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    PH4alphaPV prolyl-4-hydroxylase-alpha PV [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 43640, updated on 9-Dec-2024

    Summary

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    Official Symbol
    PH4alphaPVprovided by FlyBase
    Official Full Name
    prolyl-4-hydroxylase-alpha PVprovided by FlyBase
    Primary source
    FLYBASE:FBgn0051015
    Locus tag
    Dmel_CG31015
    See related
    AllianceGenome:FB:FBgn0051015
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG31015; CG9713; Dmel\CG31015
    Summary
    Predicted to enable procollagen-proline 4-dioxygenase activity. Predicted to be active in endoplasmic reticulum. Is expressed in embryonic proventriculus and proventriculus primordium. [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See PH4alphaPV in Genome Data Viewer
    Location:
    100A1-100A1; 3-101 cM
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (30646106..30648551, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (26471828..26474273, complement)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene long non-coding RNA:CR46236 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Prolyl 4-hydroxylase alpha-related proteins in Drosophila melanogaster: tissue-specific embryonic expression of the 99F8-9 cluster. Abrams EW, et al. Mech Dev, 2002 Mar. PMID 11850189
    2. The progesterone antagonist mifepristone/RU486 blocks the negative effect on life span caused by mating in female Drosophila. Landis GN, et al. Aging (Albany NY), 2015 Jan. PMID 25614682, Free PMC Article
    3. Steroid Signaling Establishes a Female Metabolic State and Regulates SREBP to Control Oocyte Lipid Accumulation. Sieber MH, et al. Curr Biol, 2015 Apr 20. PMID 25802149, Free PMC Article
    4. Gene Expression Associated with Early and Late Chronotypes in Drosophila melanogaster. Pegoraro M, et al. Front Neurol, 2015. PMID 26097463, Free PMC Article
    5. mRNA-Associated Processes and Their Influence on Exon-Intron Structure in Drosophila melanogaster. Lepennetier G, et al. G3 (Bethesda), 2016 Jun 1. PMID 27172210, Free PMC Article

    See all (23) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables L-ascorbic acid binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables iron ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables procollagen-proline 4-dioxygenase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables procollagen-proline 4-dioxygenase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in endoplasmic reticulum IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in endoplasmic reticulum IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    prolyl-4-hydroxylase-alpha PV
    Names
    CG31015-PA
    PH4alphaPV-PA
    NP_733395.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      30646106..30648551 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_170516.1 → NP_733395.1  prolyl-4-hydroxylase-alpha PV [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_733395.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8T5S8
      Related
      FBpp0085032, FBtr0085670
      Conserved Domains (4) summary
      smart00702
      Location:339 → 510
      P4Hc; Prolyl 4-hydroxylase alpha subunit homologues
      sd00006
      Location:179 → 213
      TPR; TPR repeat [structural motif]
      pfam08336
      Location:35 → 164
      P4Ha_N; Prolyl 4-Hydroxylase alpha-subunit, N-terminal region
      pfam13414
      Location:179 → 250
      TPR_11; TPR repeat
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8MQN0 Q8MQN0
    Q8T5S8 Q8T5S8

    Gene LinkOut

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