Mlc1 Myosin alkali light chain 1 [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: Mlc1provided by FlyBase
Official Full Name: Myosin alkali light chain 1provided by FlyBase
Primary source: FLYBASE:FBgn0002772
Locus tag: Dmel_CG5596
See related: AllianceGenome:FB:FBgn0002772
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: CG5596; chr3R:23484557..23484663; Dmel\CG5596; DmMLC1; ELC; ELC2; ELC_3; LC1; mlc; MLC; Mlc-1; mlc-alk; MLC-ALK; mlc1; MLC1; Mlci; MlcI; mlcl; p-MLC
Summary: Predicted to enable calcium ion binding activity. Involved in mesoderm development. Located in cytosol. Part of muscle myosin complex. Is expressed in several structures, including adult heart; border follicle cell; embryonic/larval salivary gland; muscle cell; and organism subdivision. Human ortholog(s) of this gene implicated in hypertrophic cardiomyopathy 8. Orthologous to human MYL3 (myosin light chain 3) and MYL6B (myosin light chain 6B). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Genomic context

Location:: 98A14-98A15; 3-94 cM

Exon count:: 6

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	3R	NT_033777.3 (27657078..27660177, complement)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	3R	NT_033777.2 (23482800..23485899, complement)

Chromosome 3R - NT_033777.3 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
enables calcium ion binding	IEA Inferred from Electronic Annotation more info
enables enzyme regulator activity	NAS Non-traceable Author Statement more info	PubMed
enables myosin heavy chain binding	NAS Non-traceable Author Statement more info	PubMed

Process	Evidence Code	Pubs
involved_in mesoderm development	IEP Inferred from Expression Pattern more info	PubMed
involved_in muscle contraction	NAS Non-traceable Author Statement more info	PubMed
involved_in regulation of catalytic activity	NAS Non-traceable Author Statement more info	PubMed

Component	Evidence Code	Pubs
located_in cytosol	HDA more info	PubMed
part_of muscle myosin complex	IBA Inferred from Biological aspect of Ancestor more info
part_of muscle myosin complex	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: myosin alkali light chain 1

Names: CG5596-PA; CG5596-PB; CG5596-PD; Mlc1-PA; Mlc1-PB; Mlc1-PD; myosin; myosin 3R alkali light chain l; myosin alkali light chain l; myosin light Chain-1; myosin light chain; myosin light chain 1; myosin light chain alkali

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NT_033777.3 Reference assembly

Range

27657078..27660177 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001300640.1 → NP_001287569.1 myosin alkali light chain 1, isoform D [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001287569.1

Status: REVIEWED

UniProtKB/Swiss-Prot

P06742, P06743, P92155, P92156, P92157, P92183, P92187, P92196, Q24380, Q24381, Q24382, Q24383, Q27304, Q27315, Q27381, Q27414, Q94988, Q9VB12

UniProtKB/TrEMBL

A0A0B4LHS1, E6PBY9

Conserved Domains (2) summary

PTZ00184
Location:1 → 149

PTZ00184; calmodulin; Provisional

cl08302
Location:84 → 148

EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
NM_057291.4 → NP_476639.1 myosin alkali light chain 1, isoform A [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_476639.1

Status: REVIEWED

UniProtKB/TrEMBL

E6PBY9

Related

FBpp0084565

Conserved Domains (1) summary

COG5126
Location:26 → 152

FRQ1; Ca2+-binding protein, EF-hand superfamily [Signal transduction mechanisms]
NM_057292.4 → NP_476640.1 myosin alkali light chain 1, isoform B [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_476640.1

Status: REVIEWED

UniProtKB/Swiss-Prot

P06742, P06743, P92155, P92156, P92157, P92183, P92187, P92196, Q24380, Q24381, Q24382, Q24383, Q27304, Q27315, Q27381, Q27414, Q94988, Q9VB12

UniProtKB/TrEMBL

A0A0B4LHS1, E6PBY9

Related

FBpp0084566

Conserved Domains (2) summary

PTZ00184
Location:1 → 149

PTZ00184; calmodulin; Provisional

cl08302
Location:84 → 148

EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...