glycosyltransferase gene. Luque T, et al. Insect Biochem Mol Biol, 2002 Dec. PMID 12429111
    5. Harnessing the paradoxical phenotypes of APOE ɛ2 and APOE ɛ4 to identify genetic modifiers in Alzheimer's disease. Kim YW, et al. Alzheimers Dement, 2021 May. PMID 33576571, Free PMC Article

    See all (29) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables UDP-glycosyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables UDP-glycosyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables UDP-glycosyltransferase activity ISM
    Inferred from Sequence Model
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in glycosylation ISM
    Inferred from Sequence Model
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in endoplasmic reticulum membrane ISM
    Inferred from Sequence Model
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    UDP-glycosyltransferase family 49 member C1
    Names
    CG15661-PA
    CG15661-PB
    Ugt49C1-PA
    Ugt49C1-PB

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033778.4 Reference assembly

      Range
      21215435..21217779 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_137720.4 → NP_611564.2  UDP-glycosyltransferase family 49 member C1, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_611564.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q4V5F2, Q4V5J6, Q4V5L6, Q9W2J3
      Conserved Domains (2) summary
      PHA03392
      Location:22 → 504
      egt; ecdysteroid UDP-glucosyltransferase; Provisional
      pfam00201
      Location:37 → 498
      UDPGT; UDP-glucoronosyl and UDP-glucosyl transferase

    2. NM_001043100.3 → NP_001036565.1  UDP-glycosyltransferase family 49 member C1, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001036565.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q4V5F2, Q4V5J6, Q4V5L6, Q9W2J3
      Conserved Domains (2) summary
      PHA03392
      Location:22 → 504
      egt; ecdysteroid UDP-glucosyltransferase; Provisional
      pfam00201
      Location:37 → 498
      UDPGT; UDP-glucoronosyl and UDP-glucosyl transferase
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9W2J3 Q9W2J3

    Gene LinkOut

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