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    TrpRS-m Tryptophanyl-tRNA synthetase, mitochondrial [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 39989, updated on 9-Dec-2024

    Summary

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    Official Symbol
    TrpRS-mprovided by FlyBase
    Official Full Name
    Tryptophanyl-tRNA synthetase, mitochondrialprovided by FlyBase
    Primary source
    FLYBASE:FBgn0036763
    Locus tag
    Dmel_CG7441
    See related
    AllianceGenome:FB:FBgn0036763
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    BEST:CK01295; CG7441; Dmel\CG7441; dmWARS2; GH31
    Summary
    Predicted to enable tryptophan-tRNA ligase activity. Predicted to be involved in mitochondrial tryptophanyl-tRNA aminoacylation. Predicted to be active in mitochondrial matrix. Is expressed in adult head. Orthologous to human WARS2 (tryptophanyl tRNA synthetase 2, mitochondrial). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See TrpRS-m in Genome Data Viewer
    Location:
    75A4-75A4; 3-45 cM
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (17849727..17852453)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (17842827..17845553)

    Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene Mediator complex subunit 19 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Mutations in the mitochondrial tryptophanyl-tRNA synthetase cause growth retardation and progressive leukoencephalopathy. Maffezzini C, et al. Mol Genet Genomic Med, 2019 Jun. PMID 30920170, Free PMC Article
    2. The aminoacyl-tRNA synthetases of Drosophila melanogaster. Lu J, et al. Fly (Austin), 2015. PMID 26761199, Free PMC Article
    3. Sex-specific expression of alternative transcripts in Drosophila. McIntyre LM, et al. Genome Biol, 2006. PMID 16934145, Free PMC Article
    4. Copper homeostasis gene discovery in Drosophila melanogaster. Norgate M, et al. Biometals, 2007 Jun. PMID 17216353
    5. Rapidly evolving genes of Drosophila: differing levels of selective pressure in testis, ovary, and head tissues between sibling species. Jagadeeshan S, et al. Mol Biol Evol, 2005 Sep. PMID 15917496

    See all (34) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables tryptophan-tRNA ligase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables tryptophan-tRNA ligase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables tryptophan-tRNA ligase activity TAS
    Traceable Author Statement
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in mitochondrial tryptophanyl-tRNA aminoacylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in mitochondrial tryptophanyl-tRNA aminoacylation ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in tryptophanyl-tRNA aminoacylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in tryptophanyl-tRNA aminoacylation TAS
    Traceable Author Statement
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in mitochondrial matrix IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in mitochondrion ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in mitochondrion TAS
    Traceable Author Statement
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    Tryptophanyl-tRNA synthetase, mitochondrial
    Names
    CG7441-PA
    CG7441-PB
    TrpRS-m-PA
    TrpRS-m-PB
    NP_001262001.1
    NP_649018.2

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_037436.4 Reference assembly

      Range
      17849727..17852453
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_140761.3 → NP_649018.2  Tryptophanyl-tRNA synthetase, mitochondrial, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_649018.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VVL8
      Related
      FBpp0074907
      Conserved Domains (2) summary
      cd00806
      Location:82 → 359
      TrpRS_core; catalytic core domain of tryptophanyl-tRNA synthetase
      PRK00927
      Location:82 → 406
      PRK00927; tryptophanyl-tRNA synthetase; Reviewed

    2. NM_001275072.1 → NP_001262001.1  Tryptophanyl-tRNA synthetase, mitochondrial, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001262001.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VVL8
      Conserved Domains (2) summary
      cd00806
      Location:82 → 359
      TrpRS_core; catalytic core domain of tryptophanyl-tRNA synthetase
      PRK00927
      Location:82 → 406
      PRK00927; tryptophanyl-tRNA synthetase; Reviewed
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8SZU2 Q8SZU2
    Q9VVL8 Q9VVL8

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